Education Qualifications: MBBS, MRCP (UK), FAMS (Med Onco), PhD (NUS)/NGS
Dr. Iain Tan is a Senior Consultant Medical Oncologist, leading the colorectal cancer service in Division of Medical Oncology, National Cancer Centre Singapore. He is the director of research for the division of Medical Oncology and the director of the NCCS-Satellite Tissue Repository. He is a clinician scientist (twice NMRC CSA awardee) and assistant professor at Duke-NUS and faculty member and principal investigator of the laboratory of applied cancer genomics in the Precision Medicine And Population Genomics program at Genome Institute of Singapore, A-Star and adjunct faculty at Cancer & Stem Cell Biology Program at Duke-NUS. He has published widely with over 80 publications (h-index 36) including first or senior/corresponding author publications in Journal of Clinical Oncology, Nature Genetics, Nature Medicine, Nature, JAMA. He has obtained numerous individual competitive grants (CS-IRG, CSA, IAF-ICP), is the corresponding principal investigator of a national collaborative grant on cancer liquid biopsies (IAF-PP, Calibre, $15 million) and is the co-investigator, theme or platform PI of other national collaborative projects (LCGs & IAF-PPs). He mentors multiple junior clinician scientists (mentor for 2 NMRC transition awardees) post-docs, PhD students including clinician scientist PhD students. His research focuses on the immuno-biology of colorectal cancer and non-invasive diagnostics. He is a member of the resident advisory committee and the chairman of the exit examinations for Medical Oncology. For his research, he has received the ASCO Young Investigator Award (2010) and ASCO Merit Award (2011). For his research and clinical service, he received the National Youth Award (2014), the country’s highest award for youths.
Professional Appointments and Committee Memberships:
- Research Director of Division of Medical Oncology, National Cancer Centre Singapore (2020-current)
- Director of NCCS Satellite STR Biobank, National Cancer Centre Singapore (2020-current)
- Senior Clinician Scientist, GIS Fellow, Genome Institute of Singapore (2013-current)
- Chairman, Exit Exam Committee (Medical Oncology)
- Member, Residency Advisory Committee (Medical Oncology)
- Program Lead, Luminal Gastrointestinal Cancer Comprehensive Research Program & Precision Diagnostics program, National Cancer Centre Singapore (2014-current)
- Chair, GI & Peritoneum Clinic, NCC new building committee workgroup, National Cancer Centre Singapore (2015-current)
- Member, Singapore Society of Oncology (2007-current)
- Member, American Society of Clinical Oncology (2008-current)
- Member, American Association of Clinical Research (2008-current)
- Member, European Society of Medical Oncology (2008-current)
- Council Member, College of Clinician Scientist Singapore (2014-current)
- Member, Pan-Asian Colorectal Cancer Guideline Committee (2013-current)
Awards:
- NMRC Clinician Scientist Award, 2018
- SingHealth Publish! Award (Outstanding), 2016
- NMRC Clinician Scientist Award, 2015
- Singapore Youth Award, 2014
- SingHealth Excellence Award: Distinguished Young Researcher Award, 2013
- SingHealth Publish! Award (Outstanding), 2012
- SingHealth Quality Award (Silver), 2011
- ASCO Merit Award (American Society of Clinical Oncology), 2011
- AACR-BMS Scholar in Training Award, 2010
- American Society of Clinical Oncology Young Investigator Award, 2010
- NRF-MOH Healthcare Research Scholarship, 2010
Leadership positions / roles in Education:
- Chair, Clinical Competency Committee, SingHealth Senior Residency Program in Medical Oncology (2013-2016)
- Chair, JCST Exit Exam Committee (2015-current)
Selected Publications:
1. Tan IB, Tan C, Hsu LY, Dan YY, Aw A, Cook AR, Lee VJ. Prevalence and Outcomes of SARS-CoV-2 Infection Among Migrant Workers in Singapore. JAMA. 2021 Feb 9;325(6):584-585.
2. Simoni Yannick; Becht Etienne; Fehlings Michael; Loh Chiew Yee; Koo Si-Lin; Teng Karen Wei Weng; Yeong Joe Poh Sheng; Nahar Rahul; Zhang Tong; Kared Hassen; Duan Kaibo; Ang Nicholas; Poidinger Michael; Lee Yin Yeng; Larbi Anis; Khng Alexis J; Tan Emile; Fu Cherylin; Mathew Ronnie; Teo Melissa; Lim Wan Teck; Toh Chee Keong; Ong Boon-Hean; Koh Tina; Hillmer Axel M; Takano Angela; Lim Tony Kiat Hon; Tan Eng Huat; Zhai Weiwei; Tan Daniel S W;Tan Iain Beehuat; Newell Evan W Bystander CD8 T cells are abundant and phenotypically distinct in human tumour infiltrates. Nature 2018; 557(7706):575-579
3. Li Huipeng; Courtois Elise T; Sengupta Debarka; Tan Yuliana; Chen Kok Hao; Goh Jolene Jie Lin; Kong Say Li; Chua Clarinda; Hon Lim Kiat; Tan Wah Siew; Wong Mark; Choi Paul Jongjoon; Wee Lawrence J K; Hillmer Axel M;Tan Iain Beehuat*; Robson Paul*; Prabhakar Shyam* Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nature genetics 2017; 49(5):708-718 *(co-corresponding)
4. Fukawa Tomoya; Yan-Jiang Benjamin Chua; Min-Wen Jason Chua; Jun-Hao Elwin Tan; Huang Dan; Qian Chao-Nan; Ong Pauline; Li Zhimei; Chen Shuwen; Mak Shi Ya; Lim Wan Jun; Kanayama Hiro-Omi; Mohan Rosmin Elsa; Wang Ruiqi Rachel; Lai Jiunn Herng; Chua Clarinda; Ong Hock Soo; Tan Ker-Kan; Ho Ying Swan;Tan Iain Beehuat*; Teh Bin Tean*; Shyh-Chang Ng*. Xcessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nature medicine 2016; 22(6):666-71
5. Tan Iain Beehuat; Ivanova Tatiana; Lim Kiat Hon; Ong Chee Wee; Deng Niantao; Lee Julian; Tan Sze Huey; Wu Jeanie; Lee Ming Hui; Ooi Chia Huey; Rha Sun Young; Wong Wai Keong; Boussioutas Alex; Yeoh Khay Guan; So Jimmy; Yong Wei Peng; Tsuburaya Akira; Grabsch Heike; Toh Han Chong; Rozen Steven; Cheong Jae Ho; Noh Sung Hoon; Wan Wei Kiat; Ajani Jaffer A; Lee Ju-Seog; Tellez Manuel Salto; Tan Patrick Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology 2011; 141(2):476-85,
6. Tan Iain Beehuat; Cutcutache Ioana; Zang Zhi Jiang; Iqbal Jabed; Yap Seow Fong; Hwang William; Lim Wan-Teck; Teh Bin Tean; Rozen Steve; Tan Eng-Huat; Tan Patrick Fanconi's anemia in adulthood: chemoradiation-induced bone marrow failure and a novel FANCA mutation identified by targeted deep sequencing. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011; 29(20):591-4
7. Suzuki Yuka; Ng Sarah Boonhsi; Chua Clarinda; Leow Wei Qiang; Chng Jermain; Liu Shi Yang; Ramnarayanan Kalpana; Gan Anna; Ho Dan Liang; Ten Rachel; Su Yan; Lezhava Alexandar; Lai Jiunn Herng; Koh Dennis; Lim Kiat Hon; Tan Patrick; Rozen Steven G; Tan Iain Beehuat. Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer. Molecular oncology 2017; 11(2):124-139
8. Ng SB, Chua C, Ng M, Gan A, Poon PS, Teo M, Fu C, Leow WQ, Lim KH, Chung A, Koo SL, Choo SP, Ho D, Rozen S, Tan P, Wong M, Burkholder WF, Tan IB. Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery. Sci Rep. 2017; 7
9. Guanhua Zhu, Yu A. Guo, Danliang Ho, Polly Poon, Zhong Wee Poh, Pui Mun Wong, Anna Gan, Mei Mei Chang, Dimitrios Kleftogiannis, Yi Ting Lau, Brenda Tay, Wan Jun Lim, Clarinda Chua, Tira J. Tan,
Si-Lin Koo, Dawn Q. Chong, Yoon Sim Yap, Iain Tan*, Sarah Ng*, Anders J. Skanderup*. Tissue -specific cell-free DNA degradation quantifies circulating tumor DNA burden. Nature Comms. 2021 * co-corresponding
10. Tan R Y C; Camat M D; Ng M; Lim T H; Lim A S T; Lim K H;Tan I B H. HER2 positive rates are enriched amongst colorectal cancer brain metastases: a study amongst 1920 consecutive patients. Annals of oncology 29(7):1598-1599