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Michael Julien Alexandre Girard

Associate Professor

Principal Investigator, Head of the Ophthalmic Engineering & Innovation Laboratory (OEIL)

Co-Head of the Bioengineering & Devices Research Group, Singapore Eye Research Institute

Email

Education Qualifications: MSc, PhD

Dr Girard is currently an Associate Professor at the Duke-NUS Medical School, and Principal Investigator I at the Singapore Eye Research Institute (SERI) where he heads the Ophthalmic Engineering & Innovation Laboratory (OEIL), and co-heads the Bioengineering & Devices Research Group. Dr Girard has strong expertise in Ophthalmic Engineering with a focus on Artificial Intelligence, Biomedical Imaging, Ocular Biomechanics, and Ophthalmic Devices. His research has especially focused on optic neuropathies (including glaucoma), but also myopia, corneal disorders, and cataract. Dr Girard’s research has remained translational, and he is the founder of the Singapore start-up company Abyss Processing Pte Ltd, that provides 3D AI solutions to simplify and improve glaucoma diagnosis & prognosis. Dr Girard has authored 120+ papers in top Ophthalmology and Engineering journals, has given 50+ invited talks, has received 30+ research grants & 20+ research awards. As a PI, he has received more than $5.8M in research funding, and he has licensed 5 technologies to local and international MedTech companies. 

Professional Appointments and Committee Memberships:

  • Associate Advisory Board Member, World Glaucoma Association (2017 – Present)
  • Member, Communication & Technology Committee, World Glaucoma Association (2021 – Present)
  • Editorial Board Member, Modeling and Artificial Intelligence in Ophthalmology (MAIO) – Publisher: Kugler Publications
  • Editorial Board Member, Translational Vision Science & Technology (TVT) – Publisher: ARVO
  • Member, Association for Research in Vision and Ophthalmology (ARVO) (2013-Present)

Awards:

  • 8 Travel Grant Award from the Ophthalmic Engineering & Innovation Laboratory (OEIL), ARVO (2012-2019)
  • Young Investigator Award - Competitive & Prestigious NUS Award, NUS (2014)
  • National Glaucoma Award, BrightFocus (2012)
  • X’treme Research Award, Heidelberg Engineering (2012)
  • Travel Fellowship, ISER (2010)
  • Imperial College Junior Research Fellowship (2010)
  • Young Investigator Award, Casey Eye Research Institute (2007)

Leadership positions / roles in Education: 

  • Head, Ophthalmic Engineering & Innovation Laboratory (OEIL), SERI
  • Co-Head, Bioengineering & Devices Research Group, SERI

Research Interests:

  • Ophthalmic Engineering 
  • Deep Learning & Artificial Intelligence
  • Ocular Biomechanics 
  • Biomedical Imaging 
  • Ophthalmic Devices
  • Optic Neuropathies (including glaucoma), Myopia, Corneal Disorders, and Cataract

Selected Publications:

1. Cheong H, Devalla SK, Chuangsuwanich T, Tun TA, Wang X, Aung T, Schmetterer L, Buist ML, Boote C, Thiery A, Girard MJA. OCT-GAN: Single Step Shadow and Noise Removal from Optical Coherence Tomography Images of the Human Optic Nerve Head. 2021. Biomedical Optics Express. In Press. 

2. Panda SK, Cheong H, Tun TA, Devalla SK, Krishnadas R, Buist ML, Perera S, Cheng CY, Aung T, Thiery A, Girard MJA. Describing the Structural Phenotype of the Glaucomatous Optic Nerve Head Using Artificial Intelligence. 2020. arXiv:2012.09755. 

3. Girard MJA, Schmetterer L. Artificial Intelligence and Deep Learning: Current State and Future Prospect. In: Bagetta G, Nucci C. Glaucoma: A Neurodegenerative Disease of the Retina and Beyond. Progress in Brain Research. Volume 257, 27-64, Elsevier; 2020. 
4. Devalla SK, Pham TH, Panda SK, Zhang L, Subramanian G, Swaminathan A, Chin ZY, Rajan M, Mohan S, Krishnadas R, Senthil V, De Leon JM, Tun TA, Cheng CY, Schmetterer L, Perera S, Aung A, Thiery AH, Girard MJA. Towards Label-Free 3D Segmentation of Optical Coherence Tomography Images of the Optic Nerve Head Using Deep Learning. Biomedical Optic Express. 2020 Oct 15;11(11):6356-6378.

5. Boote C, Sigal IA, Grytz R, Hua H, Nguyen TD, Girard MJA. Scleral Structure and Biomechanics. 2020. Progress in Retinal and Eye Research 74, 100773.

6. Chuangsuwanich T, Pham TH, Leo HW, Boote C, Girard MJA. Morphometric, Hemodynamic, and Biomechanical Factors Influencing Blood Flow and Oxygen Concentration in the Human Lamina Cribrosa. IOVS. 61(4):3. 

7. Zhang L, Beotra MR, Baskaran M, Aung T, Goh JCH, Strouthidis NG, Girard MJA. In Vivo Measurements of Prelamina and Lamina Cribrosa Biomechanical Properties in Humans. 2020. IOVS. 61(3):27.  

8. Tan RKY, Tun TA, Boote C, Perera S, Girard MJA. Performance of a Temperature-controlled Shape-memory Pupil Expander for Cataract Surgery. 2020. Journal of Cataract & Refractive Surgery 46 (1), 116-124.  

9. Devalla S, Subramanian G, Pham TH, Schmetterer L, Aung T, Thiery A, Girard MJA. A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head. 2019. Scientific reports 9 (1), 1-13. 

10. Devalla SK, Renukanand PK, Sreedhar BK, Perera SA, Mari JM, Chin KS, Tun TA, Strouthidis N, Aung T, Thiery A, Girard MJA. DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images. Biomed Opt Express. 2018 Jun 25;9(7):3244-3265.

11. Jin Y, Wang X, Zhang L, Jonas JB, Aung T, Schmetterer L, Girard MJA. Modeling the Origin of the Ocular Pulse and its Impact on the Optic Nerve Head. Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):3997-4010.

12. Tun TA, Atalay E, Baskaran M, Nongpiur ME, Htoon HM, Goh D, Cheng CY, Perera SA, Aung T, Strouthidis NG, Girard MJA. Association of Functional Loss with the Biomechanical Response of the Optic Nerve Head to Acute Intraocular Pressure Elevations. 2018. JAMA Ophthalmology. 36(2):184-192. 

13. Wang X, Fisher LK, Milea D, Jonas JB, Girard MJA. Predictions of Optic Nerve Traction Forces and Peripapillary Tissue Stresses Following Horizontal Eye Movements. 2017. Invest Ophthalmol Vis Sci. 2017, Vol.58, 2044-2053. doi:10.1167/iovs.16-21319.

14. Wang X, Beotra MR, Tun TA, Baskaran M, Perera SA, Aung T, Strouthidis NG, Milea D, Girard MJA. In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements. 2016. Invest Ophthalmol Vis Sci. October 2016, Vol.57, 5825-5833. doi:10.1167/iovs.16-20560. 

15. Wang X, Rumpel H, Lim WEH, Baskaran M, Perera SA, Nongpiur ME, Aung T, Milea D, Girard MJA. Finite Element Analysis Predicts Large Optic Nerve Head Strains During Horizontal Eye Movements. 2016. Invest Ophthalmol Vis Sci. Vol.57, 2452-2462. doi:10.1167/iovs.15-18986. 

16. Girard MJA, Beotra MR, Chin KS, Sandhu A, Clemo M, Nikita E, Kamal DS, Papadopoulos M, Mari JM, Aung T, Strouthidis NG. In vivo 3D Strain Mapping of the Optic Nerve Head Following IOP Lowering by Trabeculectomy. 2016. Ophthalmology. Vol. 123, Issue 6, Pages 1190–1200. 

17. Zhang L, Albon J, Jones H, Gouget CLM, Ethier CR, Goh JCH, Girard MJA. Collagen Microstructural Factors Influencing Optic Nerve Head Biomechanics. Invest Ophthalmol Vis Sci. 2015 Mar 3;56(3):2031-42. doi: 10.1167/iovs.14-15734.

18. Girard MJA, Dupps WJ, Mani B, Scarcelli G, Yun SH, Quigley HA, Sigal IA, Strouthidis NG. Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects. Curr Eye Res. 2015 Jan;40(1):1-18. doi: 10.3109/02713683.2014.914543. 

19. Girard MJA, Strouthidis NG, Ethier CR, Mari JM. Shadow Removal and Contrast Enhancement in Optical Coherence Tomography Images of the Human Optic Nerve Head. Invest Opthalmol and Vis Sci. 2011; 52(10):7738-48.

20. Girard MJA, Suh J-KF, Bottlang M, Burgoyne CF, Downs JC. Biomechanical Changes in the Sclera of Monkey Eyes Exposed to Chronic IOP Elevations. Invest Ophthalmol and Vis Sci. 2011; 52(8):5656-5669.