Chen Huimei
Principal Research Scientist, Centre for Computational Biology
Nanjing University, China
Duke-NUS Medical School, Currently Active
Jingling Hospital, Nanjing, China, 07/2003 - 09/2006
Nanjing University/Department of Medical Genetics, Medical School, China, 10/2006 - 12/2009
Nanjing University, China/Department of Medical Genetics, Medical School, 01/2010 - 08/2016
Harvard Medical School, USA, 09/2010 - 03/2012
American Society of Nephrology, Currently Active
My research aims to provide a holistic view of the molecular mechanisms driving tissue fibrosis and to identify potential targets for therapeutic intervention, with a particular focus on kidney and lung fibrosis. I leverage multi-omics data, including genomics, transcriptomics, and metabolomics, to conduct systems biology research. By incorporating deep learning techniques, I aim to unravel the complexities of immune responses and the progression of tissue fibrosis, with the goal of identifying novel regulatory nodes. Furthermore, I utilize molecular biology, cell biology, and preclinical animal models to elucidate the roles and mechanisms of regulatory molecules in disease progression. Specifically, I study the functional roles of WWP2, which has been implicated in regulating key signaling pathways involved in fibrosis, including TGF-β signaling and metabolism. I am elucidating the precise mechanisms by which WWP2 and other regulatory molecules contribute to disease progression. This comprehensive understanding can inform the development of targeted therapeutic interventions.
I have three years of clinical experience, primarily managing patients with acute and chronic kidney diseases, encompassing a variety of primary renal diseases, autoimmune kidney diseases, and obesity-related diabetic nephropathy. I specialize in the detailed assessment of clinical features, pathological changes, and therapeutic strategies. The related experiences have been organized and published to contribute to the field's understanding of these conditions.
Nature communications – Chen Huimei; Moreno-Moral Aida; Pesce Francesco; Devapragash Nithya; Mancini Massimiliano; Heng Ee Ling; Rotival Maxime; Srivastava Prashant K; Harmston Nathan; Shkura Kirill; Rackham Owen J L; Yu Wei-Ping; Sun Xi-Ming; Tee Nicole Gui Zhen; Tan Elisabeth Li Sa; Barton Paul J R; Felkin Leanne E; Lara-Pezzi Enrique; Angelini Gianni; Beltrami Cristina; Pravenec Michal; Schafer Sebastian; Bottolo Leonardo; Hubner Norbert; Emanueli Costanza; Cook Stuart A; Petretto Enrico (2019)
10 (1);
Journal of the American Society of Nephrology : JASN – Chen Huimei; You Ran; Guo Jing; Zhou Wei; Chew Gabriel; Devapragash Nithya; Loh Jui Zhi; Gesualdo Loreto; Li Yanwei; Jiang Yuteng; Tan Elisabeth Li Sa; Chen Shuang; Pontrelli Paola; Pesce Francesco; Behmoaras Jacques; Zhang Aihua; Petretto Enrico (2024)
35 (6); 696-718
Nature communications – Chen Huimei; Chew Gabriel; Devapragash Nithya; Loh Jui Zhi; Huang Kevin Y; Guo Jing; Liu Shiyang; Tan Elisabeth Li Sa; Chen Shuang; Tee Nicole Gui Zhen; Mia Masum M; Singh Manvendra K; Zhang Aihua; Behmoaras Jacques; Petretto Enrico (2022)
13 (1);
Kidney international – Bai Mi; Chen Huimei; Ding Dan; Song Ruihua; Lin Jiajuan; Zhang Yuanyuan; Guo Yan; Chen Shuang; Ding Guixia; Zhang Yue; Jia Zhanjun; Huang Songming; He John Cijiang; Yang Li; Zhang Aihua (2019)
95 (6); 1389-1404
American journal of kidney diseases : the official journal of the National Kidney Foundation – Chen Hui-Mei; Li Shi-Jun; Chen Hui-Ping; Wang Qing-Wen; Li Lei-Shi; Liu Zhi-Hong (2008)
52 (1); 58-65
American journal of kidney diseases : the official journal of the National Kidney Foundation – Chen Hui-Mei; Liu Zhi-Hong; Zeng Cai-Hong; Li Shi-Jun; Wang Qing-Wen; Li Lei-Shi (2006)
48 (5); 772-9
Clinical journal of the American Society of Nephrology : CJASN – Shen Wen-wen; Chen Hui-mei; Chen Hao; Xu Feng; Li Lei-shi; Liu Zhi-hong (2010)
5 (8); 1401-9
Cell metabolism – Zhou Yi; Yu Xueqing; Chen Huimei; Sjöberg Sara; Roux Joséphine; Zhang Lijun; Ivoulsou Al-Habib; Bensaid Farid; Liu Cong-Lin; Liu Jian; Tordjman Joan; Clement Karine; Lee Chih-Hao; Hotamisligil Gokhan S; Libby Peter; Shi Guo-Ping (2015)
22 (6); 1045-58
Journal of immunology (Baltimore, Md. : 1950) – Zhou Yi; Chen Huimei; Liu Li; Yu Xueqing; Sukhova Galina K; Yang Min; Kyttaris Vasileios C; Stillman Isaac E; Gelb Bruce; Libby Peter; Tsokos George C; Shi Guo-Ping (2017)
198 (5); 1846-1854
Journal of immunology (Baltimore, Md. : 1950) – Zhou Yi; Chen Huimei; Liu Li; Yu Xueqing; Sukhova Galina K; Yang Min; Zhang Lijun; Kyttaris Vasileios C; Tsokos George C; Stillman Isaac E; Ichimura Takaharu; Bonventre Joseph V; Libby Peter; Shi Guo-Ping (2017)
198 (7); 2568-2577
Cardiovascular research – Zhang Jie; Chen Huimei; Liu Li; Sun Jiusong; Shi Michael A; Sukhova Galina K; Shi Guo-Ping (2012)
96 (3); 543-51
Free radical biology & medicine – Sun Caixia; Chen Huimei; Guo Wenwen; Zhang Kui; Qi Qiufeng; Gu Xin; Zhu Dalong; Wang Yaping (2010)
48 (3); 430-6
Molecular and cellular endocrinology – Chen Huimei; Sun Caixia; Guo Wenwen; Meng Ran; Du Hong; Qi Qiufeng; Gu Xin; Li Lirong; Zhang Kui; Zhu Dalong; Wang Yaping (2011)
332 (1-2); 301-305
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association – Zhao Weiwei; Ding Yin; Lu Jianping; Zhang Tao; Chen Dacheng; Zhang Haitao; Zeng Caihong; Liu Zhihong; Chen Huimei (2018)
33 (11); 1919-1927
American journal of nephrology – Zhang Tao; Lu Jianping; Liang Shaoshan; Chen Dachen; Zhang Haitao; Zeng Caihong; Liu Zhihong; Chen Huimei (2016)
43 (3); 160-169
Journal of human genetics – Ding Qiuju; Tan Amelia Li Min; Parra E J; Cruz Miguel; Sim Xueling; Teo Yik-Ying; Long Jirong; Alsafar Habiba; Petretto Enrico; Tai E-Shyong; Chen Huimei (2020)
65 (4); 411-420
The journal of gene medicine – Ding Qiuju; Zhao Weiwei; Long Jirong; Alsafar Habiba; Zhou Qing; Chen Huimei (2022)
24 (4);
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