Dr. Hong-Wen Tang obtained his B.S. from National Tsing Hua University and received M.S. and Ph.D. from the Institute of Biochemistry at National Taiwan University. After mandatory military service, he accepted a position as a postdoctoral fellow in Dr. Norbert Perrimon’s laboratory in the Department of Genetics at Harvard Medical School. He subsequently joined Duke-NUS Medical School as a Principal Investigator.
Dr Tang’s lab scientific focus is to understand how signaling networks rewire RNA metabolism to alter physiological functions during the process of aging and tumorigenesis. His lab utilizes unique cross-species approach using the Drosophila, mouse and mammalian cells as model systems, coupled with interdisciplinary approach incorporating genetics, biochemistry, cell biology and systems biology, to identify new evolutionary conserved mechanisms underlying human diseases. His lab aims to contribute insights towards the biology of aging as well as tumorigenesis, and provide new therapeutic strategies targeting cancer and mitigating the effects of aging.
Dr Tang’s laboratory mainly focuses on:
• Regulation of transcriptome and RNA epitranscriptome by oncogenic signaling networks
• Regulation of transcriptome and RNA epitranscriptome during aging
• Exploring the role of autophagy during aging and tumorigenesis
• Characterizing the impact of aging and cancer cachexia on stem cell self-renewal and differentiation
https://thwrnalab.wixsite.com/labofrnametabolism
1. Guang-Chao Chen, Janice Y Lee, Hong-Wen Tang, Jayanta Debnath, Sheila M Thomas, Jeffrey Settleman. Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation. Autophagy. Jan 2008; 4 (1), 37-45.
2. Hong‐Wen Tang, Yu‐Bao Wang, Shiu‐Lan Wang, Mei‐Hsuan Wu, Shu‐Yu Lin, Guang‐Chao Chen. Atg1‐mediated myosin II activation regulates autophagosome formation during starvation‐induced autophagy. The EMBO journal. Dec 2011; 30 (4), 636-651
3. Hong-Wen Tang, Guang-Chao Chen. Unraveling the role of myosin in forming autophagosomes. Autophagy. July 2011; 7 (7), 778-779
4. Shih-Fen Chen, Ming-Lun Kang, Yi-Chun Chen, Hong-Wen Tang (co-first author), Cheng-Wen Huang, Wan-Hua Li, Chun-Pu Lin, Chao-Yung Wang, Pei-Yu Wang, Guang-Chao Chen, Horng-Dar Wang. Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila. Journal of Biomedical Science. Dec 2012; 19 (1), 52
5. Ying-Che Chang, Hong-Wen Tang, Suh-Yuen Liang, Tsung-Hsien Pu, Tzu-Ching Meng, Kay-Hooi Khoo, Guang-Chao Chen. Evaluation of Drosophila Metabolic Labeling Strategies for in Vivo Quantitative Proteomic Analyses with Applications to Early Pupa Formation and Amino Acid Starvation. Journal of Proteome Research. Apr 2013, 12 (5), 2138-2150
6. Hong-Wen Tang, Hsiao-Man Liao, Wen-Hsin Peng, Hong-Ru Lin, Chun-Hong Chen, Guang-Chao Chen. Developmental Cell. Dec 2013, 27 (5), 489-503. Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction.
7. Jian Guo, Hong-Wen Tang, Jing Li, Norbert Perrimon, Dong Yan. Xio is a component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex. Proceedings of the National Academy of Sciences. Apr 2018, 115 (14), 3674-3679
8. Hong-Wen Tang# (Co-corresponding author), Yanhui Hu, Chiao-Lin Chen, Baolong Xia, Jonathan Zirin, Min Yuan, John M Asara, Leonard Rabinow, Norbert Perrimon. The TORC1-regulated CPA complex rewires an RNA processing network to drive autophagy and metabolic reprogramming. Cell Metabolism. May 2018, 27 (5), 1040-1054. e8)
9. Chiwei Xu, Hong-Wen Tang, Ruei-Jiun Hung, Yanhui Hu, Xiaochun Ni, Benjamin E Housden, Norbert Perrimon. The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling. Cell Reports. Jan 2019, 26 (3), 670-688. e6
10. Wei Song, Serkan Kir, Shangyu Hong, Yanhui Hu, Xiaohui Wang, Richard Binari, Hong-Wen Tang, Verena Chung, Alexander S Banks, Bruce Spiegelman, Norbert Perrimon. Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation. Developmental Cell. Jan 2019, 48 (2), 277-286. e6
11. Chiwei Xu, Brian Franklin, Hong-Wen Tang, Yannik Regimbald-Dumas, Yanhui Hu, Justine Ramos, Justin A. Bosch, Christians Villalta, Xi He, and Norbert Perrimon. An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. Proceedings of the National Academy of Sciences. January 7, 2020 117 (1) 464-471
12. Lei Gu, Longfei Wang, Hao Chen, Jiaxu Hong, Zhangfei Shen, Abhinav Dhall, Taotao Lao, Chaozhong Liu, Zheng Wang, Yifan Xu, Hong-Wen Tang, Damayanti Chakraborty, Jiekai Chen, Zhihua Liu, Dragana Rogulja, Norbert Perrimon, Hao Wu, Yang Shi. CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila. Cell Discovery volume 6, Article number: 44 (2020)
13. Anjali Bajpai, Quazi Taushif Ahmad, Hong-Wen Tang, Nishat Manzar, Virender Singh, Ashwani Thakur, Bushra Ateeq, Norbert Perrimon, Pradip Sinha. A Drosophila model of oral peptide therapeutics for adult Intestinal Stem Cell tumors. Disease Models & Mechanisms 2020
14. Wenjun Wang, Jianshuang Li, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, Alexei G Basnakian, Hong-Wen Tang, Norbert Perrimon, Qinghua Zhou. Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nature Communications 12 (1), 1-15, 2021.
15. Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, Shu-Yu Lin, Wen-Hsin Li, Hsiang-Jung Hsiao, Ruei-Liang Yan, Hong-Wen Tang, Zhao-Qing Shen, Guang-Chao Chen, Kuen-Phon Wu, Ting-Fen Tsai, Ruey-Hwa Chen. VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism. Nature Communications 12, 1322 (2021).
16. Hong-Wen Tang# (Co-corresponding author), Jui-Hsia Weng, Wen Xing Lee, Yanhui Hu, Lei Gu, Sungyun Cho, Gina Lee, Richard Binari, Cathleen Li, Min En Cheng, Ah-Ram Kim, Jun Xu, Zhangfei Shen, Chiwei Xu, John M. Asara, John Blenis, and Norbert Perrimon. mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy. Proceedings of the National Academy of Sciences. 2021 Mar 9;118(10):e2021945118
17. Sungyun Cho, Gina Lee, Brian F. Pickering, Cholsoon Jang, Jin Park, Long He, Lavina Mathur, Seung-Soo Kim, Sunhee Jung, Hong-Wen Tang, Sebastien Monette, Joshua D. Rabinowitz, Norbert Perrimon, Samie R. Jaffrey, John Blenis. mTORC1 promotes cell growth via m6A-dependent mRNA degradation. Molecular Cell. 2021. In Press.