Directory

Directory

Antonius M J Van Dongen

Adjunct Associate Professor, Signature Research Programme in Neuroscience & Behavioural Disorders

antonius.vandongen@duke-nus.edu.sg

65167075

About

Publications

Bio

Dr Antonius VanDongen is an Associate Professor at Duke University, USA. After completing his PhD in Biophysics at the University of Leiden in the Netherlands, he moved to Texas, USA, to work at Baylor College of Medicine. He started working at Duke University in 1992 and at the Duke-NUS Graduate Medical School in Singapore. His extensive background spans pharmacology, electrophysiology, molecular and cellular neurobiology, and computational neuroscience. He is also interested in drug development, and his current research interests include the role of the Arc (activity-regulated cytoskeleton) gene in Alzheimer’s disease and the development of related therapeutics.

Education

Doctor of Philosophy

Leiden University, Netherlands

Master of Science

Utrecht University, Netherlands

Bachelor of Science

Utrecht University, Netherlands

Publications

A Proteome-Wide Effect of PHF8 Knockdown on Cortical Neurons Shows Downregulation of Parkinson's Disease-Associated Protein Alpha-Synuclein and Its Interactors

Biomedicines – Oey, Nicodemus E., Lei Zhou, Christine Hui Shan Chan, Antonius M. J. VanDongen, and Eng King Tan (2023)

11 (2);

Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer's Disease

Biomedicines – Leung, How-Wing, Gabriel Foo, and Antonius VanDongen (2022)

10 (8);

Selective increase of correlated activity in Arc-positive neurons after chemically induced long-term potentiation in cultured hippocampal neurons

ENeuro – Jiang, Yuheng, and Antonius M. J. VanDongen (2021)

8 (6);

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer's Disease

ACS Biomater Sci Eng – Yin, Juan, and Antonius M. VanDongen (2021)

7 (1); 254-264

Familiarity Detection and Memory Consolidation in Cortical Assemblies

ENeuro – Zhang, Xiaoyu, Fang-Chin Yeh, Han Ju, Yuheng Jiang, Gabriel Foo Wei Quan, and Antonius M. J. VanDongen (2020)

7 (3);

Whole Brain White Matter Microstructure and Upper Limb Function: Longitudinal Changes in Fractional Anisotropy and Axial Diffusivity in Post-Stroke Patients

J Cent Nerv Syst Dis – Oey, Nicodemus Edrick, Geoffrey Sithamparapillai Samuel, Joseph Kai Wei Lim, Antonius Mj VanDongen, Yee Sien Ng, and Juan Zhou (2019)

Combining levodopa and virtual reality-based therapy for rehabilitation of the upper limb after acute stroke: pilot study Part II

Singapore Med J – Samuel, Geoffrey Sithamparapillai, Nicodemus Edrick Oey, Min Choo, Han Ju, Wai Yin Chan, Stanley Kok, Yu Ge, Antonius M. Van Dongen, and Yee Sien Ng (2017)

58 (10); 610-617

Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

Stem Cell Reports – Bhinge, Akshay, Seema C. Namboori, Xiaoyu Zhang, Antonius M. J. VanDongen, and Lawrence W. Stanton (2017)

8 (4); 856-869

The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells

PLoS One 12 – Leung, How-Wing, Gabriel Foo, Gokulakrishna Banumurthy, Xiaoran Chai, Sujoy Ghosh, Tora Mitra-Ganguli, and Antonius M. J. VanDongen (2017)

12 (8);

Familiarity Detection is an Intrinsic Property of Cortical Microcircuits with Bidirectional Synaptic Plasticity

ENeuro – Zhang, Xiaoyu, Han Ju, Trevor B. Penney, and Antonius M. J. VanDongen (2017)

4 (3);

miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1

BMC Genomics – Poon, Vivian Y., Minxia Gu, Fang Ji, Antonius M. VanDongen, and Marc Fivaz (2016)

17 (1);

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients

Cell Rep – Lin, Lin, Jonathan Göke, Engin Cukuroglu, Mark R. Dranias, Antonius M. J. VanDongen, and Lawrence W. Stanton (2016)

15 (11); 2411-2426

A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes

Mol Biol Cell – Tie, Hieng Chiong, Divyanshu Mahajan, Bing Chen, Li Cheng, Antonius M. J. VanDongen, and Lei Lu (2016)

27 (5); 848-861

Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons

J Neurosci – Ju, Han, Mark R. Dranias, Gokulakrishna Banumurthy, and Antonius M. J. VanDongen (2015)

35 (9); 4040-4051

Stimulus information stored in lasting active and hidden network states is destroyed by network bursts

Front Integr Neurosci – Dranias, Mark R., M Brandon Westover, Sidney Cash, and Antonius M. J. VanDongen (2015)

The methyl-CpG-binding domain (MBD) is crucial for MeCP2's dysfunction-induced defects in adult newborn neurons

Front Cell Neurosci – Zhao, Na, Dongliang Ma, Wan Ying Leong, Ju Han, Antonius VanDongen, Teng Chen, and Eyleen L. K. Goh (2015)

A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression

ENeuro – Oey, Nicodemus E., How Wing Leung, Rajaram Ezhilarasan, Lei Zhou, Roger W. Beuerman, Hendrika M. A. VanDongen, and Antonius M. J. VanDongen (2015)

2 (1);

Directory

Bio

Education

Doctor of Philosophy

Master of Science

Bachelor of Science

Publications

A Proteome-Wide Effect of PHF8 Knockdown on Cortical Neurons Shows Downregulation of Parkinson's Disease-Associated Protein Alpha-Synuclein and Its Interactors

Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer's Disease

Selective increase of correlated activity in Arc-positive neurons after chemically induced long-term potentiation in cultured hippocampal neurons

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer's Disease

Familiarity Detection and Memory Consolidation in Cortical Assemblies

Whole Brain White Matter Microstructure and Upper Limb Function: Longitudinal Changes in Fractional Anisotropy and Axial Diffusivity in Post-Stroke Patients

Combining levodopa and virtual reality-based therapy for rehabilitation of the upper limb after acute stroke: pilot study Part II

Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells

Familiarity Detection is an Intrinsic Property of Cortical Microcircuits with Bidirectional Synaptic Plasticity

miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients

A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes

Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons

Stimulus information stored in lasting active and hidden network states is destroyed by network bursts

The methyl-CpG-binding domain (MBD) is crucial for MeCP2's dysfunction-induced defects in adult newborn neurons

A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression

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