Duke-NUS Medical School

Directory

Cao Mian

Assistant Professor, Signature Research Programme in Neuroscience & Behavioural Disorders

mian.cao@duke-nus.edu.sg

65161096

About

Publications

Bio

Dr Cao Mian is an Assistant Professor in the Neuroscience and Behavioural Disorders programme at Duke-NUS Medical School. His research focuses on the functional relationship of several Parkinson’s disease genes with the endocytic traffic of synaptic vesicles. He earned his PhD in Biochemistry from the Hong Kong University of Science and Technology in 2009, and subsequently joined Dr Pietro De Camilli’s laboratory at Yale University/Howard Hughes Medical Institute as a Postdoctoral Associate in the Department of Cell Biology. He was then promoted to Associate Research Scientist in the Department of Neuroscience at Yale University in 2015.

Directory

Bio

Education

Doctor of Philosophy (Biochemistry)

Bachelor of Science

Publications

Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.

The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures.

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology.

PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors.

PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance.

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.

Upregulation of Parkin in endophilin mutant mice.

Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1.

Loss of SYNJ1 dual phosphatase activity leads to early onset refractory seizures and progressive neurological decline.

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9.

Directory

Bio

Education

Doctor of Philosophy (Biochemistry)

Bachelor of Science

Publications

Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.

The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures.

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology.

PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors.

PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance.

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.

Upregulation of Parkin in endophilin mutant mice.

Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1.

Loss of SYNJ1 dual phosphatase activity leads to early onset refractory seizures and progressive neurological decline.

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9.

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