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Anderson Danielle Elizabeth

Assistant Professor

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Bio Research Publications

Dr Danielle Anderson is the Scientific Director of the Duke-NUS Medical School ABSL3 laboratory. In January 2020, Asst Prof Anderson and her team isolated SARS-CoV-2 from a clinical sample from one of the first COVID-19 patients in Singapore. From this, she helped to develop a test kit for COVID-19, which has vitally assisted the Singapore authorities with its contact tracing efforts.

Dr Anderson’s research interests include understanding the virus/host relationship of a diverse group of medically important negative-stranded RNA viruses that includes Measles virus, Mumps virus and Nipah virus. These paramyxoviruses are not only responsible for a high degree of morbidity and mortality worldwide but also cause encephalitis.  In addition, Dr Anderson utilises novel diagnostic platforms for the identification of not only new paramyxoviruses, but also other clinically relevant emerging infectious diseases, such as MERS and Zika virus.

Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM, Lau SK, Anderson DE, Chan KS, Tan TY, Ng TY, Cui L, Said Z, Kurupatham L, Chen MI, Chan M, Vasoo S, Wang LF, Tan BH, Lin RTP, Lee VJM, Leo YS, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. Mar 3. doi: 10.1001/jama.2020.3204. 2020.

Wang LF, Anderson DE, Mackenzie JS, Merson MH. From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses. Lancet. 22;395(10224):e33-e34. 2020.

Peng Zhou, Bei Li, Hao-rui Si, Yan Zhu, Xing-Lou Yang, Danielle E. Anderson, Zheng-Li Shi, and Lin-Fa Wang. Discovery of bat coronaviruses through surveillance and probe capture-based next generation sequencing. mSphere. 29;5(1). DOI: 10.1128/mSphere.00807-19. 2020.

Wei Zhang, Xiao-Shuang Zheng, Bernard Agwanda, Sheila Ommeh, Kai Zhao, Jacqueline Lichoti, Ning Wang, Jing Chen, Bei Li, Xing-Lou Yang, Shailendra Mani, Kisa-Juma Ngeiywa, Yan Zhu, Ben Hu, Samson Omondi Onyuok, Bing Yan, Danielle E. Anderson, Lin-Fa Wang, Peng Zhou, Zheng-Li Shi.  Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels. Emerging Microbes & Infections. 8(1):1528-1534. doi: 10.1080/22221751.2019.1679610. 2019.

Nagendrakumar B. Singanallura, Danielle E. Anderson, October M. Sessions, Uma S. Kamaraj, Timothy R. Bowden, Jacquelyn Horsington, Christopher Cowled, Lin-Fa Wang and Wilna Vosloo.  Probe capture enrichment next generation sequencing of complete foot-and-mouth disease virus genomes in clinical samples. Journal of Virological Methods. 272:113703. doi: 10.1016/j.jviromet.2019.113703, 2019.

Xiao Fang Lim, Chengfa Benjamin Lee, Sarah Marie Pascoe, Choon Beng How, Sharon Chan, Jun Hao Tan, Xinglou Yang, Peng Zhou, Zhengli Shi, October M. Sessions, Lin-Fa Wang, Lee Ching Ng, Danielle E. Anderson*, Grace Yap* (*Corresponding authors). Detection and characterization of a novel bat-borne coronavirus in Singapore using multiple molecular approaches. Journal of General Virology. Aug 16. doi: 10.1099/jgv.0.001307, 2019.

Chee Wah Tan, Kevin Wittwer, Xiao Fang Lim, Anna Uehara, Shailendra Mani, Lin-Fa Wang and Danielle E. Anderson. Serological evidence and experimental infection of cynomolgus macaques with pteropine orthoreovirus reveal monkeys as potential hosts for transmission to humans. Emerging Microbes and Infections. 8(1):787-795. doi: 10.1080/22221751.2019.1621668, 2019.

Theresa Enkirch, Svenja Sauber, Danielle E. Anderson,  Esther S Gan, Dimitar Kenanov, Sebastian Maurer-Stroh and Veronika von Messling. Identification and In Vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs with Broad Anti-Influenza A Activity. Frontiers in Immunology. 10:1097. doi: 10.3389/fimmu.2019.01097, 2019.

Danielle E. Anderson*, Kristin Pfeffermann*, So Young Kim, Bevan Sawatsky, James Pearson, Mikhail Kovtun, David L. Corcoran, Yvonne Krebs, Kristmundur Sigmundsson, Sharon F. Jamison, Zhen Zhen Joanna Yeo, Linda J. Rennick, Lin-Fa Wang, Pierre J. Talbot, W. Paul Duprex, Mariano A. Garcia-Blanco and Veronika von Messling (*Authors contributed equally). Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae. mBio. 10(3) e00826-19; DOI: 10.1128/mBio.00826-19, 2019.

Uma Sangumathi Kamaraj, Jun Hao Tan, Ong Xin Mei, Louise Pan, Tanu Chawla, Anna Uehara, Lin-Fa Wang, Eng Eong Ooi, Duane J. Gubler, Hasitha Tissera, Lee Ching Ng, Annelies Wilder-Smith, Paola  Florez de Sessions, Timothy Barkham, Danielle E. Anderson, October Michael Sessions. Application of a targeted-enrichment methodology for full-genome sequencing of Dengue 1-4, Chikungunya and Zika viruses directly from patient samples. PLoS Neglected Tropical Diseases. 13(4): e0007184. doi.org/10.1371/journal.pntd.0007184, 2019.

Lin-Fa Wang and Danielle E. Anderson. Viruses in bats and potential spillover to animals and humans. Current Opinion in Virology, 34, 79-89, 2019.

Xing-Lou Yang, Chee Wah Tan, Danielle E. Anderson, Ren-Di Jiang, Bei Li, Wei Zhang, Yan Zhu, Xiao Fang Lim, Peng Zhou, Xiang-Ling Liu, Wuxiang Guan, Libiao Zhang, Shi-Yue Li, Yun-Zhi Zhang, Lin-Fa Wang and Zheng-Li Shi. Characterization of a filovirus (Měnglà virus) from Rousettus bats in China. Nature Microbiology. doi: 10.1038/s41564-019-0398-5, 2019.

Danielle E. Anderson*, Ariful Islam*, Gary Crameri*, Shawn Todd, Ausraful Islam, Md. Salah Uddin Khan, Adam Foord, Md. Ziaur Rahman, Ian H. Mendenhall, Stephen P. Luby, Emily S. Gurley, Peter Daszak, Jonathan H. Epstein and Lin-Fa Wang (*Authors contributed equally). Isolation and full-genome characterization of multiple Nipah viruses from bats, Bangladesh. Emerging infectious Diseases. 25(1):166-170, 2019.

Sheila Ommeh, Wei Zhang, Ali Zohaib, Jing Chen, Huajun Zhang, Ben Hu, Xing-Yi Ge, Xing-Lou Yang, Moses Masika, Vincent Obanda, Yun Luo, Shan Li, Cecilia Waruhiu, Bei Li, Yan Zhu, Desterio Ouma, Vincent Odendo, Lin-Fa Wang, Danielle E. Anderson, Jacqueline Lichoti, Erick Mungube, Francis Gakuya, Peng Zhou, Kisa-Juma Ngeiywa, Bing Yan, Bernard Agwanda and Zheng-Li Shi. Genetic evidence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and widespread seroprevalence among camels in Kenya. Virologica Sinica, 33(6):484-492, 2018.

Anna Uehara, Chee Wah Tan, Shailendra Mani, Kaw Bing Chua, Yee Sin Leo, Danielle E. Anderson and Lin-Fa Wang Serological evidence of human infection by bat orthoreovirus in Singapore. Journal of Medical Virology. 1-4, 2018.

Shailendra Mani, Chee Wah Tan, Lin-Fa Wang and Danielle E. Anderson. Serological Cross Reactivity Between Zika and Dengue Viruses in Experimentally Infected Monkeys. Virologica Sinica. 33(4), 378-381, 2018.

Peng Zhou, Hang Fan, Tian Lan, Xing-Lou Yang, Wei-Feng Shi, Wei Zhang, Yan Zhu, Ya-Wei Zhang, Qing-Mei Xie, Shailendra Mani, Xiao-Shuang Zheng, Bei Li, Jin-Man Li, Hua Guo, Guang-Qian Pei, Xiao-Ping An, Jun-Wei Chen, Ling Zhou, Kai-jie Mai, Zi-Xian Wu, Di Li, Danielle E. Anderson, Li-Biao Zhang, Shi-Yue Li, Zhi-Qiang Mi, Tong-Tong He, Feng Cong, Peng-Ju Guo, Ren Huang, Yun Luo, Xiang-Ling Liu, Jing Chen, Yong Huang, Qiang Sun, Xiang-Li-Lan Zhang, Yuan-Yuan Wang, Shao-Zhen Xing, Yan-Shan Chen, Yuan Sun, Juan LI, Peter Daszak, Lin-Fa Wang, Zheng-Li Shi, Yi-Gang Tong, Jing-Yun Ma. Fatal Swine Disease Outbreak Caused by a Novel HKU2-related Coronavirus of Bat Origin. Nature. 556(7700), 255-258., 2018.

Takaaki Koma, Veljko Veljkovic, Danielle E. Anderson, Lin-Fa Wang, Shannan L. Rossi, Chao Shan, Pei-Yong Shi, David W. Beasley, Natalya Bukreyeva, Jeanon N. Smith, Steven Hallam, Cheng Huang, Veronika von Messling, and Slobodan Paessler. Zika virus infection elicits auto-antibodies to C1q. Scientific Reports. 8(1), 1882, 2018.

Zheng Jie Marc Ho, Hapuarachchige Chanditha Hapuarachchi, Timothy Barkham, Angela Chow, Lee Ching Ng, Jian Ming Vernon Lee , Yee Sin Leo, Kiesha Prem, Yue Hui Georgina Lim, Paola F de Sessions, Maia A. Rabaa, Chee Seng Chong, Cheong Huat Tan, Jayanthi Rajarethinam, Junhao Tan, Anderson, Danielle E., Xinmei Ong, Alex R Cook , Chia Yin Chong , Li Yang Hsu , Grace Yap,Yee Ling Lai, Tanu Chawla, Louise Pan, Shuzhen Sim, I-Cheng Mark Chen, Koh Cheng Thoon, Chee Fu Yung, Jia Hui Li, Hee Ling Deborah Ng, Khine Nandar, Peng Lim Ooi, Raymond Tzer Pin Lin, Pauline Aw, Anna Uehara, Partha Pratim De, Wendy Soon, Martin Lloyd Hibberd, Huck Hui Ng, Sebastian Maurer-Stroh, October M Sessions. Outbreak of Zika in Singapore – An Epidemiological, Entomological, Virological and Clinical Account. The Lancet Infectious Diseases. 17(8), 813-21, 2017.

Svitek Nicholas, Gerhauser Ingo, Goncalves Christophe, Grabski Elena, Döring Marius, Kalinke Ulrich, Anderson Danielle E., Cattaneo Roberto, von Messling Veronika. Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but Not STAT1 for Canine Distemper Virus Virulence in Ferrets. Journal of Virology. 88(5), 2941-50, 2014.

Nikolin, Veljko M., Osterrieder, Klaus, von Messling, Veronika, Hofer, Heribert, Anderson, Danielle E., Dubovi, Edward, Brunner, Edgar and East, Marion L. Antagonistic Pleiotropy and Fitness Trade-Offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus. PLoS ONE 7(12): e50955. doi:10.1371/journal.pone.0050955, 2012.

Anderson, Danielle E., Dubovi, Edward J., Yu, Meng, Wang, Lin-Fa and Renshaw, Randall W. Genome characterization of Salem virus reveals its evolutionary intermediate status in the subfamily Paramyxovirinae. Archives of Virology, 157(10), 1989-93, 2012.

Anderson, Danielle E., Castan, Alexandre, Bisaillon, Martin and von Messling, Veronika. Elements in the Canine Distemper Virus M 3' UTR Contribute to Control of Replication Efficiency and Virulence. PLoS ONE, 7(2): e31561. doi:10.1371/journal.pone.0031561, 2012.

Dietzel, Erik*, Anderson, Danielle E.*, Castan, Alexandre*, von Messling, Veronika, and Maisner, Andrea. (*Authors contributed equally). Canine distemper virus matrix protein influences particle infectivity, particle composition, and envelope distribution in polarized epithelial cells and modulates virulence. Journal of Virology, 85(14), 7162-8, 2011.

Li, Zhuo, Xu, Jie, Patel, Jui, Fuentes, Sandra, Lin, Yuan, Anderson, Danielle, Sakamoto, Kaori, Wang, Lin-Fa, and He, Biao. Function of the Small Hydrophobic Protein of J Paramyxovirus. Journal of Virology, 85(1), 32-42, 2011.

Bingham, John, Green, Diane J., Lowther, Sue, Klippel, Jessica, Burggraaf, Simon, Anderson, Danielle   E., Wibawa, Hendra, Hoa, Dong Manh, Long, Ngo Thanh, Vu, Pham Phong, Middleton, Deborah J. and Daniels, Peter W. Infection studies with two highly pathogenic avian influenza strains (Vietnamese and Indonesian) in Pekin ducks (Anas platyrhynchos), with particular reference to clinical disease, tissue tropism and viral shedding. Avian Pathology, 38 (4), 2009.

Lambeth, Luke*, Yu, Meng*, Anderson, Danielle. E.,*, Crameri, Gary, Eaton, Brian. T., Wang, Lin-Fa. (*Authors contributed equally). Complete genome sequence of Nariva virus, a rodent paramyxovirus. Archives of Virology, 154(2), 199-207, 2009.

Anderson, Danielle E., von Messling, Veronika. Region between the Canine Distemper virus M and F genes modulates virulence by controlling fusion protein expression. Journal of Virology, 82(21), 10510-10518, 2008.

Jack, Philippa J. M., Anderson, Danielle E., Bossart, Katharine N., Marsh, Glenn A., Yu, Meng., Wang, Lin-Fa. The expression of novel genes encoded by the paramyxovirus J-virus. Journal of General Virology 89, 1434-1441, 2008.

Xiao, Chang, Liu, Yongjun, Jiang, Yu, Magoffin, Danielle E., Guo, Huancheng, Xuan, Hua, Wang, Guiping, Wang, Lin-Fa, Tu , Changchun. Monoclonal antibodies against the nucleocapsid proteins of henipaviruses: production, epitope mapping and application in immunohistochemistry. Archives of Virology, 153(2), 273-281, 2008.

Magoffin, Danielle E., Mackenzie, John S., Wang, Lin-Fa. Genetic analysis of J-virus and Beilong virus using minireplicons. Virology 364(1), 103-111, 2007.

Magoffin, Danielle E., Halpin, Kim, Rota, Paul A., Wang Lin-Fa. Effects of single amino acid substitutions at the E residue in the conserved GDNE motif of the Nipah virus polymerase (L) protein. Archives of Virology 152(4), 827-832, 2007.

Li, Zhuo, Yu, Meng, Zhang, Hong, Magoffin, Danielle E., Jack, Philippa J. M., Hyatt, Alex, Wang, Hai-Yan, and Wang, Lin-Fa. Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses. Virology 346(1), 219-228, 2006.

Dahia, Patricia L. M., Hao, Ke, Rogus, John, Colin, Christian, Pujana, Miguel A. G., Ross, Ken, Magoffin, Danielle, Aronin, Neil, Cascon, Alberto, Hayashida, Cesar Y., Li, Cheng, Toledo, Sergio P. A., Stiles, Charles D., and for the Familial Pheochromocytoma Consortium. Novel Pheochromocytoma Susceptibility Loci Identified by Integrative Genomics. Cancer Research 65(21), 9651-9658, 2005.