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Salvatore Albani

Professor

Senior Consultant, Division of Medicine, KK Women's and Children's Hospital

Senior Clinical Scientist, KK Women's and Children's Hospital

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Education Qualifications: MD, PhD

Professor Salvatore Albani is an internationally renowned rheumatologist and immunologist.  He is a Professor at Duke-NUS Medical School and Director of the Translational Immunology Institute at SingHealth- Duke-NUS Medical Centre.   Before joining Duke-NUS, Professor Albani served as director of the Translational Medicine Unit at the Clinical Investigation Institute at the University of California, San Diego, where he also was professor of Medicine and Pediatrics.  His fundamental research interest is in understanding human immunity and contributing the knowledge to therapeutic and diagnostic advancements.  He has developed several innovative approaches in the area of induction and maintenance of immune tolerance in humans, being responsible for the whole translational process from idea to the conclusion of a Phase II clinical trial in autoimmune inflammatory diseases, which have a large impact on society and individuals.

He has been responsible for conception and execution of each of the stages of this complex itinerary, which spans a wide and diverse gradient of technologies and challenges. These include molecular immunology, lead identification and validation, intellectual property, CMC (Chemistry, Manufacturing and Controls), IND (Investigational New Drug filings), trial design, data management and analysis, interfacing with Venture Capital and Pharma, leading complex groups in a multi-center setting, etc.  The technology platform has applications in diseases that could benefit from a restoration of immune tolerance. This translational research itinerary has been the original backbone of his career, as witnessed by a rich publication trail (among others Nature Medicine, Lancet, JCI, PNAS, Nature Rheumatology, A&R, ARD, etc, H factor 34) and by approximately 100 patents. Development of high throughput technology platforms is also part of his scientific career. These platforms aim to provide tools for knowledge-based diagnostic and therapeutic decisions.

In his role as an educator, it has been his privilege to mentor many talented individuals, and to provide the right challenges and learning opportunities to help them grow and advance. He seeks to expand this even further by helping to create and nurture the next generation of translational scientists. 

Professional Appointments and Committee Memberships: 

  • Director, Translational Immunology Institute
  • UCAN-A Chair, President, Eureka Institute

Awards:

  • Nature Biotechnology, Outstanding Research Achievement Award, 2012
  • NMRC, Singapore Translational Research (STaR) Investigator Award, 2013
  • SingHealth Excellence Distinguished Researcher Award, 2019

Research Interests: Understanding human immunity and contributing the knowledge to therapeutic and diagnostic advancements.

Selected Publications:

Anissa A. Widjaja, Brijesh K. Singh, Eleonora Adami, Sivakumar Viswanathan, Jinrui Dong, Giuseppe A. D’Agostino, Benjamin Ng, Wei Wen Lim, Jessie Tan, Bhairav S. Paleja, Madhulika Tripathi, Sze Yun Lim, Shamini Guna Shekeran, Sonia P. Chothani, Anne Rabes, Martina Sombetzki, Eveline Bruinstroop, Lio Pei Min, Rohit A. Sinha, Salvatore Albani, Paul M. Yen, Sebastian Schafer, Stuart A. Cook. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis . Gastroenterology. doi.org/10.1053/j.gastro.2019.05.002 May, 2019

Charles-Antoine Dutertre, Etienne Becht, Sergio Erdal Irac, Ahad Khalilnezhad, Vipin Narang, Shabnam Khalilnezhad, Pei Y. Ng, Lucas L. van den Hoogen, Jing Yao Leong, Bernett Lee, Marion Chevrier, Xiao Meng Zhang, Pearly Jean Ai Yong, Geraldine Koh, Josephine Lum, Shanshan Wu Howland, Esther Mok, Jinmiao Chen, Anis Larbi, Henry Kun Kiaang Tan, Tony Kiat Hon Lim, Panagiota Karagianni, Athanasios G. Tzioufas, Benoit Malleret, Joshua Brody, Salvatore Albani, Joel van Roon, Timothy Radstake, Evan W. Newell, Florent Ginhoux. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells. Immunity. doi.org/10.1016/j.immuni.2019.08.08

Jing Yao Leong,  Phyllis Chen,  Joo Guan Yeo, Fauziah Ally, Camillus Chua,  Sharifah Nur Hazirah,  Su Li Poh,  Lu Pan, Liyun Lai, Elene Seck Choon Lee, Loshinidevi D/o Thana Bathi, Thaschawee Arkachaisri, Daniel Lovell,  Salvatore Albani, Pediatric rheumatology collaborative study Group. An immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFα withdrawal.  Annals of Rheumatic Diseases (ARD). 2019 Sept. 22 doi.org/10.1136/ annrheumdis-2019-216059

Judith Ju Ming Wong, Jing Yao Leong, Jan Hau Lee, Salvatore Albani, Joo Guan Yeo.  Insights into the immuno-pathogenesis of acute respiratory distress syndrome. Annals of Translational Medicine (ATM). 22 September 2019, http://dx.doi.org/10.1136/ annrheumdis-2019-216059

Yeo JG, Wasser M, Kumar P, Lu Pan, Poh,SL, Ally,F Arkachaisri T, Lim A, Yao LJ, Li Yun, Kee Thai Yeo, Lee ESC, Loshinidevi, Chua C, Larbi A, Nyunt MSZ, Ng TP, Chiesa S, Gattorno M, Alberto Martini A, Paleja B, Dutertre CA, Chen J, Yaung KN, Tang PS, SK, Yung CF, Yun A, Tan J, Lee SY, Ginhoux F, Albani S .  Extended Poly-dimensional Immunome Characterisation (EPIC): A Web-based, Reference and Discovery Atlas of the Human Immunome from Neonate to Elderly Nat Biotechnology. In print