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Graves Nicholas


Deputy Director


Contact: 66012462

Prof Graves is the Deputy Director of the Programme in Health Services & Systems Research at Duke-NUS and the SingHealth Duke-NUS Health Services Research Institute. His areas of knowledge include health economics, health services research, decision making and cost-effectiveness. He is interested in projects that show high and low-value care, as well as the processes around implementing new policies.

His major focus is on showing how health services can be improved at low cost, or even improved with cost savings. He enjoys collaborating with clinicians who wish to improve the performance of health services.

Prof Graves has made contributions of international significance, publishing over 250 articles in top-ranking peer reviewed journals such as JAMA, BMJ, AIDS, Health Economics, Clinical Infectious Diseases, Lancet Infectious Diseases, The Journal of Infectious Diseases and Emerging Infectious Diseases.

Research Interest

Prof Graves is currently working on projects about the economic value of innovations in hospital-based services such as programmes to reduce risk of healthcare acquired infections, different approaches to testing cardiology outpatients and alternate treatment approaches for treating complex coronary artery disease. He is leading a qualitative study on why doctors believe non-beneficial treatments happen at the end of life. He is collaborating across all clusters to quantify the economic costs of chronic wounds to Singapore. And there are other projects on screening for paediatric genetic diseases, whether selective termination of resuscitation prehospital is a feasible and cost-effective policy and a project on inappropriate nephrotoxic Non-Steroidal Anti-Inflammatory Drug in Diabetics, Elderly and Renal impairment. He is developing a Graduate Certificate Programme in Health Services Innovation to be launched at Duke-NUS in 2020/21.

Research Team

Asst Prof Elaine Lum

Asst Prof Yoon Sungwon

Asst Prof Cai Yiying

Liu Sibo
Research Associate

Nazeha Nuraini
Research Assistant

  1. White NM, Barnett AG, Hall L, Mitchell BG, Farrington A, Halton K, Paterson DL, Riley TV, Gardner A, Page K, Gericke CA, Graves N. Cost-effectiveness of an environmental cleaning bundle for reducing healthcare associated infections. Clin Infect Dis. 2019 Jul 30. pii: ciz717. doi: 10.1093/cid/ciz717. [Epub ahead of print] PubMed PMID: 31359053.
  2. Chalmers AW, Patel S, Boucher K, Cannon L, Esplin M, Luckart J, Graves N, Van Duren T, Akerley W. Phase I Trial of Targeted EGFR or ALK Therapy with Ipilimumab in Metastatic NSCLC with Long-Term Follow-Up. Target Oncol. 2019 Jul 25. doi: 10.1007/s11523-019-00658-0. [Epub ahead of print] PubMed PMID: 31346927.
  3. Mitchell BG, Cheng AC, Fasugba O, Gardner A, Graves N, Koerner J, Collignon P. Chlorhexidine for prevention of catheter-associated urinary tract infections: the totality of evidence - Authors' reply. Lancet Infect Dis. 2019 Aug;19(8):808-809. doi: 10.1016/S1473-3099(19)30349-4. PubMed PMID: 31345452.
  4. Blythe R, Kularatna S, White N, Graves N, Clark K, Middleton H, Grimley R. Fits, faints, falls and funny turns: cost and capacity savings in Queensland from the accelerated transient attack pathway initiative (ATAP). Age Ageing. 2019 Jul 12. pii: afz086. doi: 10.1093/ageing/afz086. [Epub ahead of print] PubMed PMID: 31297515.
  5. Senanayake S, Mahesh PKB, Gunawardena N, Graves N, Kularatna S. Validity and internal consistency of EQ-5D-3L quality of life tool among pre-dialysis patients with chronic kidney disease in Sri Lanka, a lower middle-income country. PLoS One. 2019 Jun 26;14(6):e0211604. doi: 10.1371/journal.pone.0211604. eCollection 2019. PubMed PMID: 31242189; PubMed Central PMCID: PMC6594575.
  6. Stewart S, Robertson C, Manoukian S, Haahr L, Mason H, McFarland A, Dancer S, Cook B, Reilly J, Graves N; ECONI Steering Committee. How do we evaluate the cost of nosocomial infection? The ECONI protocol: an incidence study with nested case-control evaluating cost and quality of life. BMJ Open. 2019 Jun 19;9(6):e026687. doi: 10.1136/bmjopen-2018-026687. PubMed PMID: 31221878; PubMed Central PMCID: PMC6588979.
  7. Pacella RE, Tulleners R, McCosker L, Cheng Q, Harding K, Edwards H, Yelland S, Dyer A, McGuiness W, Graves N. Reimbursement for the cost of compression therapy for the management of venous leg ulcers in Australia. Int Wound J. 2019 Aug;16(4):1069-1072. doi: 10.1111/iwj.13152. Epub 2019 May 29. PubMed PMID:31140713.
  8. Mitchell BG, Fasugba O, Cheng AC, Gregory V, Koerner J, Collignon P, Gardner A, Graves N. Chlorhexidine versus saline in reducing the risk of catheter associated urinary tract infection: A cost-effectiveness analysis. Int J Nurs Stud. 2019 Apr 13;97:1-6. doi: 10.1016/j.ijnurstu.2019.04.003. [Epub ahead of print] PubMed PMID: 31129443.
  9. Close E, White BP, Willmott L, Gallois C, Parker M, Graves N, Winch S. Doctors' perceptions of how resource limitations relate to futility in end-of-life decision making: a qualitative analysis. J Med Ethics. 2019 Jun;45(6):373-379. doi: 10.1136/medethics-2018-105199. Epub 2019 May 15. PubMed PMID: 31092631.
  10. Obermair A, Armfield NR, Graves N, Gebski V, Hanna GB, Coleman MG, Hughes A, Janda M. How to train practising gynaecologists in total laparoscopic hysterectomy: protocol for the stepped-wedge IMAGINE trial. BMJ Open. 2019 May 9;9(5):e027155. doi: 10.1136/bmjopen-2018-027155. PubMed PMID: 31072858; PubMed Central PMCID: PMC6528001.