Duke-NUS Medical School

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Ooi Yaw Shin

Assistant Professor, Signature Research Programme in Emerging Infectious Diseases

yawshin.ooi@duke-nus.edu.sg

About

Professional

Teaching

Publications

Bio

Yaw Shin Ooi, PhD, is an Assistant Professor in the Emerging Infectious Diseases (EID) Programme at Duke-NUS Medical School. He received his PhD from Albert Einstein College of Medicine in New York, under the mentorship of Dr. Margaret Kielian, and completed his postdoctoral training with Dr. Jan Carette at Stanford University.

His research focuses on identifying host cellular factors that influence susceptibility to viral infection—specifically, host dependency factors that viruses hijack to enter cells and replicate, as well as restriction factors that constitute the host's innate antiviral defenses. These virus-host interactions determine whether infection proceeds or is halted by the immune response.

Currently, his lab investigates the molecular mechanisms underlying infections by medically important RNA viruses, with a particular emphasis on mosquito-borne viruses (including Alphaviruses and Flaviviruses) and respiratory viruses (such as Paramyxoviruses and Orthoreoviruses).

For more information, please visit the lab website.

Education

Doctor of Philosophy

Yeshiva University, United States

Master of Science

Yeshiva University, United States

Master of Science

University of Malaya, Malaysia

BSc (Genet & Molecular Bio) Hons w Dist

University of Malaya, Malaysia

Directory

Bio

Education

Doctor of Philosophy

Master of Science

Master of Science

BSc (Genet & Molecular Bio) Hons w Dist

Professional Appointment(s)

Research Assistant

Postdoctoral Fellow

Adjunct Investigator

Membership

Member

Editor

Member

Teaching

Publications

How a tick-borne virus enters human cells.

Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses.

MFSD6 is an entry receptor for enterovirus D68.

GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes.

A review of virus host factor discovery using CRISPR screening.

Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor.

TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection.

A fast-growing dengue virus mutant reveals a dual role of STING in response to infection.

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.

Know your enemy and know yourself - the case of SARS-CoV-2 host factors.

A memory of eS25 loss drives resistance phenotypes.

An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection.

Enterovirus Pathogenesis Requires the Host Methyltransferase SETD3.

SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

STAG2 deficiency induces IFN responses via cGAS-STING pathway and restricts virus infection.

A CRISPR toolbox to study virus-host interactions.

A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity.

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.

BST2/Tetherin inhibits alphavirus exit.

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry.

Directory

Bio

Education

Doctor of Philosophy

Master of Science

Master of Science

BSc (Genet & Molecular Bio) Hons w Dist

Professional Appointment(s)

Research Assistant

Postdoctoral Fellow

Adjunct Investigator

Membership

Member

Editor

Member

Teaching

Publications

How a tick-borne virus enters human cells.

Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses.

MFSD6 is an entry receptor for enterovirus D68.

GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes.

A review of virus host factor discovery using CRISPR screening.

Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor.

TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection.

A fast-growing dengue virus mutant reveals a dual role of STING in response to infection.

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.

Know your enemy and know yourself - the case of SARS-CoV-2 host factors.

A memory of eS25 loss drives resistance phenotypes.

An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection.

Enterovirus Pathogenesis Requires the Host Methyltransferase SETD3.

SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

STAG2 deficiency induces IFN responses via cGAS-STING pathway and restricts virus infection.

A CRISPR toolbox to study virus-host interactions.

A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity.

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.

BST2/Tetherin inhibits alphavirus exit.

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry.

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