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Jens Marc Titze

Associate Professor

Email

Contact: 66011096

Bio Research Publications

Dr. Titze serves as Associate Professor at the Cardiovascular and Metabolic Disease Programme of Duke-NUS Medical School. He also holds appointments as a Professor for Electrolyte and Circulation Research at the Friedrich-Alexander-University of Erlangen-Nuremberg in Germany, and at the Division of Nephrology at Duke University, USA. He is an elected member of the American Society of Clinical Investigation and the European Academy of Sciences and Arts.

His research focuses on how the body organizes osmolyte metabolism to maintain body fluid homeostasis. His interdisciplinary clinician-scientist team conducts basic and clinical studies to understand how kidney, skin, liver and skeletal muscle coordinate their organ functions to achieve constant body fluid homeostasis.

Questioning traditional physiological concepts, we have begun to rethink therapeutic strategies against diabetes and hypertension. We also provide with new mechanistic insights into how the immune system protects against infection and tumors, and offer alternative views on the pathogenesis of autoimmune disease.
Our research teams work collaboratively in the clinical research and molecular physiology research domain. The molecular physiology projects headed by our junior research associates focus on how the kidney, the liver, skeletal muscle, the skin, and the immune system residing in the lymphatics interconnect into a physiological network that regulates salt and water homeostasis. The patient-oriented projects headed by our junior clinician research associates transfer these findings into clinical practice, relying on deep clinical phenotyping with innovative methods such as 23NaMRI imaging studies for non-invasive detection and quantification of otherwise hidden sodium stores in humans. This interdisciplinary science approach has resulted in new research avenues for current understanding of the underlying cause of diseases of the aging organism, such as arterial hypertension, diabetes mellitus, autoimmune disease and host defence, and muscle and bone loss.

1. Lankhorst S, Severs D, Markó L, Rakova N, Titze J, Müller DN, Danser AH, van den Meiracker AH. Salt sensitivity of angiogenesis inhibition-induced blood pressure rise: role of interstitial sodium accumulation? Hypertension. 2017 May;69(5):919-926. JIF:6.857, Times Cited: 2

2. Hammon M, Grossmann S, Linz P, Seuss H, Hammon R, Rosenhauer D, Janka R, Cavallaro A, Luft FC, Titze J, Uder M, Dahlmann A. 3 Tesla 23Na magnetic resonance imaging during acute kidney injury. Acad Radiol. 2017 May 8. pii: S1076-6332(17)30177-0. doi: 10.1016/j.acra.2017.03.012. [Epub ahead of print] JIF: 2.128, Times Cited: 0

3. Rakova N, Kitada K, Lerchl K, Dahlmann A, Birukov A, Daub S, Kopp C, Pedchenko T, Zhang Y, Beck L, Johannes B, Marton A, Müller DN, Rauh M, Luft FC, Titze J. Increased salt consumption induces body water conservation and decreases fluid intake. J Clin Invest. 2017; 127(5):1932-1943. JIF: 12.784, Times Cited: 3

4. Kitada K, Daub S, Zhang Y, Klein JD, Nakano D, Pedchenko T, Lantier L, LaRocque LM, Marton A, Neubert P, Schröder A, Rakova N, Jantsch J, Dikalova AE, Dikalov SI, Harrison DG, Müller DN, Nishiyama A, Rauh M, Harris RC, Luft FC, Wassermann DH, Sands JM, Titze J. High-salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation. J Clin Invest. 2017; 127(5):1944-1959. JIF: 12.784, Times Cited: 4

5. Hammon M, Grossmann S, Linz P, Seuss H, Hammon R, Rosenhauer D, Janka R, Cavallaro A, Luft FC, Titze J, Uder M, Dahlmann A. 3 Tesla 23Na magnetic resonance imaging during acute kidney injury. Acad Radiol. 2017 Sep;24(9):1086-1093.

6. Ansary TM, Fujisawa Y, Rahman A, Nakano D, Hitomi H, Kobara H, Masaki T, Titze JM, Kitada K, Nishiyama A. Responses of renal hemodynamics and tubular functions to acute sodium-glucose cotransporter 2 inhibitor administration in non-diabetic anesthetized rats. Sci Rep. 2017 Aug 25;7(1):9555.

7. Ott C, Kopp C, Dahlmann A, Schmid A, Linz P, Cavallaro A, Hammon M, Ditting T, Veelken R, Uder M, Titze J, Schmieder RE. Impact of renal denervation on tissue Na+ content in treatment-resistant hypertension. Clin Res Cardiol. 2017 Aug 28. doi: 10.1007/s00392-017-1156-4.

8. Barbaro NR, Foss JD, Kryshtal DO, Tsyba N, Kumaresan S, Xiao L, Mernaugh RL, Itani HA, Loperena R, Chen W, Dikalov S, Titze JM, Knollmann BC, Harrison DG, Kirabo A. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension. Cell Rep. 2017 Oct 24;21(4):1009-1020.

9. Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, Mähler A, Balogh A, Markó L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Frätzer C, Krannich A, Gollasch M, Grohme DA, Côrte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, Müller DN. Salt-responsive gut commensal modulates TH17 axis and disease. Nature. 2017 Nov 30;551(7682):585-589

10.  Carranza-Leon D, Octaria R, Ormseth MJ, Oeser A, Solus JF, Zhang Y, Okafor CR, Titze J, Michael Stein C, Chung CP. Association between urinary sodium and potassium excretion and blood pressure and inflammation in patients with rheumatoid arthritis. Clin Rheumatol. 2017 Dec 14. doi: 10.1007/s10067-017-3935-8. [Epub ahead of print]

11.  Karg MV, Bosch A, Kannenkeril D, Striepe K, Ott C, Schneider MP, Boemke-Zelch F, Linz P, Nagel AM, Titze J, Uder M, Schmieder RE. SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial. Cardiovasc Diabetol 2018 17:5

12. Crescenzi R, Marton A, Donahue PMC, Mahany HB, Lants SK, Wang P, Beckman JA, Donahue MJ, Titze J. Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema. Obesity (Silver Spring). 2018 Feb;26(2):310-317

13. Benz K, Schlote J, Daniel C, Kopp C, Dahlmann A, Schröder A, Cordasic N, Klanke B, Hilgers K, Titze J, Amann K. Mild salt-sensitive hypertension in genetically determined low nephron number is associated with chloride but not sodium retention. Kidney Blood Press Res. 2018 Jan 23;43(1):1-11

14. Speed JS, Hyndman KA, Kasztan M, Johnston JG, Roth KJ, Titze JM, Pollock DM. Diurnal pattern in skin Na+ and water content is associated with salt-sensitive hypertension in ETB receptor deficient rats. Am J Physiol Regul Integr Comp Physiol. Am J Physiol Regul Integr Comp Physiol. 2018 Apr 1;314(4):R544-R551.

15. Kopp C, Linz P, Maier C, Wabel P, Hammon M, Nagel AM, Rosenhauer D, Horn S, Uder M, Luft FC, Titze J*, Dahlmann A*. Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na-magnetic resonance imaging. Kidney Int. Kidney Int. 2018 May;93(5):1191-1197. (*shared last authorship).

16. Babaer D, Amara S, Ivy M, Zhao Y, Lammers PE, Titze JM, Tiriveedhi V. High salt induces P-glycoprotein mediated treatment resistance in breast cancer cells through store operated calcium influx. Oncotarget. 2018 May 18;9(38):25193-25205

17. Karlsen TV, Nikpey E, Han J, Reikvam T, Rakova N, Castorena-Gonzalez JA, Davis MJ, Titze JM, Tenstad O, Wiig H. High-Salt Diet Causes Expansion of the Lymphatic Network and Increased Lymph Flow in Skin and Muscle of Rats. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2054-2064.

18. Kopp C, Linz P, Maier C, Wabel P, Hammon M, Nagel AM, Rosenhauer D, Horn S, Uder M, Luft FC, Titze J, Dahlmann A. Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging. Kidney Int. 2018 May;93(5):1191-1197.

19. Neubert P, Weichselbaum A, Reitinger C, Schatz V, Schröder A, Ferdinand JR, Simon M, Bär AL, Brochhausen C, Gerlach RG, Tomiuk S, Hammer K, Wagner S, van Zandbergen G, Binger KJ, Müller DN, Kitada K, Clatworthy MR, Kurts C, Titze J, Abdullah Z, Jantsch J. HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting. Autophagy. 2019 Apr 14:1-18.

20. Cvetkovic L, Perisic S, Titze J, Jäck HM, Schuh W. The Impact of Hyperosmolality on Activation and Differentiation of B Lymphoid Cells. Front Immunol. 2019 Apr 18;10:828.