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Pierce Chow Kah Hoe

Professor

Vice Chair, Research, Surgery Academic Clinical Programme

Email

Bio Research Publications

Education Qualifications: MBBS, MMed (Surg), FRCS (Edin), FAMS (Gen Surg), PhD 

Professor Chow is Senior Consultant and Co-Director (Surgical) of the Comprehensive Liver Cancer Clinic at National Cancer Centre Singapore, Senior Consultant Surgeon in Hepato-pancreato-biliary (HPB) and Transplant Surgery at Singapore General Hospital, Professor and Course Director at Duke-NUS Medical School Singapore.

Professor Chow was the Chapter of Surgeon’s Gold Medallist at the conjoint Royal College of Surgeons of Edinburgh/MMed (Surgery) examination in 1994 and subsequently completed a clinical fellowship in Liver Transplantation in Australia in 2000. In 2002 he was awarded his PhD.

In addition to managing a busy HPB surgical oncology service, Professor Chow has researched extensively on hepatocellular carcinoma (HCC). He leads collaborative research on the genomic heterogeneity of HCC and applications in precision medicine. He co-founded the Asia-Pacific Hepatocellular Carcinoma Trials Group in 1997 and has been the protocol chair of 7 multi-national prospective studies. In 2012 the National Medical Research Council Singapore conferred him the National Outstanding Clinician-Scientist Award for improving clinical outcomes of patients with his research on Liver Cancer.

Professor Chow was awarded the NMRC Translational-Clinical Research Grant for the Flagship Program in Liver Cancer in 2016 and has commenced the multi-national PLANET study (Precision Medicine in Liver Cancer Asia-Pacific Network). In 2017 he was awarded the country’s 1st IAF-PP grant from BMRC to develop the multi-institutional PuRPOSE Program to develop a clinically reliable and robust patient-specific diagnostic and predictive platform to improve treatment of liver cancer. Taken together, these studies will bring precision medicine to individuals with HCC and initiate new multi-national clinical studies across the Asia Pacific to advance treatment strategies for HCC.

Professional Appointments and Committee Memberships:                         

  • Professor and Program Director, Duke-NUS Medical School
  • Senior Consultant, Surgical Oncology, National Cancer Centre Singapore
  • Senior Consultant Surgeon, HPB/Transplant, Singapore General Hospital
  • President, College of Clinician Scientists, Academy of Medicine Singapore
  • Academic Vice Chair (Research), Academic Clinical Programme for Surgery (SURG ACP), SingHealth Duke-NUS Academic Medical Centre
  • Adjunct Senior Group Leader, Genome Institute of Singapore (GIS)
  • Research Director, Institute of Molecular Cell Biology (IMCB)
  • Protocol Chair, Asia-Pacific Hepatocellular Carcinoma Trials Group
  • Council, Asia-Pacific Primary Liver Cancer Expert Association
  • Council, Academy of Medicine Singapore 
  • Member, Research Training Review Panel, Specialists Accreditation Board, Ministry of Health Singapore
  • Member, Research Committee, Specialists Accreditation Board, Ministry of Health Singapore
  • Member, International Hepato-Pancreato-Biliary Association Scientific Committee

Awards:

  • National Day Awards, Long Service Medal (2016)
  • National Outstanding Clinician Scientist Award, NMRC (2012) 
  • Outstanding Educator Award, Duke-NUS Graduate Medical School (2010) 
  • Excellent Service Award (Gold), Healthcare. Spring Singapore (2004) 
  • Young Surgeon’s Award, Academy of Medicine, Singapore (1995)
  • Chapter of Surgeon’s Gold Medal Conjoint M.Med /FRCS (Edinburgh) (1994)

Leadership positions / roles in Education: 

  • Course Director, MD Program in Human Structure and Function, Duke-NUS Medical School Singapore
  • Program Director, PhD in Clinical Science, Duke-NUS Medical School Singapore
  • Chairman, Scientific Advisory Board, AUM Biosciences
  • Member, Scientific Advisory Board in HCC, AstraZeneca
  • Member, Scientific Advisory Board in HCC, Roche
  • Member, Scientific Input Engagement Board in HCC, MSD Pharma
  • Member, Expert Panel in HCC, BTG International Asia Ltd
  • Member, Scientific Advisory Board, New β Innovation Limited 
  • Chairman, Scientific Advisory Board for Hepatocellular Carcinoma,Ipsen Pharma
  • Chairman, Scientific Advisory Board for Hepatocellular Carcinoma, OncoSil Medical

Selected Publications (last 5 years):

Wu, L., Ferracci, G., Wang, Y., Fan, T.F., Cho, N., and Chow, P.K.H. (2019). Porcine hepatocytes culture on biofunctionalized 3D inverted colloidal crystal scaffolds as an in vitro model for predicting drug hepatotoxicity. RSC Adv., 2019, 9, 17995. doi: 10.1039/c9ra03225h

Kim, H., Worsley, O., Yang, E., Purbojati, R.W., Liang, A.L., Tan, W., Moses, D.I.D., Hartono, S., Fan, V., Lim, T.K.H., Schuster, S.C., Foo, R.S., Chow, P.K.H., and Pettersson, S. (2019). Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic-fatty liver disease. Cell Mol Life Sci. doi: 10.1007/s00018-019-03114-4.

Zhu, J.L., Yu, S.W.K., Chow, P.K.H., Tong, Y.W. and Li, J. (2018). Controlling Injectability and in Vivo Stability of Thermogelling Copolymers for Delivery of Yttrium-90 through Intra-Tumoral Injection for Potential Brachytherapy. Biomaterials 180, 163-172. 10.1016/j.biomaterials.2018.07.023.

Zhao, Y., Shuen, T.W.H., Toh, T.B., Chan, X.Y., Liu, M., Tan, S.Y., Fan, Y., Yang, H., Lyer, S.G., Bonney, G.K., Loh, E., Chang, K.T.E., Tan, T.C., Zhai, W., Chan, J.K.Y., Chow, E.K., Chee, C.E., Lee, G.H., Dan, Y.Y., Chow, P.K., Toh, H.C., Lim, S.G., and Chen, Q. (2018). Development of a New Patient-Derived Xenograft Humanised Mouse Model to Study Human-Specific Tumour Microenvironment and Immunotherapy. Gut 67(10):1845-1854. doi: 10.1136/gutjnl-2017-315201.

Grinchuk, O.V., Yenamandra, S.P., Iyer, R., Singh, M., Lee, H.K., Lim, K.H., Chow, P.K., and Kuznetsov, V.A. (2018). Tumor-Adjacent Tissue Co-Expression Profile Analysis Reveals Pro-Oncogenic Ribosomal Gene Signature for Prognosis of Resectable Hepatocellular Carcinoma. Mol Oncol 12, 89-113. 10.1002/1878-0261.12153.

Chow, P.K.H., Gandhi, M., Tan, S.B., Khin, M.W., Khasbazar, A., Ong, J., Choo, S.P., Cheow, P.C., Chotipanich, C., Lim, K., Lesmana, L.A., Manuaba, T.W., Yoong, B.K., Raj, A., Law, C.S., Cua, I.H.Y., Lobo, R.R., Teh, C.S.C., Kim, Y.H., Jong, Y.W., Han, H.S., Bae, S.H., Yoon, H.K., Lee, R.C., Hung, C.F., Peng, C.Y., Liang, P.C., Bartlett, A., Kok, K.Y.Y., Thng, C.H., Low, A.S., Goh, A.S.W., Tay, K.H., Lo, R.H.G., Goh, B.K.P., Ng, D.C.E., Lekurwale, G., Liew, W.M., Gebski, V., Mak, K.S.W., Soo, K.C., and Asia-Pacific Hepatocellular Carcinoma Trials, G. (2018). Sirvenib: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients with Hepatocellular Carcinoma. J Clin Oncol 36, 1913-1921. 10.1200/JCO.2017.76.0892.

Chew, V., Lee, Y.H., Pan, L., Nasir, N.J.M., Lim, C.J., Chua, C., Lai, L., Hazirah, S.N., Lim, T.K.H., Goh, B.K.P., Chung, A., Lo, R.H.G., Ng, D., Filarca, R.L.F., Albani, S., and Chow, P.K.H. (2018). Immune Activation Underlies a Sustained Clinical Response to Yttrium-90 Radioembolisation in Hepatocellular Carcinoma. Gut. 10.1136/gutjnl-2017-315485.

Cheung, T.T., Han, H.S., She, W.H., Chen, K.H., Chow, P.K.H., Yoong, B.K., Lee, K.F., Kubo, S., Tang, C.N., and Wakabayashi, G. (2018). The Asia Pacific Consensus Statement on Laparoscopic Liver Resection for Hepatocellular Carcinoma: A Report from the 7th Asia-Pacific Primary Liver Cancer Expert Meeting Held in Hong Kong. Liver Cancer 7, 28-39.10.1159/000481834.

Zhai, W., Lim, T.K., Zhang, T., Phang, S.T., Tiang, Z., Guan, P., Ng, M.H., Lim, J.Q., Yao, F., Li, Z., Ng, P.Y., Yan, J., Goh, B.K., Chung, A.Y., Choo, S.P., Khor, C.C., Soon, W.W., Sung, K.W., Foo, R.S., and Chow, P.K. (2017). The Spatial Organization of Intra-Tumour Heterogeneity and Evolutionary Trajectories of Metastases in Hepatocellular Carcinoma. Nat Commun 8, 4565. 10.1038/ncomms14565.

Pardo, F., Sangro, B., Lee, R.C., Manas, D., Jeyarajah, R., Donckier, V., Maleux, G., Pinna, A.D., Bester, L., Morris, D.L., Iannitti, D., Chow, P.K., Stubbs, R., Gow, P.J., Masi, G., Fisher, K.T., Lau, W.Y., Kouladouros, K., Katsanos, G., Ercolani, G., Rotellar, F., Bilbao, J.I., and Schoen, M. (2017). The Post-Sir-Spheres Surgery Study (P4s): Retrospective Analysis of Safety Following Hepatic Resection or Transplantation in Patients Previously Treated with Selective Internal Radiation Therapy with Yttrium-90 Resin Microspheres. Annals of surgical oncology 24, 2465-2473. 10.1245/s10434-017-5950-z.

Khaw, K.B., Choi, R.H., Kam, J.H., Chakraborty, B., and Chow, P.K. (2017). Interval Increase in the Prevalence of Symptomatic Cholelithiasis-Associated Non-Alcoholic Fatty Liver Disease over a Ten-Year Period in an Asian Population. Singapore Med J 58, 703-707. 10.11622/smedj.2016189.

Jusakul, A., Cutcutache, I., Yong, C.H., Lim, J.Q., Huang, M.N., Padmanabhan, N., Nellore, V., Kongpetch, S., Ng, A.W.T., Ng, L.M., Choo, S.P., Myint, S.S., Thanan, R., Nagarajan, S., Lim, W.K., Ng, C.C.Y., Boot, A., Liu, M., Ong, C.K., Rajasegaran, V., Lie, S., Lim, A.S.T., Lim, T.H., Tan, J., Loh, J.L., McPherson, J.R., Khuntikeo, N., Bhudhisawasdi, V., Yongvanit, P., Wongkham, S., Totoki, Y., Nakamura, H., Arai, Y., Yamasaki, S., Chow, P.K., Chung, A.Y.F., Ooi, L., Lim, K.H., Dima, S., Duda, D.G., Popescu, I., Broet, P., Hsieh, S.Y., Yu, M.C., Scarpa, A., Lai, J., Luo, D.X., Carvalho, A.L., Vettore, A.L., Rhee, H., Park, Y.N., Alexandrov, L.B., Gordan, R., Rozen, S.G., Shibata, T., Pairojkul, C., Teh, B.T., and Tan, P. (2017). Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma. Cancer Discov 7, 1116-1135. 10.1158/2159-8290.CD-17-0368.

Chow, P.K., Gandhi, M., and Gebski, V. (2017). The Sirvenib and Sarah Trials and the Role of Sir-Spheres(R) Y-90 Resin Microspheres in the Management of Hepatocellular Carcinoma. Future Oncol 13, 2213-2216. 10.2217/fon-2017-0395.

Chow, P.K., Choo, S.P., Ng, D.C., Lo, R.H., Wang, M.L., Toh, H.C., Tai, D.W., Goh, B.K., Wong, J.S., Tay, K.H., Goh, A.S., Yan, S.X., Loke, K.S., Thang, S.P., Gogna, A., Too, C.W., Irani, F.G., Leong, S., Lim, K.H., and Thng, C.H. (2016). National Cancer Centre Singapore Consensus Guidelines for Hepatocellular Carcinoma. Liver Cancer 5, 97-106. 10.1159/000367759.

Allen, J.C., Jr., Nault, J.C., Zhu, G., Khor, A.Y., Liu, J., Lim, T.K., Zucman-Rossi, J., and Chow, P.K. (2016). The Transcriptomic G1-G6 Signature of Hepatocellular Carcinoma in an Asian Population: Association of G3 with Microvascular Invasion. Medicine (Baltimore) 95, e5263. 10.1097/MD.0000000000005263.

Wang, W., Iyer, N.G., Tay, H.T., Wu, Y., Lim, T.K., Zheng, L., Song, I.C., Kwoh, C.K., Huynh, H., Tan, P.O., and Chow, P.K. (2015). Microarray Profiling Shows Distinct Differences between Primary Tumors and Commonly Used Preclinical Models in Hepatocellular Carcinoma. BMC Cancer 15, 828. 10.1186/s12885-015-1814-8.

Lim, K.C., Wang, V.W., Siddiqui, F.J., Shi, L., Chan, E.S., Oh, H.C., Tan, S.B., and Chow, P.K. (2015). Cost-Effectiveness Analysis of Liver Resection Versus Transplantation for Early Hepatocellular Carcinoma within the Milan Criteria. Hepatology 61, 227-237. 10.1002/hep.27135.

Chow, P.K., Poon, D.Y., Khin, M.W., Singh, H., Han, H.S., Goh, A.S., Choo, S.P., Lai, H.K., Lo, R.H., Tay, K.H., Lim, T.G., Gandhi, M., Tan, S.B., Soo, K.C., and Asia-Pacific Hepatocellular Carcinoma Trials, G. (2014). Multicenter Phase Ii Study of Sequential Radioembolization-Sorafenib Therapy for Inoperable Hepatocellular Carcinoma. PloS one 9, e90909. 10.1371/journal.pone.0090909.