Selected Publications (last 5 years):
Wu, L., Ferracci, G., Wang, Y., Fan, T.F., Cho, N., and Chow, P.K.H. (2019). Porcine hepatocytes culture on biofunctionalized 3D inverted colloidal crystal scaffolds as an in vitro model for predicting drug hepatotoxicity. RSC Adv., 2019, 9, 17995. doi: 10.1039/c9ra03225h
Kim, H., Worsley, O., Yang, E., Purbojati, R.W., Liang, A.L., Tan, W., Moses, D.I.D., Hartono, S., Fan, V., Lim, T.K.H., Schuster, S.C., Foo, R.S., Chow, P.K.H., and Pettersson, S. (2019). Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic-fatty liver disease. Cell Mol Life Sci. doi: 10.1007/s00018-019-03114-4.
Zhu, J.L., Yu, S.W.K., Chow, P.K.H., Tong, Y.W. and Li, J. (2018). Controlling Injectability and in Vivo Stability of Thermogelling Copolymers for Delivery of Yttrium-90 through Intra-Tumoral Injection for Potential Brachytherapy. Biomaterials 180, 163-172. 10.1016/j.biomaterials.2018.07.023.
Zhao, Y., Shuen, T.W.H., Toh, T.B., Chan, X.Y., Liu, M., Tan, S.Y., Fan, Y., Yang, H., Lyer, S.G., Bonney, G.K., Loh, E., Chang, K.T.E., Tan, T.C., Zhai, W., Chan, J.K.Y., Chow, E.K., Chee, C.E., Lee, G.H., Dan, Y.Y., Chow, P.K., Toh, H.C., Lim, S.G., and Chen, Q. (2018). Development of a New Patient-Derived Xenograft Humanised Mouse Model to Study Human-Specific Tumour Microenvironment and Immunotherapy. Gut 67(10):1845-1854. doi: 10.1136/gutjnl-2017-315201.
Grinchuk, O.V., Yenamandra, S.P., Iyer, R., Singh, M., Lee, H.K., Lim, K.H., Chow, P.K., and Kuznetsov, V.A. (2018). Tumor-Adjacent Tissue Co-Expression Profile Analysis Reveals Pro-Oncogenic Ribosomal Gene Signature for Prognosis of Resectable Hepatocellular Carcinoma. Mol Oncol 12, 89-113. 10.1002/1878-0261.12153.
Chow, P.K.H., Gandhi, M., Tan, S.B., Khin, M.W., Khasbazar, A., Ong, J., Choo, S.P., Cheow, P.C., Chotipanich, C., Lim, K., Lesmana, L.A., Manuaba, T.W., Yoong, B.K., Raj, A., Law, C.S., Cua, I.H.Y., Lobo, R.R., Teh, C.S.C., Kim, Y.H., Jong, Y.W., Han, H.S., Bae, S.H., Yoon, H.K., Lee, R.C., Hung, C.F., Peng, C.Y., Liang, P.C., Bartlett, A., Kok, K.Y.Y., Thng, C.H., Low, A.S., Goh, A.S.W., Tay, K.H., Lo, R.H.G., Goh, B.K.P., Ng, D.C.E., Lekurwale, G., Liew, W.M., Gebski, V., Mak, K.S.W., Soo, K.C., and Asia-Pacific Hepatocellular Carcinoma Trials, G. (2018). Sirvenib: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients with Hepatocellular Carcinoma. J Clin Oncol 36, 1913-1921. 10.1200/JCO.2017.76.0892.
Chew, V., Lee, Y.H., Pan, L., Nasir, N.J.M., Lim, C.J., Chua, C., Lai, L., Hazirah, S.N., Lim, T.K.H., Goh, B.K.P., Chung, A., Lo, R.H.G., Ng, D., Filarca, R.L.F., Albani, S., and Chow, P.K.H. (2018). Immune Activation Underlies a Sustained Clinical Response to Yttrium-90 Radioembolisation in Hepatocellular Carcinoma. Gut. 10.1136/gutjnl-2017-315485.
Cheung, T.T., Han, H.S., She, W.H., Chen, K.H., Chow, P.K.H., Yoong, B.K., Lee, K.F., Kubo, S., Tang, C.N., and Wakabayashi, G. (2018). The Asia Pacific Consensus Statement on Laparoscopic Liver Resection for Hepatocellular Carcinoma: A Report from the 7th Asia-Pacific Primary Liver Cancer Expert Meeting Held in Hong Kong. Liver Cancer 7, 28-39.10.1159/000481834.
Zhai, W., Lim, T.K., Zhang, T., Phang, S.T., Tiang, Z., Guan, P., Ng, M.H., Lim, J.Q., Yao, F., Li, Z., Ng, P.Y., Yan, J., Goh, B.K., Chung, A.Y., Choo, S.P., Khor, C.C., Soon, W.W., Sung, K.W., Foo, R.S., and Chow, P.K. (2017). The Spatial Organization of Intra-Tumour Heterogeneity and Evolutionary Trajectories of Metastases in Hepatocellular Carcinoma. Nat Commun 8, 4565. 10.1038/ncomms14565.
Pardo, F., Sangro, B., Lee, R.C., Manas, D., Jeyarajah, R., Donckier, V., Maleux, G., Pinna, A.D., Bester, L., Morris, D.L., Iannitti, D., Chow, P.K., Stubbs, R., Gow, P.J., Masi, G., Fisher, K.T., Lau, W.Y., Kouladouros, K., Katsanos, G., Ercolani, G., Rotellar, F., Bilbao, J.I., and Schoen, M. (2017). The Post-Sir-Spheres Surgery Study (P4s): Retrospective Analysis of Safety Following Hepatic Resection or Transplantation in Patients Previously Treated with Selective Internal Radiation Therapy with Yttrium-90 Resin Microspheres. Annals of surgical oncology 24, 2465-2473. 10.1245/s10434-017-5950-z.
Khaw, K.B., Choi, R.H., Kam, J.H., Chakraborty, B., and Chow, P.K. (2017). Interval Increase in the Prevalence of Symptomatic Cholelithiasis-Associated Non-Alcoholic Fatty Liver Disease over a Ten-Year Period in an Asian Population. Singapore Med J 58, 703-707. 10.11622/smedj.2016189.
Jusakul, A., Cutcutache, I., Yong, C.H., Lim, J.Q., Huang, M.N., Padmanabhan, N., Nellore, V., Kongpetch, S., Ng, A.W.T., Ng, L.M., Choo, S.P., Myint, S.S., Thanan, R., Nagarajan, S., Lim, W.K., Ng, C.C.Y., Boot, A., Liu, M., Ong, C.K., Rajasegaran, V., Lie, S., Lim, A.S.T., Lim, T.H., Tan, J., Loh, J.L., McPherson, J.R., Khuntikeo, N., Bhudhisawasdi, V., Yongvanit, P., Wongkham, S., Totoki, Y., Nakamura, H., Arai, Y., Yamasaki, S., Chow, P.K., Chung, A.Y.F., Ooi, L., Lim, K.H., Dima, S., Duda, D.G., Popescu, I., Broet, P., Hsieh, S.Y., Yu, M.C., Scarpa, A., Lai, J., Luo, D.X., Carvalho, A.L., Vettore, A.L., Rhee, H., Park, Y.N., Alexandrov, L.B., Gordan, R., Rozen, S.G., Shibata, T., Pairojkul, C., Teh, B.T., and Tan, P. (2017). Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma. Cancer Discov 7, 1116-1135. 10.1158/2159-8290.CD-17-0368.
Chow, P.K., Gandhi, M., and Gebski, V. (2017). The Sirvenib and Sarah Trials and the Role of Sir-Spheres(R) Y-90 Resin Microspheres in the Management of Hepatocellular Carcinoma. Future Oncol 13, 2213-2216. 10.2217/fon-2017-0395.
Chow, P.K., Choo, S.P., Ng, D.C., Lo, R.H., Wang, M.L., Toh, H.C., Tai, D.W., Goh, B.K., Wong, J.S., Tay, K.H., Goh, A.S., Yan, S.X., Loke, K.S., Thang, S.P., Gogna, A., Too, C.W., Irani, F.G., Leong, S., Lim, K.H., and Thng, C.H. (2016). National Cancer Centre Singapore Consensus Guidelines for Hepatocellular Carcinoma. Liver Cancer 5, 97-106. 10.1159/000367759.
Allen, J.C., Jr., Nault, J.C., Zhu, G., Khor, A.Y., Liu, J., Lim, T.K., Zucman-Rossi, J., and Chow, P.K. (2016). The Transcriptomic G1-G6 Signature of Hepatocellular Carcinoma in an Asian Population: Association of G3 with Microvascular Invasion. Medicine (Baltimore) 95, e5263. 10.1097/MD.0000000000005263.
Wang, W., Iyer, N.G., Tay, H.T., Wu, Y., Lim, T.K., Zheng, L., Song, I.C., Kwoh, C.K., Huynh, H., Tan, P.O., and Chow, P.K. (2015). Microarray Profiling Shows Distinct Differences between Primary Tumors and Commonly Used Preclinical Models in Hepatocellular Carcinoma. BMC Cancer 15, 828. 10.1186/s12885-015-1814-8.
Lim, K.C., Wang, V.W., Siddiqui, F.J., Shi, L., Chan, E.S., Oh, H.C., Tan, S.B., and Chow, P.K. (2015). Cost-Effectiveness Analysis of Liver Resection Versus Transplantation for Early Hepatocellular Carcinoma within the Milan Criteria. Hepatology 61, 227-237. 10.1002/hep.27135.
Chow, P.K., Poon, D.Y., Khin, M.W., Singh, H., Han, H.S., Goh, A.S., Choo, S.P., Lai, H.K., Lo, R.H., Tay, K.H., Lim, T.G., Gandhi, M., Tan, S.B., Soo, K.C., and Asia-Pacific Hepatocellular Carcinoma Trials, G. (2014). Multicenter Phase Ii Study of Sequential Radioembolization-Sorafenib Therapy for Inoperable Hepatocellular Carcinoma. PloS one 9, e90909. 10.1371/journal.pone.0090909.