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Anderson Danielle Elizabeth

Assistant Professor

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Dr Danielle Anderson is the Scientific Director of the Duke-NUS Medical School ABSL3 laboratory. In January 2020, Asst Prof Anderson and her team isolated SARS-CoV-2 from a clinical sample from one of the first COVID-19 patients in Singapore. From this, she helped to develop a test kit for COVID-19, which has vitally assisted the Singapore authorities with its contact tracing efforts.

Dr Anderson’s research interests include understanding the virus/host relationship of a diverse group of medically important negative-stranded RNA viruses that includes Measles virus, Mumps virus and Nipah virus. These paramyxoviruses are not only responsible for a high degree of morbidity and mortality worldwide but also cause encephalitis.  In addition, Dr Anderson utilises novel diagnostic platforms for the identification of not only new paramyxoviruses, but also other clinically relevant emerging infectious diseases, such as MERS and Zika virus.

Acute onset of bilateral follicular conjunctivitis in 2 patients with confirmed SARS-CoV-2 infections. Louis W Lim, Glorijoy S Tan, Vernon Yong, Danielle E Anderson, David C. Lye, Barnaby Young and Rupesh Agrawal. Ocular Immunology and Inflammation. In Press. 2020.

Viral dynamics and immune correlates of COVID-19 disease severity. Barnaby E Young, Sean WX Ong, Lisa FP Ng, Danielle E Anderson, Wan Ni Chia, Po Ying Chia, Li Wei Ang, Shirin Kalimuddin, Louis Chai, Surinder Pada, Seow Yen Tan, Louisa Sun, Purnima Parthasarathy, Siew Wai Fong, Yi Hao Chan, Chee Wah Tan, Bernett Lee, Olaf Rötzschke, Paul Tambyah, Jenny GH Low, Cui Lin, Timothy Barkham, Raymond Tzer Pin Lin, Yee-Sin Leo, Laurent Renia, Lin-Fa Wang, David Chien Lye on behalf of Singapore 2019 Novel Coronavirus Outbreak Research team. Clinical Infectious Diseases. In Press. 2020. 

Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study. Barnaby E Young, Siew-Wai Fong, Yi-Hao Chan PhD, Tze-Minn Mak, Li Wei Ang, Danielle E Anderson, Cheryl Yi-Pin Lee, Siti Naqiah Amrun, Bernett Lee, Yun Shan Goh, Yvonne C F Su, Wycliffe E Wei, Shirin Kalimuddin, Louis Yi Ann Chai, Surinder Pada, Seow Yen Tan, Louisa Sun, Purnima Parthasarathy, Yuan Yi Constance Chen, Timothy Barkham, Raymond Tzer Pin Lin, Sebastian Maurer-Stroh, Yee-Sin Leo, Lin-Fa Wang, Laurent Renia, Vernon J Lee, Gavin JD Smith, David Chien Lye and Lisa FP Ng. Lancet. Aug 18. doi: https://doi.org/10.1016/S0140-6736(20)31757-8. 2020.PMID: 32822564 

A SARS-CoV-2 surrogate virus neutralization test (sVNT) 1 based on antibody-mediated blockage of ACE2-spike (RBD) protein-protein interaction. Chee Wah Tan, Wan Ni Chia, Xijian Qin, Pei Liu, Mark I-C Chen, Charles Tiu, Zhiliang Hu, Vivian Chih-Wei Chen, Barnaby E Young, Wan Rong Sia, Yee-Joo Tan, Randy Foo, Yongxiang Yi, David C. Lye, Danielle E. Anderson*, Lin-Fa Wang* (*Corresponding authors). Nature Biotechnology. Jul 23. doi: 10.1038/s41587-020-0631-z. 2020. PMID: 32704169 

Discovery of a 382-nt deletion during the early evolution of SARS-CoV-2. Yvonne CF Su*, Danielle E Anderson*, Barnaby E Young, Feng Zhu, Martin Linster, Shirin Kalimuddin, Jenny GH Low, Yan Zhuang, Jayanthi Jayakumar, Chee Wah Tan, Wan Ni Chia, Tze Minn Mak, Sophie Octavia, Jean-Marc Chavatte, Surinder Pada, Seow Yen Tan, Louisa Sun, Gabriel Z Yan, Ian H Mendenhall, Yee-Sin Leo, David Chien Lye, Lin-Fa Wang and Gavin JD Smith. (*Authors contributed equally). MBio. Jul 21;11(4):e01610-20. 2020. PMID: 32694143 

Povidone-Iodine demonstrates rapid in vitro virucidal activity against SARS-CoV-2, the virus causing COVID-19 disease. Danielle E Anderson*^, Velraj Sivalingam, Adrian Eng Zheng Kang, Abhishek Ananthanarayanan, Harsha Arumugam, Timothy M Jenkins, Yacine Hadjiat and Maren Eggers^ (*Authors contributed equally, ^corresponding authors). Infectious Diseases and Therapy. Jul 8; 9(3), 669-675. 2020. PMID: 32643111 

Utilising animal models to evaluate oseltamivir efficacy against influenza A and B viruses with reduced in vitro susceptibility. Rubaiyea Farrukee, Celeste Ming-Kay Tai, Ding Yuan Oh, Danielle E Anderson, Vithiagaran Gunalan, Martin Hibberd, Gary Yuk-Fai Lau, Ian G Barr, Veronika von Messling, Sebastian Maurer-Stroh and Aeron C Hurt. PloS Pathogens. Jun 18;16(6):e1008592. 2020. PMID: 32555740 

Wan Ni Chia, Chee Wah Tan, Randy Foo, Eng Zheng Kang, Yilong Peng, Velraj Sivalingam, Charles Tiu, Feng Zhu, Barnaby E. Young, Mark I-C Chen, Yee-Joo Tan, David C Lye, Danielle E Anderson^, Lin-Fa Wang^ (^corresponding authors). Serological differentiation between COVID-19 and SARS infections. Emerging Microbes & Infections. Jun 12;1-23. 2020. PMID: 32529906 

Adrian C Paskey, Justin HJ Ng, Gregory K Rice, Wan Ni Chia, Casandra W Philipson, Randy JH Foo, Regina Z Cer, Kyle A Long, Matthew R Lueder, Xiao Fang Lim, Kenneth G Frey, Theron Hamilton, Danielle E Anderson, Eric D Laing, Ian H Mendenhall, Gavin J Smith, Lin-Fa Wang, Kimberly A Bishop-Lilly. Detection of Recombinant Rousettus Bat Coronavirus GCCDC1 in Lesser Dawn Bats (Eonycteris spelaea) in Singapore. Viruses. May 14;12(5):E539, 2020. PMID: 32422932 

Danielle E Anderson*^, Chee Wah Tan*, Wan Ni Chia*, Barnaby E Young, Martin Linster, Jenny G H Low, Yee-Joo Tan, Mark I-C Chen, Gavin JD Smith, Yee Sin Leo, David C Lye and Lin-Fa Wang^. (*Authors contributed equally, ^corresponding authors). Lack of cross neutralization by SARS patient sera towards SARS-CoV-2. Emerging Microbes & Infections, Dec;9(1):900-902. 2020. PMID: 32380903 

Sarah Ee Fang Yong*, Danielle E Anderson*, Wycliffe E Wei, Junxiong Pang, Wan Ni Chia, Chee Wah Tan, Yee Leong Teoh,Priyanka Rajendram, Matthias Paul Han Sim Toh, Cuiqin Poh, Valerie TJ Koh, Joshua Lum, Nur-Afidah Md Suhaimi, Po Ying Chia, Mark I-Cheng Chen, Shawn Vasoo, Benjamin Ong, Yee Sin Leo, Lin-Fa Wang, Vernon J M Lee (*Authors contributed equally). Connecting clusters of COVID-19 through epidemiological and serological investigations: an outbreak investigation. Lancet Infectious Diseases. Apr 21;S1473-3099(20)30273-5. 2020. PMID: 32330439 

Ivan Seah Yu Jun, Danielle E Anderson, Adrian Eng Zheng Kang, Lin-Fa Wang, Pooja Rao, Barnaby E Young, David C Lye, Rupesh Agrawal. Assessing Viral Shedding and Infectivity of Tears in COVID-19 Patients. Ophthalmology. Mar 24;S0161-6420(20)30311-0. 2020. PMID: 32291098 

Barnaby E Young, Sean Wei Xiang Ong, Shirin Kalimuddin, Jenny G Low, Seow Yen Tan, Jiashen Loh, Oon-Tek Ng, Kalisvar Marimuthu, Li Wei Ang, Tze Minn Mak, Sok Kiang Lau, Danielle E Anderson, Kian Sing Chan, Thean Yen Tan, Tong Yong Ng, Lin Cui, Zubaidah Said, Lalitha Kurupatham, Mark I-Cheng Chen, Monica Chan, Shawn Vasoo, Lin-Fa Wang, Boon Huan Tan, Raymond Tzer Pin Lin, Vernon Jian Ming Lee, Yee-Sin Leo, David C Lye, Singapore 2019 Novel Coronavirus Outbreak Research Team. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. Journal of the American Medical Association. Mar 3;323(15):1488-1494. 2020. PMID: 32125362 

Lin-Fa Wang, Danielle E Anderson, John S Mackenzie, Michael H Merson. From Hendra to Wuhan: What has been learned in responding to emerging zoonotic viruses. Lancet. Feb 22;395(10224):e33-e34. 2020. PMID: 32059799 

Peng Zhou, Bei Li, Hao-Rui Si, Yan Zhu, Xing-Lou Yang, Danielle E Anderson, Zheng-Li Shi, Lin-Fa Wang. Discovery of bat coronaviruses through surveillance and probe capture-based next generation sequencing. mSphere. Jan 29;5(1):e00807-19. 2020. PMID: 31996413 

Wei Zhang, Xiao-Shuang Zheng, Bernard Agwanda, Sheila Ommeh, Kai Zhao, Jacqueline Lichoti, Ning Wang, Jing Chen, Bei Li, Xing-Lou Yang, Shailendra Mani, Kisa-Juma Ngeiywa, Yan Zhu, Ben Hu, Samson Omondi Onyuok, Bing Yan, Danielle E Anderson, Lin-Fa Wang, Peng Zhou, Zheng-Li Shi. Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels. Emerging Microbes & Infections. 8(1):1528-1534. 2019. PMID: 31645223 

Nagendrakumar B Singanallura, Danielle E Anderson, October M Sessions, Uma S Kamaraj, Timothy R Bowden, Jacquelyn Horsington, Christopher Cowled, Lin-Fa Wang, Wilna Vosloo. Probe capture enrichment next generation sequencing of complete foot-and-mouth disease virus genomes in clinical samples. Journal of Virological Methods. Oct;272:113703, 2019. PMID: 31336142 

Xiao Fang Lim, Chengfa Benjamin Lee, Sarah Marie Pascoe, Choon Beng How, Sharon Chan, Jun Hao Tan, Xinglou Yang, Peng Zhou, Zhengli Shi, October M. Sessions, Lin-Fa Wang, Lee Ching Ng, Danielle E Anderson^, Grace Yap^ (^Corresponding authors). Detection and characterization of a novel bat-borne coronavirus in Singapore using multiple molecular approaches. Journal of General Virology. Oct;100(10):1363-1374, 2019. PMID: 31418677 

Chee Wah Tan, Kevin Wittwer, Xiao Fang Lim, Anna Uehara, Shailendra Mani, Lin-Fa Wang and Danielle E Anderson. Serological evidence and experimental infection of cynomolgus macaques with pteropine orthoreovirus reveal monkeys as potential hosts for transmission to humans. Emerging Microbes & Infections. 8(1):787-795, 2019. PMID: 31132935 

Theresa Enkirch, Svenja Sauber, Danielle E Anderson, Esther S Gan, Dimitar Kenanov, Sebastian Maurer-Stroh, Veronika von Messling. Identification and In Vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs with Broad Anti-Influenza A Activity. Frontiers in Immunology. Jun 5;10:1097, 2019. PMID: 31244822 

Danielle E Anderson*, Kristin Pfeffermann*, So Young Kim, Bevan Sawatsky, James Pearson, Mikhail Kovtun, David L Corcoran, Yvonne Krebs, Kristmundur Sigmundsson, Sharon F Jamison, Zhen Zhen Joanna Yeo, Linda J Rennick, Lin-Fa Wang, Pierre J Talbot, W Paul Duprex, Mariano A Garcia-Blanco, Veronika von Messling (*Authors contributed equally). Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae. mBio. May 14;10(3):e00826-19, 2019. PMID: 31088929 

Uma Sangumathi Kamaraj, Jun Hao Tan, Ong Xin Mei, Louise Pan, Tanu Chawla, Anna Uehara, Lin-Fa Wang, Eng Eong Ooi, Duane J Gubler, Hasitha Tissera, Lee Ching Ng, Annelies Wilder-Smith, Paola Florez de Sessions, Timothy Barkham, Danielle E Anderson, October M Sessions. Application of a targeted-enrichment methodology for full-genome sequencing of Dengue 1-4, Chikungunya and Zika viruses directly from patient samples. PLoS Neglected Tropical Diseases. 13(4): e0007184, 2019. PMID: 31022183 

Lin-Fa Wang and Danielle E Anderson. Viruses in bats and potential spillover to animals and humans. Current Opinion in Virology, Feb;34:79-89, 2019. PMID: 30665189 

Xing-Lou Yang, Chee Wah Tan, Danielle E Anderson, Ren-Di Jiang, Bei Li, Wei Zhang, Yan Zhu, Xiao Fang Lim, Peng Zhou, Xiang-Ling Liu, Wuxiang Guan, Libiao Zhang, Shi-Yue Li, Yun-Zhi Zhang, Lin-Fa Wang and Zheng-Li Shi. Characterization of a filovirus (Měnglà virus) from Rousettus bats in China. Nature Microbiology. Mar;4(3):390-395, 2019. PMID: 30617348

Danielle E Anderson*, Ariful Islam*, Gary Crameri*, Shawn Todd, Ausraful Islam, Salah U Khan, Adam Foord, Mohammed Z Rahman, Ian H Mendenhall, Stephen P Luby, Emily S Gurley, Peter Daszak, Jonathan H Epstein, Lin-Fa Wang (*Authors contributed equally). Isolation and full-genome characterization of multiple Nipah viruses from bats, Bangladesh. Emerging Infectious Diseases. 25(1):166-170, 2019. PMID: 30561301 

Sheila Ommeh, Wei Zhang, Ali Zohaib, Jing Chen, Huajun Zhang, Ben Hu, Xing-Yi Ge, Xing-Lou Yang, Moses Masika, Vincent Obanda, Yun Luo, Shan Li, Cecilia Waruhiu, Bei Li, Yan Zhu, Desterio Ouma, Vincent Odendo, Lin-Fa Wang, Danielle E Anderson, Jacqueline Lichoti, Erick Mungube, Francis Gakuya, Peng Zhou, Kisa-Juma Ngeiywa, Bing Yan, Bernard Agwanda, Zheng-Li Shi. Genetic evidence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and widespread seroprevalence among camels in Kenya. Virologica Sinica, 33(6):484-492, 2018. PMID: 30570714 

Anna Uehara, Chee Wah Tan, Shailendra Mani, Kaw Bing Chua, Yee Sin Leo, Danielle E Anderson, Lin-Fa Wang. Serological evidence of human infection by bat orthoreovirus in Singapore. Journal of Medical Virology. 1-4, 2018. PMID: 30411364 

Shailendra Mani, Chee Wah Tan, Lin-Fa Wang, Danielle E Anderson. Serological Cross Reactivity Between Zika and Dengue Viruses in Experimentally Infected Monkeys. Virologica Sinica. 33(4), 378-381, 2018. PMID: 30155852 

Peng Zhou, Hang Fan, Tian Lan, Xing-Lou Yang, Wei-Feng Shi, Wei Zhang, Yan Zhu, Ya-Wei Zhang, Qing-Mei Xie, Shailendra Mani, Xiao-Shuang Zheng, Bei Li, Jin-Man Li, Hua Guo, Guang-Qian Pei, Xiao-Ping An, Jun-Wei Chen, Ling Zhou, Kai-jie Mai, Zi-Xian Wu, Di Li, Danielle E Anderson, Li-Biao Zhang, Shi-Yue Li, Zhi-Qiang Mi, Tong-Tong He, Feng Cong, Peng-Ju Guo, Ren Huang, Yun Luo, Xiang-Ling Liu, Jing Chen, Yong Huang, Qiang Sun, Xiang-Li-Lan Zhang, Yuan-Yuan Wang, Shao-Zhen Xing, Yan-Shan Chen, Yuan Sun, Juan LI, Peter Daszak, Lin-Fa Wang, Zheng-Li Shi, Yi-Gang Tong, Jing-Yun Ma. Fatal Swine Disease Outbreak Caused by a Novel HKU2-related Coronavirus of Bat Origin. Nature. 556(7700), 255-258., 2018. PMID: 29618817 

Takaaki Koma, Veljko Veljkovic, Danielle E Anderson, Lin-Fa Wang, Shannan L Rossi, Chao Shan, Pei-Yong Shi, David W Beasley, Natalya Bukreyeva, Jeanon N Smith, Steven Hallam, Cheng Huang, Veronika von Messling, Slobodan Paessler. Zika virus infection elicits auto-antibodies to C1q. Scientific Reports. 8(1), 1882, 2018. PMID: 29382894 

Zheng Jie Marc Ho, Hapuarachchige Chanditha Hapuarachchi, Timothy Barkham, Angela Chow, Lee Ching Ng, Jian Ming Vernon Lee, Yee Sin Leo, Kiesha Prem, Yue Hui Georgina Lim, Paola F de Sessions, Maia A. Rabaa, Chee Seng Chong, Cheong Huat Tan, Jayanthi Rajarethinam, Junhao Tan, Danielle E Anderson, Xinmei Ong, Alex R Cook, Chia Yin Chong, Li Yang Hsu, Grace Yap,Yee Ling Lai, Tanu Chawla, Louise Pan, Shuzhen Sim, I-Cheng Mark Chen, Koh Cheng Thoon, Chee Fu Yung, Jia Hui Li, Hee Ling Deborah Ng, Khine Nandar, Peng Lim Ooi, Raymond Tzer Pin Lin, Pauline Aw, Anna Uehara, Partha Pratim De, Wendy Soon, Martin Lloyd Hibberd, Huck Hui Ng, Sebastian Maurer-Stroh, October M Sessions. Outbreak of Zika in Singapore – An Epidemiological, Entomological, Virological and Clinical Account. The Lancet Infectious Diseases. 17(8), 813-21, 2017. PMID: 28527892 

Nicholas Svitek, Ingo Gerhauser, Christophe Goncalves, Elena Grabski, Marius Döring, Ulrich Kalinke, Danielle E Anderson, Roberto Cattaneo, Veronika von Messling. Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but Not STAT1 for Canine Distemper Virus Virulence in Ferrets. Journal of Virology. 88(5), 2941-50, 2014. PMID: 24371065 

Veljko M Nikolin, Klaus Osterrieder, Veronika von Messling, Heribert Hofer, Danielle Anderson, Edward Dubovi, Edgar Brunner, Marion L East. Antagonistic Pleiotropy and Fitness Trade-Offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus. PLoS ONE 7(12): e50955. 2012. PMID: 23239996

Danielle E Anderson, Edward J Dubovi, Meng Yu, Lin-Fa Wang, Randall W Renshaw. Genome characterization of Salem virus reveals its evolutionary intermediate status in the subfamily Paramyxovirinae. Archives of Virology, 157(10), 1989-93, 2012. PMID: 22729563

Danielle E Anderson, Alexandre Castan, Martin Bisaillon, Veronika von Messling. Elements in the Canine Distemper Virus M 3' UTR Contribute to Control of Replication Efficiency and Virulence. PLoS ONE, 7(2): e31561. 2012. PMID: 22348107 

Erik Dietzel*, Danielle E Anderson*, Alexandre Castan*, Veronika von Messling, Andrea Maisner. (*Authors contributed equally). Canine distemper virus matrix protein influences particle infectivity, particle composition, and envelope distribution in polarized epithelial cells and modulates virulence. Journal of Virology, 85(14), 7162-8, 2011. PMID: 21543493 

Zhuo Li, Jie Xu, Jui Patel, Sandra Fuentes, Yuan Lin, Danielle Anderson, Kaori Sakamoto, Lin-Fa Wang, Biao He. Function of the Small Hydrophobic Protein of J Paramyxovirus. Journal of Virology, 85(1), 32-42, 2011. PMID: 20980504

John Bingham, Diane J Green, Sue Lowther, Jessica Klippel, Simon Burggraaf, Danielle E Anderson, Hendra Wibawa, Dong Manh Hoa, Ngo Thanh Long, Pham Phong Vu, Deborah J Middleton, Peter W Daniels. Infection studies with two highly pathogenic avian influenza strains (Vietnamese and Indonesian) in Pekin ducks (Anas platyrhynchos), with particular reference to clinical disease, tissue tropism and viral shedding. Avian Pathology, 38 (4), 2009. PMID: 19937511 

Luke S Lambeth*, Meng Yu*, Danielle E Anderson*, Gary Crameri, Brian T Eaton, Lin-Fa Wang. (*Authors contributed equally). Complete genome sequence of Nariva virus, a rodent paramyxovirus. Archives of Virology, 154(2), 199-207, 2009. PMID: 19104752

Danielle E Anderson, Veronika von Messling. Region between the Canine Distemper virus M and F genes modulates virulence by controlling fusion protein expression. Journal of Virology, 82(21), 10510-10518, 2008. PMID: 18753197 

Philippa JM Jack, Danielle E Anderson, Katharine N Bossart, Glenn A Marsh, Meng Yu, Lin-Fa Wang. The expression of novel genes encoded by the paramyxovirus J-virus. Journal of General Virology, 89, 1434-1441, 2008. PMID: 18474559 

Chang Xiao, Yongjun Liu, Yu Jiang, Danielle E Magoffin, Huancheng Guo, Hua Xuan, Guiping Wang, Lin-Fa Wang, Changchun Tu. Monoclonal antibodies against the nucleocapsid proteins of henipaviruses: production, epitope mapping and application in immunohistochemistry. Archives of Virology, 153(2), 273-281, 2008. PMID: 17978885

Danielle E Magoffin, John S Mackenzie, Lin-Fa Wang. Genetic analysis of J-virus and Beilong virus using minireplicons. Virology, 364(1), 103-111, 2007. PMID: 17397895

Danielle E Magoffin, Kim Halpin, Paul A. Rota, Lin-Fa Wang. Effects of single amino acid substitutions at the E residue in the conserved GDNE motif of the Nipah virus polymerase (L) protein. Archives of Virology, 152(4), 827-832, 2007. PMID: 17143779 

Zhuo Li, Meng Yu, Hong Zhang, Danielle E Magoffin, Philippa JM Jack, Alex Hyatt, Hai-Yan Wang, Lin-Fa Wang. Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses. Virology, 346(1), 219-228, 2006. PMID: 16325221 

Patricia LM Dahia, Ke Hao, John Rogus, Christian Colin, Miguel A G Pujana, Ken Ross, Danielle Magoffin, Neil Aronin, Alberto Cascon, César Y Hayashida, Cheng Li, Sérgio P A Toledo, Charles D Stiles, Familial Pheochromocytoma Consortium. Novel Pheochromocytoma Susceptibility Loci Identified by Integrative Genomics. Cancer Research, 65(21), 9651-9658, 2005.PMID: 16266984