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Vincenzo De Paola

Visiting Professor, Signature Research Programme in Neuroscience & Behavioural Disorders

Duke-NUS Medical School

Bio

The goal of my scientific research is to understand the regulation of neural network connectivity and function in the neocortex, a brain region affected in numerous developmental and degenerative diseases as well as acute injuries, which are incurable to date. To study complex genetic neuropsychiatric conditions such as Down syndrome, we are building more advanced human experimental in vivo cellular models. We focus on the role of the synaptic life cycle (i.e. synapse formation and elimination), and on the mechanisms of axon degeneration and regeneration. We combine human iPSC models, structural and functional imaging of in vivo self-assembled human cortical circuitry (as in Real et al 2018, complemented with human derived microglia), with state-of-the-art molecular and computational biology skills. 

I received a Ph.D. in molecular and cellular neurobiology from the University of Basel, Switzerland, for work in the laboratory of Dr. Pico Caroni at the Friedrich Miescher Institut, part of the Novartis foundation. I was then awarded an EMBO post-doctoral fellowship to train with Dr. Karel Svoboda at Cold Spring Harbor Laboratory, USA. Since 2008 I am honorary Group Leader at the MRC London Laboratory of Medical Sciences and a permanent member of the Faculty of Medicine of Imperial College London. In 2021 I joined the Neuroscience and Behavioural Disorders Programme at Duke-NUS, Singapore as Visiting Professor.

Education

Doctor of Philosophy

University of Basel, Switzerland, Switzerland

NUS Appointment(s)

Visiting Professor

Duke-NUS Medical School, Currently Active

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