Duke-NUS Medical School

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Chan Kok Yen, Jerry

Professor, SingHealth Duke-NUS Obstetrics & Gynaecology Academic Clinical Programme

Academic Vice Chair (Research), SingHealth Duke-NUS Obstetrics & Gynaecology Academic Clinical Programme

obgjchan@nus.edu.sg

About

Academic Contributions

Professional

Research Interests

Publications

Bio

Dr. Chan read Medicine at Trinity College Dublin, graduating with Honours and First in his class in 1997. He began his postgraduate residency in Manchester and London, England. He completed the rest of his OBGYN training in Singapore in 2009, and a fellowship in Reproductive Endocrinology and Infertility in 2011, and is a practising accredited specialist in in Assisted Reproductive Technique in KKH. He is a fellow of the Royal College of Obstetrician and Gynaecologist in London.

Dr. Chan completed a PhD in intrauterine stem cell therapies at Imperial College London (2006). Thereafter, he returned to Singapore and started the Experimental Fetal Therapy laboratory, with a primary focus in developing novel fetal molecular therapies in the form of gene transfer and stem cell transplantation. Since then, he has been continuously funded by major grant funding bodies for his research totaling S$27.3 million as PI and S$52.5 million as Co-I/collaborator, and has supervised over 15 PhD students successfully. He has published over 250 papers, including prestigious journals such as The Lancet, Nature, Nature Medicine, Cell, Science, Immunity, PNAS, Blood, Stem Cells among others. He was also recognised as a Clarivate Highly Cited Researcher in 2020 and is currently the youngest full Professor in OBGYN in Singapore.

Education

Member, Royal Coll of Obstet & Gynae

Royal College of Obstetricians & Gynaecologists, United Kingdom

Master of Arts

Trinity College, Dublin, United Kingdom

Bachelor of Med, Bachelor of Surg, Bachelor of Obstet

Trinity College, Dublin, Ireland

NUS Appointment(s)

Principal Investigator

Experimental Fetal Medicine Group, YLL SoM, NUS, Currently Active

Member

NUS Graduate School for Integrative Sciences and Engineering, Currently Active

Associate Professor (Joint)

OBGYN, Yong Loo Lin School of Medicine, Currently Active

Directory

Bio

Education

Member, Royal Coll of Obstet & Gynae

Master of Arts

Bachelor of Med, Bachelor of Surg, Bachelor of Obstet

NUS Appointment(s)

Principal Investigator

Member

Associate Professor (Joint)

Academic Contribution(s)

Outstanding Poster Presentation Award, to Dr Ryan Lee (CS Resident)

SingHealth Residency in Singhealth Execels (RISE) – Faculty Appreciation Award

Runner’s Up – Robert G Edward Prize Paper Award 2020

SingHealth Publish! Award (as First Author)

Cross Field – Highly Cited Researcher 2020 (for past decade 2009-2019)

Best Presentation, to Dr. Loy See Ling

Travel Award, to Ms Nuryanti Johana

SingHealth Publish! Award (to Loy See Ling as First Author for “Maternal circadian eating time and frequency are associated with blood glucose levels during pregnancy)

National Outstanding Clinician Scientist Resident Award 2017. Mentor to Dr. Ku Chee Wai, ACP OBGYN

Clinician Scientist Award (Senior Investigator)

Singapore Health Quality Service - Star Award

Best Oral Presentation: Maternal circadian eating time and frequency are associated with blood glucose levels during pregnancy. Awarded to Loy See Ling (PI - Jerry Chan)

Best Oral Presentation – on Functional characterization of the human fetal antigen presenting cell network. Awarded to Naomi McGovern (PI – Jerry Chan)

Outstanding Oral Presentation: Osteogenic Influences of Prostate Cancer Cells In Engineered Bone Niche. Awarded to Tamilselvan Sahana (TS, Jing Lim, JKY Chan, MSK Chong).

Singapore Health Quality Service Silver Award

Outstanding Poster Award - Awarded to Dr. Citra Mattar. (PI - Jerry Chan)

Best Basic Science Poster – Endometriosis Special Interest Group – CD26/DPPIV downregulation under hypoxia could enhance migration in endometrial stromal cells in endometriosis. Awarded to Ms Tan Chin Wen (Graduate Student).

Oral Poster Merit Award - CD26/DPPIV Downregulation in endometrial stromal cell migration in endometriosis. Awarded to Dr. Lee Yie Hou.

Distinguished Researcher Award

Travel Award – Endothelial Cell Forming Colony Optimisation of Culture. Awarded to Dr. Mark Chong (Research Fellow)

Best Oral Presentation (3rd) – Mesenchymal stem cells and Endothelial progenitor cells for vascularization and bone repair. Awarded to Ms. Julie Yeo (Graduate Student).

Young Investigator Award – (Best Overall) - Awarded to Dr. Mark Chong (Research Fellow)

Maurice Rosefelt Scholarship - Progenitors in Breast Milk

Young Investigator Award – Early Intrauterine Gene Therapy in Non-Human Primates. Awarded to Dr. Citra Mattar (Clinician Graduate Student).

Travel Award – A Look at the Mechanism Underlying Mesenchymal Stem Cell Homing. Awarded to Ms Joan Yang (Graduate Student).

Travel Award – A developmental role for circulating human endothelial progenitors in mid-trimester fetuses. Awarded to Dr. Mark Chong (Research Fellow)

Travel Award – Hypoxia and hfMSC niche. Awarded to Ms. Liu Yu Chun (Graduate Student)

Best Poster Award – Highly oriented films for tissue engineering. Prize awarded to Mr. Wang Zuyong (Graduate Student).

S. Arulkumaran Young Investigator Award – (Basic Sciences). Awarded to Ms. Liu Yu Chun (Graduate Student)

Benjamin Henry Sheares Best Oral Presentation (1st) – Mesenchymal stem cells for treatment of acute lung injury. Awarded to Dr. Mark Chong (Research Fellow)

Travel Award - Outcomes of AAV8 and AAV5-mediated Fetal Gene Transfer at 0.9G in Non-human primates. Awarded to Dr. Citra Mattar (Clinician Graduate Student).

Travel Award - Functional Improvement of Cerebellar Degeneration after Intra-Cerebellar Transplantation of Human Fetal Neural Stem Cells into Spinocerebellar Ataxia Type 3 Mice. Awarded to Dr. Fan Yiping (Research Fellow).

Travel Award - Dynamically priming human fetal mesenchymal stem cells for bone tissue engineering application - a comparative study of different bioreactor systems. Awarded to Dr. Zhang Zhi-Yong (Research Fellow).

Travel Award - Role of endothelial progenitor cells in bone tissue engineering. Awarded to Ms Liu Yuchun (Graduate Student).

Travel Award - Intrauterine Gene Transfer (IUGT) in early to mid-gestation mediates hFIX expression in Non-human Primates. Prize Awarded to Dr. Citra Mattar (Clinician Graduate Student).

22nd Benjamin Henry Sheares Memorial Lecture - Intrauterine Stem Cell Transplantation and Gene Therapy

Best Poster (Third Position). Migratory behavior of cells derived from eutopic endometrium in endometriosis under hypoxic microenvironment. . Awarded to Ms Tan Chin Wen (Graduate Student)

Young Scientist Award. Generating Vascularised Tissue-Engineered Bone Grafts: Endothelial Progenitor Cells in Vasculogenic and Osteogenic Priming of Human Fetal Mesenchymal Stem Cells. Awarded to Ms Liu Yuchun (Graduate Student).

Best Poster (Silver) – Biology of Endothelial Progenitor Cells in Mid-Trimester Fetal Circulation. Awarded to Dr. Mark Chong (Research Fellow).

Best Young Investigator Award - Intrauterine delivery of Adeno-associated viral vectors serotypes 5, 8 and 9 efficiently transduce the liver, nervous system and epithelia following intravenous delivery to the non-human primate fetus in late-gestation. Awa

Travel Award – The utility of AAV9 for targeting CNS, PNS, skeletal musculature and viscera after IUGT in the late gestation macaque fetus. Awarded to Citra Mattar (Clinician Graduate Student)

Best Poster - Coculture of human endothelial progenitor stem cells and bone marrow-derived human fetal MSC potentiates osteogenesis through paracrine activity in vitro and induces neovasculaogenesis within tissue engineered bone grafts in vivo. Awarded to

Young Investigator Award (Silver) - Late Gestation Intrauterine Gene Therapy with Self-Complementary Adeno-Associated Vectors achieves Long-term Transgene Expression in New-Born Cynomolgus Macaques. Awarded to Citra Mattar (Clinician Graduate Student)

Best Oral Presentation (Gold, Basic Sciences) - Treatment of large defect using tissue engineered bone grafts. Awarded to Dr. Zhang Zhi-Yong (Research Fellow).

Clinician Scientist Award - Intrauterine gene therapy for factor X deficiency in non-human primates

Helmut Reul Young Investigator Award - Antibody conjugation promotes endothelial progenitor cell attachment and haemocompatibility. Awarded to Mark Chong (Research Fellow)

Best Oral Presentation – Fetal Gene Transfer with Self-Complimentary Recombinant Adeno-Associated Vectors Achieves Long-Term Factor IX Expression in Non-Human Primates. Awarded to Citra Mattar (Clinician Graduate Student)

Best Paper Award in Automation – Automated haematopoietic stem cell harvesting machine (Group Prize)

Best Poster Award – In vitro maturation of large hfMSC-PCL/TCP bone tissue engineered construct through long term culture in a biaxial perfusion flow bioreactor. Awarded to Liu Yuchun (Graduate Student).

Best Poster Award (Graduate Student) - Superior Osteogenic Capacity for Bone Tissue Engineering of Fetal Compared with Perinatal and Adult Mesenchymal Stem Cells. Awarded to Zhang Zhiyong (Graduate Student)

Best Oral Presentation – The characterization of human fetal neural stem cells. Awarded to Dr. Citra Mattar (Clinician Graduate Student)

Best Abstracts Award – Awarded to Mr. Zhang Zhi Yong (Graduate Student)

Travel Award

Best Oral Presentation – Transduction Efficiency and Erythroid-lineage Specific Transgene Expression in an In-vitro Model of Thalassaemia, and its Application for Intrauterine Gene Therapy. Prize awarded to Dr. Citra Mattar (Clinician Graduate Student)

Vandenburg-Storz Prize for Best Young Investigator - Awarded to Dr. Citra Mattar (Clinician Graduate Student)

Merit Award – Best Oral Presentation (Basic Science). Awarded to Ms. Niraja Pandit (Research Fellow)

Travel Award. Awarded to Mr. Zhang Zhi Yong (Graduate Student)

Travel Award. Awarded to Mr. Mark Chong (Research Fellow)

Best Oral Presentation – In vivo evaluation of human fetal mesenchymal stem cells for bone tissue engineering. Prize awarded to Dr. Citra Mattar (Clinician Graduate Student)

Vandenburg-Storz Prize for Best Young Investigator

Exxon-Mobil-NUS Research Fellowship

Best Oral Presentation – Isolation of Ovarian Cancer Stem Cells

Best Oral Presentation (3rd Prize) – Iron labeling of stem cells for MRI tracking. Prize awarded to Mr. Eddy Lee (Graduate Student).

Best Oral Presentation (2nd Prize) – Breast Milk Stem Cells. Prize awarded to Ms Fan Yi Ping (Graduate Student).

Top 5 Abstract – Novel Biomarkers for Fetal Mesenchymal Stem Cells for Non-Invasive Prenatal Diagnosis

Best Oral Presentation – Fetal Endothelial Progenitor Cells

Vandenburg-Storz Prize for Best Young Investigator

Travel Award

Travel Award