Directory

Directory

Tang Hung-Wen

Assistant Professor, Signature Research Programme in Cancer & Stem Cell Biology

hongwen.tang@duke-nus.edu.sg

66016482

About

Professional

Research Interests

Teaching

Publications

Bio

Dr. Hong-Wen Tang obtained his B.S. from National Tsing Hua University and received M.S. and Ph.D. from the Institute of Biochemistry at National Taiwan University. After mandatory military service, he accepted a position as a postdoctoral fellow in Dr. Norbert Perrimon’s laboratory in the Department of Genetics at Harvard Medical School. He subsequently joined Duke-NUS Medical School as a Principal Investigator.

Education

Doctor of Philosophy

National Taiwan Univ, Taiwan

Master of Science

National Taiwan Univ, Taiwan

Bachelor of Science

National Tsing Hua Univ, Taiwan, Taiwan

Professional Appointment(s)

Postdoctoral Fellow

Harvard Medical School, Department of Genetics, 10/2014 - 07/2020

Membership

Executive Committee Member

Society of Developmental Biologists Singapore (SDBS), Currently Active

Member

Stem Cell Society Singapore (SCSS), Currently Active

Member

FlyBase Community Advisory Group, Currently Active

Full Member

Sigma Xi, Currently Active

Review Editorial Board

Frontiers in Oncology, Currently Active

Editorial Board

Frontiers in Genetics, Currently Active

Topical Advisory Panel Member

International Journal of Molecular Sciences, Currently Active

Member

Human Frontier Science Program, 2015 - 2018

Research Interests

Our scientific focus is to understand how oncogenic signaling pathways rewire metabolisms during the process of aging and tumorigenesis. Specifically, we will

1. Investigate the regulatory mechanisms underlying tumorigenesis and how advanced tumors induce muscle wasting, also known as cancer cachexia.

2. Characterize the impact of aging on muscles and identify the potential targets for sarcopenia, the aging-induced muscle wasting.

OUR LABORATORY

https://thwrnalab.wixsite.com/labofrnametabolism

Teaching

1. Foundations of Patient Care 1 (FPC1) Course

2. BL5220, 2023/2024– ADVANCED ANIMAL DEVELOPMENT

3. CDM5101 Fundamentals of Cancer Biology Lecture - AY25/26

4. GMS6920 Metabolic Basis of Disease - AY25/26 - Amino Acid Metabolism / Interorgan Communication in Metabolic Diseases

Publications

MESH1-mediated Coenzyme A degradation drives ferroptosis sensitivity and myopathy.

Journal of Clinical Investigation – Lin, C.C., Rose, J., Mestre, A. A., Ding, C.K. C., Chen, S.Y., Choy, S. M., Goh, K. Y., Jiang, W., Lee, W.X., Jiang, Q., Chen, Y., Sun, T., Wu, J., Chen, Y., Oh, Y., Jeong, P., Hong, J., Chua, K., Fitzgerald, M. C., Zhang, G.F., Tang, H.W.*, Zhou, P.,* & Chi, J.T*. (2026)

Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.

Nature Communications – Goh, K.Y., Lee, W.X., Gou, Q., Choy, S.M., Ong, S.C., Gopal Krishnan, P.D., Wang, H., Turqueza, L.R.R., Tan, Q.H., Chua, K., Li, S., Nishiyama, J., Harmston, N., Tang, H.W.* (2026)

Targeting the COX-2/PGE₂ axis to enhance NK and T cell immunotherapy in brain tumors.

Cancer Immunology, Immunotherapy – Shen, C.J., Florentino-Krasnov, J., Liao, Y.C., Tang, H.W., Nainggolan, B. W. M., Chiang, Y.H., & Hsu, T.I. (2026)

Isolation and Biophysical Characterization of Extracellular Vesicles Released by Myocytes.

Bio-protocol – Goh Kah Yong, Lee Wen Xing, Tang Hong-Wen* (2026)

Fine-Tuning Autophagy in Skeletal Muscle: From Homeostasis to Muscle Wasting Disorders.

Aging and disease – Gou Qian; Ong Shi Chee; Lee Wen Xing; Gopal Krishnan Priya D; Tang Hong-Wen* (2026)

DOI

Influenza A virus derived NS1 enhances translation of HPLC purified mRNA and interferon adjuvanted mRNA vaccination.

Scientific reports – Phua Kyle K L; Liu Yi; Zhang Wei; Chin Jas-Min; Tang Hong-Wen; Pardi Norbert; Nair Smita K (2026)

16 (1);

DOI

DEAF1 - a transcriptional brake on muscle autophagy.

Autophagy – Lee Wen Xing; Goh Kah Yong; Choy Sze Mun; Tang Hong-Wen* (2025)

22 (3); 640-641

DOI

Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging.

Proceedings of the National Academy of Sciences of the United States of America – Choy Sze Mun; Goh Kah Yong; Lee Wen Xing; Jiang Weiyi; Gou Qian; Gopal Krishnan Priya D; Chee Ong Shi; Chua Kenon; Harmston Nathan; Tang Hong-Wen* (2025)

122 (48);

DOI View More Info

Functional profiling and visualization of the sphingolipid metabolic network in vivo.

EMBO reports – Tzou Fei-Yang; Hong Cheng-Li; Chen Kai-Hung; Vaughen John P; Lin Wan-Syuan; Hsu Chia-Heng; Rivas-Serna Irma Magaly; Hsu Kai-Yi; Ho Shuk-Man; Panganiban Michael Raphael; Hsieh Hsin-Ti; Li Yi-Jhan; Hsiao Yi; Yeh Hsin-Chun; Yu Cheng-Yu; Tang Hong-Wen; Chou Ya-Hui; Wu Chia-Lin; Lo Chung-Chuan; Mazurak Vera C; Clandinin M Thomas; Huang Shu-Yi; Chan Chih-Chiang (2025)

26 (24); 6380-6417

DOI

Transcriptional regulation of autophagy in skeletal muscle stem cells.

Disease models & mechanisms – Gopal Krishnan Priya D; Lee Wen Xing; Goh Kah Yong; Choy Sze Mun; Turqueza Lewin Raymarc Roldan; Lim Zhuo Han; Tang Hong-Wen* (2025)

18 (2);

DOI

Mitochondrial transfer mediates endothelial cell engraftment through mitophagy.

Nature – Lin Ruei-Zeng; Im Gwang-Bum; Luo Allen Chilun; Zhu Yonglin; Hong Xuechong; Neumeyer Joseph; Tang Hong-Wen; Perrimon Norbert; Melero-Martin Juan M (2024)

629 (8012); 660-668

DOI

FOXO-regulated DEAF1 controls muscle regeneration through autophagy.

Autophagy – Goh Kah Yong; Lee Wen Xing; Choy Sze Mun; Priyadarshini Gopal Krishnan; Chua Kenon; Tan Qian Hui; Low Shin Yi; Chin Hui San; Wong Chee Seng; Huang Shu-Yi; Fu Nai Yang; Nishiyama Jun; Harmston Nathan; Tang Hong-Wen* (2024)

20 (12); 2632-2654

DOI

Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.

Nature Communications – Wang Wenjun; Tan Junyang; Liu Xiaomin; Guo Wenqi; Li Mengmeng; Liu Xinjie; Liu Yanyan; Dai Wenyu; Hu Liubing; Wang Yimin; Lu Qiuxia; Lee Wen Xing; Tang Hong-Wen; Zhou Qinghua (2023)

14 (1);

DOI

A phosphate-sensing organelle regulates phosphate and tissue homeostasis.

Nature – Xu Chiwei; Xu Jun; Tang Hong-Wen; Ericsson Maria; Weng Jui-Hsia; DiRusso Jonathan; Hu Yanhui; Ma Wenzhe; Asara John M; Perrimon Norbert (2023)

617 (7962); 798-806

DOI

Next-generation large-scale binary protein interaction network for Drosophila melanogaster.

Nature Communications – Tang Hong-Wen; Spirohn Kerstin; Hu Yanhui; Hao Tong; Kovács István A; Gao Yue; Binari Richard; Yang-Zhou Donghui; Wan Kenneth H; Bader Joel S; Balcha Dawit; Bian Wenting; Booth Benjamin W; Coté Atina G; de Rouck Steffi; Desbuleux Alice; Goh Kah Yong; Kim Dae-Kyum; Knapp Jennifer J; Lee Wen Xing; Lemmens Irma; Li Cathleen; Li Mian; Li Roujia; Lim Hyobin Julianne; Liu Yifang; Luck Katja; Markey Dylan; Pollis Carl; Rangarajan Sudharshan; Rodiger Jonathan; Schlabach Sadie; Shen Yun; Sheykhkarimli Dayag; TeeKing Bridget; Roth Frederick P; Tavernier Jan; Calderwood Michael A; Hill David E; Celniker Susan E; Vidal Marc; Perrimon Norbert; Mohr Stephanie E (2023)

14 (1);

DOI

A Novel TP53 Gene Mutation Sustains Non-Small Cell Lung Cancer through Mitophagy.

Cells – Wang Yuanli; Goh Kah Yong; Chen Zhencheng; Lee Wen Xing; Choy Sze Mun; Fong Jia Xin; Wong Yun Ka; Li Dongxia; Hu Fangrong; Tang Hong-Wen* (2022)

11 (22);

DOI

The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases.

International Journal of Molecular Sciences – Han Xujun; Goh Kah Yong; Lee Wen Xing; Choy Sze Mun; Tang Hong-Wen* (2022)

24 (1);

DOI

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.

Nature Communications – Wang Wenjun; Li Jianshuang; Tan Junyang; Wang Miaomiao; Yang Jing; Zhang Zhi-Min; Li Chuanzhou; Basnakian Alexei G; Tang Hong-Wen; Perrimon Norbert; Zhou Qinghua (2021)

12 (1);

DOI

mTORC1-chaperonin CCT signaling regulates mA RNA methylation to suppress autophagy.

Proceedings of the National Academy of Sciences of the United States of America – Tang Hong-Wen; Weng Jui-Hsia; Lee Wen Xing; Hu Yanhui; Gu Lei; Cho Sungyun; Lee Gina; Binari Richard; Li Cathleen; Cheng Min En; Kim Ah-Ram; Xu Jun; Shen Zhangfei; Xu Chiwei; Asara John M; Blenis John; Perrimon Norbert (2021)

118 (10);

DOI

mTORC1 promotes cell growth via mA-dependent mRNA degradation.

Molecular Cell – Cho Sungyun; Lee Gina; Pickering Brian F; Jang Cholsoon; Park Jin H; He Long; Mathur Lavina; Kim Seung-Soo; Jung Sunhee; Tang Hong-Wen; Monette Sebastien; Rabinowitz Joshua D; Perrimon Norbert; Jaffrey Samie R; Blenis John (2021)

81 (10); 2064-2075.e8

DOI

Directory

Bio

Education

Doctor of Philosophy

Master of Science

Bachelor of Science

Professional Appointment(s)

Postdoctoral Fellow

Membership

Executive Committee Member

Member

Member

Full Member

Review Editorial Board

Editorial Board

Topical Advisory Panel Member

Member

Research Interests

Teaching

Publications

MESH1-mediated Coenzyme A degradation drives ferroptosis sensitivity and myopathy.

Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.

Targeting the COX-2/PGE₂ axis to enhance NK and T cell immunotherapy in brain tumors.

Isolation and Biophysical Characterization of Extracellular Vesicles Released by Myocytes.

Fine-Tuning Autophagy in Skeletal Muscle: From Homeostasis to Muscle Wasting Disorders.

Influenza A virus derived NS1 enhances translation of HPLC purified mRNA and interferon adjuvanted mRNA vaccination.

DEAF1 - a transcriptional brake on muscle autophagy.

Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging.

Functional profiling and visualization of the sphingolipid metabolic network in vivo.

Transcriptional regulation of autophagy in skeletal muscle stem cells.

Mitochondrial transfer mediates endothelial cell engraftment through mitophagy.

FOXO-regulated DEAF1 controls muscle regeneration through autophagy.

Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.

A phosphate-sensing organelle regulates phosphate and tissue homeostasis.

Next-generation large-scale binary protein interaction network for Drosophila melanogaster.

A Novel TP53 Gene Mutation Sustains Non-Small Cell Lung Cancer through Mitophagy.

The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases.

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.

mTORC1-chaperonin CCT signaling regulates mA RNA methylation to suppress autophagy.

mTORC1 promotes cell growth via mA-dependent mRNA degradation.

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