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Teo Wan Yee

Assistant Professor

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Bio Research Publications

Dr. Wan-Yee Teo, a clinician-scientist, is Head and Principal Investigator of the Pediatric Brain Tumor Research Office at SingHealth Duke-NUS Academic Medical Center, Singapore. Her group conducts their laboratory research at the Humphrey Oei Institute of Cancer Research, National Cancer Center Singapore. The research focus of her group is in the brain tumor microenvironment, particularly in pediatric brain tumors, and translating research findings in tumor biology, genomics and preclinical testing to bedside benefits for children with brain tumors. She completed her clinical training in Pediatrics and Pediatric NeuroOncology in the USA, and is board certified with the American Board of Pediatrics, and the Royal College of Pediatrics and Child Health in the UK. Her research training was completed in the Cancer Genomics Program at Baylor College of Medicine, USA. Her research combines genomic methodologies and mouse models to study the complex regulation in the developmental biology of brain tumors. An area of emphasis is the preclinical development of therapeutics for brain tumors using patient-derived orthotopic brain tumor xenograft modelling

Lab Unit of Paediatric Brain Tumour Research Office

EXCERPT FROM PBTRO TEAM MEMBERS & INTERN STUDENTS

“Our work focuses on cell culture and utilises molecular techniques to unravel the cell biology behind the drug effects on brain tumours; this is in line with our team goal to discover effective and novel treatments for the benefit of patients.”

“The most important insight I learnt from this internship was realising the tenacity of character required to become a successful researcher. Their passion for their work, and their grit and perseverance constantly inspire me to work hard in my studies knowing that my study now is not as challenging as the lives of these researchers.”

Education Initiatives

We have embarked on 2 Education Initiatives on SingHealth-Duke-NUS Academic Medical Center, Singapore.

Clinical Professionalism Program @Duke-NUS

Program Lead: Asst Professor Wan-Yee Teo

With a focus on Poster Presentation Skills (Scientific and Clinical Posters), Giving Academic Feedback using DESC Model, Feedback Skills for Junior Doctors, Clinical Teaching Skills for Junior Doctors, Safety and Survival Skills during Residency. This curriculum was developed with Medical Education, Research & Evaluation Department in Practice Course 4, Duke-NUS Medical School. Practice Course 4 has evolved to Clinical Professionalism Program @Duke-NUS. Together with past graduates of Practice Course 4, who are now in their residency/internship at SingHealth, we work towards extending our initiative to selected SingHealth Residency Programs.

Education Material on Safety in Healthcare Research Environments

Program Lead: Asst Professor Wan-Yee Teo

We have developed a short series of education/teaching materials on safety in healthcare research environments for Handling of Sharps, and Basics of IT Security in Healthcare Research Environments. The education slides on Handling of Sharps are being used for workplace safety orientation by National Cancer Center Singapore and SingHealth Experimental Medicine Center, in addition to our laboratory unit at Pediatric Brain Tumor Research Office, SingHealth-Duke-NUS Academic Medical Center.

Selected Peer-reviewed Publications:

Teo WY, Tan HK, Goh BC, Putti TC. Postirradiation sarcoma of the sphenoid bone--a case report. Ann Acad Med Singapore. 2006;35(2):104-7.

Teo WY*, Chan MY, Lam CM, Chong CY. Skin manifestation of Stenotrophomonas maltophilia infection--a case report and review article. Ann Acad Med Singapore. 2006;35(12):897-900.

Chan MY, Teo WY, Seow WT, Tan AM. Epidemiology, management and treatment outcome of medulloblastoma in Singapore.Ann Acad Med Singapore. 2007;36(5):314-8.

Teo WY*, Loh TF, Tan AM. Avoiding dialysis in tumour lysis syndrome: is urate oxidase effective? - a case report and review of literature. Ann Acad Med Singapore. 2007;36(8):679-83.

Teo WY*, Choong CT. Neurological presentations of conversion disorders in a group of Singapore children. Pediatr International. 2008;50(4):533-6.

Teo WY*, Rajadurai VS, Sriram B. Morbidity of a Parainfluenza outbreak among preterm infants in a neonatal unit. Ann Acad Med Singapore. 2010;39:837-42.

Teo WY*, Chan MY, Ng KC, Tan AM. Bony presentations of childhood hematological malignancies in the emergency room. J Pediatr Child Health. 2012;48(4):311-316.

Teo WY*, Tan AM, Chan MY. Langerhan Cell Histiocytosis-A mimicker of tuberculosis of the spine.  J Pediatr Child Health. 2012;48:1103-1106.

Teo WY*, Chintagumpala M, Okcu MF, Dauser RC, Mahajan A, Adesina AM, Whitehead WE, Jea A, Bollo R, Paulino AC. A retrospective analysis of the patterns of failure in pediatric myxopapillary ependymoma. J Radiat Oncol. 2013;2(1):21-26.

Teo WY, JMF Su, Shen JS, Yu A, Wang J, Chow WY, Li XN, Dauser R, Whitehead W, Adesina AM, Chintagumpala M, Man TZ, Lau CC. Implications of tumor locations on subtypes of medulloblastoma. Ped Blood and Cancer. 2013;60(9):1408-10.

Teo WY*, Myseros JM. The gut or the brain? –Gastrointestinal Misdiagnoses of Infantile Brain Tumors. Childs Nerv Syst.  2014;30(8):1449-53.

Teo WY*, Ross J, Bollo RJ, Seow WT, Tan AM, Kang SG, Kim DS, Mohila CA, Li XN, Lau CC, Adesina AM, Su JMF. Atypical location and clinical behavior of non-teratomatous intracranial germ cell tumors in children. Journal of Neurosurgery-Pediatrics. 2014;25:1-8.

Teo WY*, Kim S, Mensah-Bonsu N. The Curious Case of Ileocolic Intussusception. J Pediatr Child Health. 2014;50(7):573-4.

Teo WY*, Dulman RY, Vinh T. Lung Opacification. JAMA. 2014;311(23):2434-5.

Teo WY*, Elghetany MT, Shen J, Man TK, Li XN, Chintagumpala M, Su JMF, Dauser R, Whitehead W, Adesina AM, Lau CC. Therapeutic Implications of CD1d Expression and Tumor-Infiltrating Macrophages in Pediatric Medulloblastomas. Journal of NeuroOncology. 2014;120(2):293-301.

Lindsay H, Huang Y, Du Y, Braun FK, Teo WY, Kogiso M, Qi L, Zhang H, Zhao S, Mao H, Lin F, Baxter P, Su JM, Terashima K, Perlaky L, Chintagumpala M, Adesina A, Lau CC, Parsons DW, Li XN. Preservation of KIT genotype in a novel pair of patient derived orthotopic xenograft mouse models of metastatic pediatric CNS germinoma. Journal of NeuroOncology. 2016;128(1):47-56.

Teo WY*, Karthik S, Pratap SV, Shen J, Chow WY, Lau CC, Yang HK, Park J, Kang SG, Li XN, Nam DH, Hui KM. Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations. Scientific Reports Sci Rep. 2019 May 15;9(1):7442.

Teo WY*, Sekar K, Seshachalam P, Shen J, Chow WY, Lau CC, Yang H, Park J, Kang SG, Li X, Nam DH, Hui KM. Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations. Sci Rep. 2019 May 15;9(1):7442.


Top 100 Most Downloaded Cancer Articles in Scientific Reports in 2019.

Teo WY*, Sriram B, Alim AA, Ruan X, Rajadurai VS. A single-center observational study on congenital diaphragmatic hernia: Outcome, predictors of mortality and experience from a tertiary perinatal center in Singapore. Pediatr Neonatol. 2020 Aug;61(4):385-392.

Qi L, Kogiso M, Du Y, Zhang H, Braun FK, Huang Y, Teo WY, Lindsay H, Zhao S, Baxter P, Zhao X, Yu L, Liu Z, Zhang X, Su JM, Adesina A, Yang J, Chintagumpala M, Perlaky L, Tsz-Kwong Man C, Lau CC, Li XN. Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors. Cancer Lett. 2020 Sep 3:S0304-3835(20)30449-3. doi: 10.1016/j.canlet.2020.08.035. Online ahead of print.

Teo WY*. Implications for border containment strategies when COVID-19 presents atypically. Public Health. 2020 Jul 24;186:193-196. doi: 10.1016/j.puhe.2020.07.019. Online ahead of print.

Yoon SJ, Son HY, Shim JK, Moon JH, Kim EH, Chang JH, Teo WY, Kim SH, Park SW, Huh YM, Kang SG. Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres. J Transl Med. 2020 Dec 14;18(1):482. doi: 10.1186/s12967-020-02647-8.

Elghetany MT, Ho JM, Shi-Qi LH, Karthik S, Su JMF, Lin Q, Du Y, Shen J, Chow WY, Lau CC, Adesina A, Major A, Erdreich-Epstein A, Hui KM, Li XN, Teo WY*. Maximizing the potential of aggressive mouse tumor models in preclinical drug testing. Scientific Reports 2021 Jun 2;11(1):11580. doi: 10.1038/s41598-021-91167-6.

*Corresponding Author