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Hyunsoo Shawn Je

Associate Professor

Principal Investigator

Laboratory of Molecular Neurophysiology


Synapses are fundamental units of neuronal connectivity in the brain.  The Je laboratory investigates synapse for principles of learning and memory, for processes underlying animal behaviours, and for pathological mechanisms of various neurological and psychiatric disorders including autism, schizophrenia, Alzheimer’s disease and Parkinson's disease. 

1.  Khoo, A. T., Kim, P., Kim, H.M., and Je, H.S. (2020) Neural circuit analysis using a novel intersectional split intein-mediated split-Cre recombinase system.bioRxiv. doi:

2. Sun, A.X., Yuan, Q., Fukuda, M., Yu, W., Yan, H., Lim, G., Nai, M.H., D’Agostino, G.A., Tran, H.D., Itahana, Y., Wang, D., Lokman, H., Itahana, K., Lim, S., Tang, J., Chang, Y.Y., Zhang, M., Cook, S.A., Rackham, O.J.L., Lim, C.T., Tan, E.K., Ng, H.H., Lim, K.L., Jiang, Y.H., and Je, H.S. (2019) Potassium channel dysfunction in human neuronal models of Angelman syndrome. Science, 366, 1486-1492.  Previewed by Pamela Hines in the same issue of Science.

3.  Kim, B, Fukuda, M., Lee, J., Su., D., Sanu, S., Silvin, A., Khoo, A.T., Kwon, T., Liu, X., Chi, W., Liu, X., Choi, S., Wan, D., Park, S., Kim, J., Ginhoux, F., Je, H.S.#, and Chang, Y.T.# (2019) A novel fluorogenic chemical probe for direct identification and in vivo imaging of microglia. Angewandte Chemie, 131, 8056-8060. #: co-corresponding authors.  Cover illustration.

4. Tan, S., Xiao, Y., Yin, H.H., Chen, A.I., Soong, T.W., and Je, H.S. (2018) Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. PNAS. 115, E9909-E9915.

5. Husain, N., Yuan, Q., Yen, Y.C., Pletnikova, O., Dong, Q., Worley, P., Bichler, Z., and Je, H.S. (2017) TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation. Aging Cell, 16, 281-292.

6. Sun, A.X., Yuan, Q., Tan, S., Xiao, Y., Wang, D., Khoo, A.T., Sani L., Tran, H.D., Kim, P., Chiew, Y.S., Lee, K.J., Yen, Y.C., Ng, H.H., Lim, B., and Je, H.S. (2016) Direct induction and functional maturation of forebrain GABAergic neurons from human pluripotent stem cells. Cell Reports, 16, 1942-1953.

7. Jo, J., Xiao, Y., Sun, A.X., Cukuroglu, E., Tran, H.D., Goke, J., Tan, Z. Y., Saw, T. Y., Tan, C.P., Lokman, H., Lee, Y., Kim, D., Ko, H.S., Kim, S.O., Park, J. H., Cho, N.J., Hyde, T.M., Kleinman, J.E., Shin, J.H., Weinberger, D.R., Tan, E.K., Je, H.S.# and Ng, H.H.# (2016) Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin producing neurons. Cell Stem Cell, 19, 248-257. #: co-corresponding authors. Previewed by Marton and Paşca in the same issue of Cell Stem Cell.

8. Zhang, W., Kim, P., Chen, Z., Lokman, H., Qiu, L., Zhang, K., Rozen, S.G., Tan, E.K., Je, H.S.#, and Zeng, L.# (2016) MiRNA-128 Regulates the Proliferation and Neurogenesis of Neural Precursors by Targeting PCM1 in the Developing Cortex. eLIFE, 5, e11324 #: co-corresponding authors.

9. Yuan, Q., Yang, F., Husain, N., Ng, N., Tan, S., Kim, P., Han, W., Nagata, K., Weinberger, D.R., and Je, H.S. (2015) Regulation of BDNF exocytosis and GABAergic interneuron synapse function by the schizophrenia susceptibility gene, dysbindin-1. Biological Psychiatry, 80, 312-322. Cover illustration.

10. Mabb, A.M. *, Je, H.S. *, Wall, M.J., Robinson, C.G., Larsen, R.S., Qiang, Y., Correa, S.A., and Ehlers, M.D. (2014) Triad3A Regulates Synaptic Strength by Ubiquitination of Arc. Neuron, 82, 1299-316. *: co-first authors.

11. Je. H.S.#, Yang, F., Potluri, S., Ji.Y., Nagappan, G., Hempstead, B., Son, Y.J., and Lu, B.# (2013) proBDNF and Mature BDNF as Punishment and Reward Signals for Synapse Elimination at Mouse Neuromuscular Junctions. J. Neurosci. 33, 9957-62. #: co-corresponding authors.

12.Je, H.S., Yang, F., Potluri, S., Ji, Y., Nagappan, G., Hempstead, B., Son, Y.J., and Lu, B. (2012) Role of proBDNF to Mature BDNF Conversion in Activity-dependent Competition at Developing Neuromuscular Synapses. PNAS, 109, 15924-9. Highlighted in: Faculty of 1000 Biology, 18 Dec 2012.