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Je Hyun Soo Shawn

Associate Professor

Principal Investigator

Laboratory of Molecular Neurophysiology

Email

Contact: 66011260

Synapses are fundamental units of neuronal connectivity in the brain.  The Je laboratory investigates synapse for principles of learning and memory, for processes underlying animal behaviours, and for pathological mechanisms of various neurological and psychiatric disorders including autism, schizophrenia, Alzheimer’s disease and Parkinson's disease. 

Jo., J. Lin, Y., Tran, H.D., Yu, W., Sun, A.X., Chang, Y.Y., Jung, B.C., Lee, S.J., Saw, T.Y., Xiao, B., Khoo, A.T.T., Yaw, L.P., Xie, J. J., Lokman, H., Ong, W.Y, Lim, G.G.Y., Lim, K.L., Tan, E.K., Ng, H.H., and Je, H.S. (2021) Lewy-body Like Inclusions in Human Midbrain Organoid Carrying Glucocerebrosidase and Alpha Synuclein Mutations. Annals of Neurology, in press.

Cho, A., Jin, Y., An, Y., Jin, K., Choi, Y.S., Lee, J.S., Kim, J., Choi, W.Y, Koo, D.J., Yu, W., Chang, G.E., Kim, D.Y., Jo, S.H., Kim, J., Kim, S.Y., Kim, Y.G., Kim, J.Y., Choi, N., Cheong, E., Kim, Y.J., Je, H.S., Kang, H.C., and Cho, S.W. (2021) Combination of a microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids. Nature Comm., In press.

Khoo, A.T.T., Kim, P.J., Kim, H.M., and Je, H.S. (2020) Neural circuit analysis using a novel intersectional split intein-mediated split-Cre recombinase system. Molecular Brain, 13, 1-10.

Sun, A.X., Yuan, Q., Fukuda, M., Yu, W., Yan, H., Lim, G., Nai, M.H., D’Agostino, G.A., Tran, H.D., Itahana, Y., Wang, D., Lokman, H., Itahana, K., Lim, S., Tang, J., Chang, Y.Y., Zhang, M., Cook, S.A., Rackham, O.J.L., Lim, C.T., Tan, E.K., Ng, H.H., Lim, K.L., Jiang, Y.H., and Je, H.S. (2019) Potassium channel dysfunction in human neuronal models of Angelman syndrome. Science, 366, 1486-1492. Previewed by Pamela Hines in the same issue of Science.

Kim, B, Fukuda, M., Lee, J., Su., D., Sanu, S., Silvin, A., Khoo, A.T., Kwon, T., Liu, X., Chi, W., Liu, X., Choi, S., Wan, D., Park, S., Kim, J., Ginhoux, F., Je, H.S.#, and Chang, Y.T.# (2019) A novel fluorogenic chemical probe for direct identification and in vivo imaging of microglia. Angewandte Chemie, 131, 8056-8060. #: co-corresponding authors. Cover illustration.

Tan, S., Xiao, Y., Yin, H.H., Chen, A.I., Soong, T.W., and Je, H.S. (2018) Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. PNAS. 115, E9909-E9915.

Husain, N., Yuan, Q., Yen, Y.C., Pletnikova, O., Dong, Q., Worley, P., Bichler, Z., and Je,H.S. (2017) TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation. Aging Cell, 16, 281-292.

Jo, J., Xiao, Y., Sun, A.X., Cukuroglu, E., Tran, H.D., Goke, J., Tan, Z. Y., Saw, T. Y., Tan, C.P., Lokman, H., Lee, Y., Kim, D., Ko, H.S., Kim, S.O., Park, J. H., Cho, N.J., Hyde, T.M., Kleinman, J.E., Shin, J.H., Weinberger, D.R., Tan, E.K., Je, H.S.# and Ng, H.H.# (2016) Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin producing neurons. Cell Stem Cell, 19, 248-257. #: co- corresponding authors. Previewed by Marton and Paşca in the same issue of Cell Stem Cell.

Sun, A.X., Yuan, Q., Tan, S., Xiao, Y., Wang, D., Khoo, A.T., Sani L., Tran, H.D., Kim, P., Chiew, Y.S., Lee, K.J., Yen, Y.C., Ng, H.H., Lim, B., and Je, H.S. (2016) Direct induction and functional maturation of forebrain GABAergic neurons from human pluripotent stem cells. Cell Reports, 16, 1942-1953.