Directory

Dr. Fan’s research primarily focuses on high-dimensional genomic data analysis and predictive modeling, gene and environment interactions, and genetic pleiotropy of multiple human traits. 

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

Nature communications – Fan Qiao; Verhoeven Virginie J M; Wojciechowski Robert; Barathi Veluchamy A; Hysi Pirro G; Guggenheim Jeremy A; Höhn René; Vitart Veronique; Khawaja Anthony P; Yamashiro Kenji; Hosseini S Mohsen; Lehtimäki Terho; Lu Yi; Haller Toomas; Xie Jing; Delcourt Cécile; Pirastu Mario; Wedenoja Juho; Gharahkhani Puya; Venturini Cristina; Miyake Masahiro; Hewitt Alex W; Guo Xiaobo; Mazur Johanna; Huffman Jenifer E; Williams Katie M; Polasek Ozren; Campbell Harry; Rudan Igor; Vatavuk Zoran; Wilson James F; Joshi Peter K; McMahon George; St Pourcain Beate; Evans David M; Simpson Claire L; Schwantes-An Tae-Hwi; Igo Robert P; Mirshahi Alireza; Cougnard-Gregoire Audrey; Bellenguez Céline; Blettner Maria; Raitakari Olli; Kähönen Mika; Seppala Ilkka; Zeller Tanja; Meitinger Thomas; ; Ried Janina S; Gieger Christian; Portas Laura; van Leeuwen Elisabeth M; Amin Najaf; Uitterlinden André G; Rivadeneira Fernando; Hofman Albert; Vingerling Johannes R; Wang Ya Xing; Wang Xu; Tai-Hui Boh Eileen; Ikram M Kamran; Sabanayagam Charumathi; Gupta Preeti; Tan Vincent; Zhou Lei; Ho Candice E H; Lim Wan'e; Beuerman Roger W; Siantar Rosalynn; Tai E-Shyong; Vithana Eranga; Mihailov Evelin; Khor Chiea-Chuen; Hayward Caroline; Luben Robert N; Foster Paul J; Klein Barbara E K; Klein Ronald; Wong Hoi-Suen; Mitchell Paul; Metspalu Andres; Aung Tin; Young Terri L; He Mingguang; Pärssinen Olavi; van Duijn Cornelia M; Jin Wang Jie; Williams Cathy; Jonas Jost B; Teo Yik-Ying; Mackey David A; Oexle Konrad; Yoshimura Nagahisa; Paterson Andrew D; Pfeiffer Norbert; Wong Tien-Yin; Baird Paul N; Stambolian Dwight; Wilson Joan E Bailey; Cheng Ching-Yu; Hammond Christopher J; Klaver Caroline C W; Saw Seang-Mei; Rahi Jugnoo S; Korobelnik Jean-François; Kemp John P; Timpson Nicholas J; Smith George Davey; Craig Jamie E; Burdon Kathryn P; Fogarty Rhys D; Iyengar Sudha K; Chew Emily; Janmahasatian Sarayut; Martin Nicholas G; MacGregor Stuart; Xu Liang; Schache Maria; Nangia Vinay; Panda-Jonas Songhomitra; Wright Alan F; Fondran Jeremy R; Lass Jonathan H; Feng Sheng; Zhao Jing Hua; Khaw Kay-Tee; Wareham Nick J; Rantanen Taina; Kaprio Jaakko; Pang Chi Pui; Chen Li Jia; Tam Pancy O; Jhanji Vishal; Young Alvin L; Döring Angela; Raffel Leslie J; Cotch Mary-Frances; Li Xiaohui; Yip Shea Ping; Yap Maurice K H; Biino Ginevra; Vaccargiu Simona; Fossarello Maurizio; Fleck Brian; Yazar Seyhan; Tideman Jan Willem L; Tedja Milly; Deangelis Margaret M; Morrison Margaux; Farrer Lindsay; Zhou Xiangtian; Chen Wei; Mizuki Nobuhisa; Meguro Akira; Mäkelä Kari Matti (2016)

7

HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization.

International journal of epidemiology – Fan Qiao; Maranville Joseph C; Fritsche Lars; Sim Xueling; Cheung Chui Ming Gemmy; Chen Li Jia; Gorski Mathias; Yamashiro Kenji; Ahn Jeeyun; Laude Augustinus; Dorajoo Rajkumar; Lim Tock Han; Teo Yik-Ying; Blaustein Robert O; Yoshimura Nagahisa; Park Kyu-Hyung; Pang Chi Pui; Tai E Shyong; Khor Chiea Chuen; Wong Tien Yin; Runz Heiko; Cheng Ching-Yu (2017)

46 (6); 1891-1902

Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians.

Journal of human genetics – Fan Qiao; Cheung Chui Ming Gemmy; Chen Li Jia; Yamashiro Kenji; Ahn Jeeyun; Laude Augustinus; Mathur Ranjana; Mun Chan Choi; Yeo Ian Y; Lim Tock Han; Teo Yik-Ying; Khor Chiea Chuen; Park Kyu-Hyung; Yoshimura Nagahisa; Pang Chi Pui; Wong Tien Yin; Cheng Ching-Yu (2017)

62 (12); 1049-1055

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.

Nature genetics – Tedja Milly S; Wojciechowski Robert; Hysi Pirro G; Eriksson Nicholas; Furlotte Nicholas A; Verhoeven Virginie J M; Iglesias Adriana I; Meester-Smoor Magda A; Tompson Stuart W; Fan Qiao; Khawaja Anthony P; Cheng Ching-Yu; Höhn René; Yamashiro Kenji; Wenocur Adam; Grazal Clare; Haller Toomas; Metspalu Andres; Wedenoja Juho; Jonas Jost B; Wang Ya Xing; Xie Jing; Mitchell Paul; Foster Paul J; Klein Barbara E K; Klein Ronald; Paterson Andrew D; Hosseini S Mohsen; Shah Rupal L; Williams Cathy; Teo Yik Ying; Tham Yih Chung; Gupta Preeti; Zhao Wanting; Shi Yuan; Saw Woei-Yuh; Tai E-Shyong; Sim Xue Ling; Huffman Jennifer E; Polašek Ozren; Hayward Caroline; Bencic Goran; Rudan Igor; Wilson James F; ; ; ; Joshi Peter K; Tsujikawa Akitaka; Matsuda Fumihiko; Whisenhunt Kristina N; Zeller Tanja; van der Spek Peter J; Haak Roxanna; Meijers-Heijboer Hanne; van Leeuwen Elisabeth M; Iyengar Sudha K; Lass Jonathan H; Hofman Albert; Rivadeneira Fernando; Uitterlinden André G; Vingerling Johannes R; Lehtimäki Terho; Raitakari Olli T; Biino Ginevra; Concas Maria Pina; Schwantes-An Tae-Hwi; Igo Robert P; Cuellar-Partida Gabriel; Martin Nicholas G; Craig Jamie E; Gharahkhani Puya; Williams Katie M; Nag Abhishek; Rahi Jugnoo S; Cumberland Phillippa M; Delcourt Cécile; Bellenguez Céline; Ried Janina S; Bergen Arthur A; Meitinger Thomas; Gieger Christian; Wong Tien Yin; Hewitt Alex W; Mackey David A; Simpson Claire L; Pfeiffer Norbert; Pärssinen Olavi; Baird Paul N; Vitart Veronique; Amin Najaf; van Duijn Cornelia M; Bailey-Wilson Joan E; Young Terri L; Saw Seang-Mei; Stambolian Dwight; MacGregor Stuart; Guggenheim Jeremy A; Tung Joyce Y; Hammond Christopher J; Klaver Caroline C W (2018)

50 (6); 834-848

A double-blind randomized placebo-controlled trial of probiotics in systemic sclerosis associated gastrointestinal disease.

Seminars in arthritis and rheumatism – Low Andrea Hsiu Ling; Teng Gim Gee; Pettersson Sven; de Sessions Paola Florez; Ho Eliza Xin Pei; Fan Qiao; Chu Collins Wenhan; Law Annie Hui Nee; Santosa Amelia; Lim Anita Yee Nah; Wang Yu Tien; Haaland Benjamin; Thumboo Julian (2019)

49 (3); 411-419

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.

Communications biology – Fan Qiao; Pozarickij Alfred; Tan Nicholas Y Q; Guo Xiaobo; Verhoeven Virginie J M; Vitart Veronique; Guggenheim Jeremy A; Miyake Masahiro; Tideman J Willem L; Khawaja Anthony P; Zhang Liang; MacGregor Stuart; Höhn René; Chen Peng; Biino Ginevra; Wedenoja Juho; Saffari Seyed Ehsan; Tedja Milly S; Xie Jing; Lanca Carla; Wang Ya Xing; Sahebjada Srujana; Mazur Johanna; Mirshahi Alireza; Martin Nicholas G; Yazar Seyhan; Pennell Craig E; Yap Maurice; Haarman Annechien E G; Enthoven Clair A; Polling JanRoelof; ; ; Hewitt Alex W; Jaddoe Vincent W V; van Duijn Cornelia M; Hayward Caroline; Polasek Ozren; Tai E-Shyong; Yoshikatsu Hosoda; Hysi Pirro G; Young Terri L; Tsujikawa Akitaka; Wang Jie Jing; Mitchell Paul; Pfeiffer Norbert; Pärssinen Olavi; Foster Paul J; Fossarello Maurizio; Yip Shea Ping; Williams Cathy; Hammond Christopher J; Jonas Jost B; He Mingguang; Mackey David A; Wong Tien-Yin; Klaver Caroline C W; Saw Seang-Mei; Baird Paul N; Cheng Ching-Yu (2020)

3 (1);

BTOB: Extending the Biased GWAS to Bivariate GWAS.

Frontiers in genetics – Zhu Junxian; Fan Qiao; Deng Wenying; Wang Yimeng; Guo Xiaobo (2021)

12

High-Density Lipoprotein 3 Cholesterol and Primary Open-Angle Glaucoma: Metabolomics and Mendelian Randomization Analyses.

Ophthalmology – Nusinovici Simon; Li Hengtong; Thakur Sahil; Baskaran Mani; Tham Yih-Chung; Zhou Lei; Sabanayagam Charumathi; Aung Tin; Silver David; Fan Qiao; Wong Tien Yin; Crowston Jonathan; Cheng Ching-Yu (2022)

129 (3); 285-294

Precisely modeling zero-inflated count phenotype for rare variants.

Genetic epidemiology – Fan Qiao; Sun Shuming; Li Yi-Ju (2022)

46 (1); 73-86

The effectiveness of Tuina in managing chronic non-specific low back pain: A protocol of a multicenter international randomized controlled trial.

Medicine – Zhou Xuan; Yang Juan; Ma Qing-Yu; Guo Yu; He Ke-Jie; Shen Long-Bin; Fan Qiao; Philip Cheong Kwok Chee; Keng Tay Boon; Celia Tan Ia Choo; Bauer Brent A; Chen Jia-Xu (2022)

101 (7);

Genetics, leadership position, and well-being: An investigation with a large-scale GWAS.

Proceedings of the National Academy of Sciences of the United States of America – Song Zhaoli; Li Wen-Dong; Jin Xuye; Ying Junbiao; Zhang Xin; Song Ying; Li Hengtong; Fan Qiao (2022)

119 (12);

Relationship Between Retinal Layer Thickness and Genetic Susceptibility to Age-Related Macular Degeneration in Asian Populations.

Ophthalmology science – Cheong Kai Xiong; Li Hengtong; Tham Yih Chung; Teo Kelvin Yi Chong; Tan Anna Cheng Sim; Schmetterer Leopold; Wong Tien Yin; Cheung Chui Ming Gemmy; Cheng Ching-Yu; Fan Qiao (2023)

3 (4);

Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes.

Nature communications – Fan Qiao; Li Hengtong; Wang Xiaomeng; Tham Yih-Chung; Teo Kelvin Yi Chong; Yasuda Masayuki; Lim Weng Khong; Kwan Yuet Ping; Teo Jing Xian; Chen Ching-Jou; Chen Li Jia; Ahn Jeeyun; Davila Sonia; Miyake Masahiro; Tan Patrick; Park Kyu Hyung; Pang Chi Pui; Khor Chiea Chuan; Wong Tien Yin; Yanagi Yasuo; Cheung Chui Ming Gemmy; Cheng Ching-Yu (2023)

14 (1);

A genome-wide association study of occupational creativity and its relations with well-being and career success.

Communications biology – Li Wen-Dong; Zhang Xin; Yu Kaili; Zhu Yimo; Du Nianyao; Song Zhaoli; Fan Qiao (2024)

7 (1);

Zim4rv: an R package to modeling zero-inflated count phenotype on regional-based rare variants.

BMC bioinformatics – Liu Xiaomin; Li Yi-Ju; Fan Qiao (2025)

26 (1);