Directory

Open Fund - Young Individual Research Grant (OF-YIRG)

National Medical Research Council,2024

Khoo Postdoctoral Fellowship Award

Duke-NUS Medical School,2019

Interest in epidermal barrier maintenance and mechanisms that contribute to human skin diseases

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.

The Journal of biological chemistry – Wong Bernice H; Chan Jia Pei; Cazenave-Gassiot Amaury; Poh Rebecca W; Foo Juat Chin; Galam Dwight L A; Ghosh Sujoy; Nguyen Long N; Barathi Veluchamy A; Yeo Sia W; Luu Chi D; Wenk Markus R; Silver David L (2016)

291 (20); 10501-14

The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain.

PLoS biology – Chan Jia Pei*; Wong Bernice H*; Chin Cheen Fei; Galam Dwight L A; Foo Juat Chin; Wong Loo Chin; Ghosh Sujoy; Wenk Markus R; Cazenave-Gassiot Amaury; Silver David L *Co-first author. (2018)

16 (8);

The lipid transporter Mfsd2a maintains pulmonary surfactant homeostasis.

The Journal of biological chemistry – Wong Bernice H; Mei Ding; Chua Geok Lin; Galam Dwight L; Wenk Markus R; Torta Federico; Silver David L (2022)

298 (3);

Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination.

Neurogenetics – Harel Tamar; Quek Debra Q Y; Wong Bernice H; Cazenave-Gassiot Amaury; Wenk Markus R; Fan Hao; Berger Itai; Shmueli Dorit; Shaag Avraham; Silver David L; Elpeleg Orly; Edvardson Shimon (2018)

19 (4); 227-235

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome.

Nature genetics – Guemez-Gamboa Alicia; Nguyen Long N; Yang Hongbo; Zaki Maha S; Kara Majdi; Ben-Omran Tawfeg; Akizu Naiara; Rosti Rasim Ozgur; Rosti Basak; Scott Eric; Schroth Jana; Copeland Brett; Vaux Keith K; Cazenave-Gassiot Amaury; Quek Debra Q Y; Wong Bernice H; Tan Bryan C; Wenk Markus R; Gunel Murat; Gabriel Stacey; Chi Neil C; Silver David L; Gleeson Joseph G (2015)

47 (7); 809-13

The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8 Memory T Cell Maintenance and Secondary Response to Infection.

Journal of immunology (Baltimore, Md. : 1950) – Piccirillo Ann R; Hyzny Eric J; Beppu Lisa Y; Menk Ashley V; Wallace Callen T; Hawse William F; Buechel Heather M; Wong Bernice H; Foo Juat Chin; Cazenave-Gassiot Amaury; Wenk Markus R; Delgoffe Greg M; Watkins Simon C; Silver David L; D'Cruz Louise M (2019)

203 (1); 117-126

Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport.

Proceedings of the National Academy of Sciences of the United States of America – Chua Geok-Lin; Tan Bryan C; Loke Randy Y J; He Menglan; Chin Cheen-Fei; Wong Bernice H; Kuk Alvin C Y; Ding Mei; Wenk Markus R; Guan Lan; Torta Federico; Silver David L (2023)

120 (10);

Structural basis of omega-3 fatty acid transport across the blood-brain barrier.

Nature – Cater Rosemary J; Chua Geok Lin; Erramilli Satchal K; Keener James E; Choy Brendon C; Tokarz Piotr; Chin Cheen Fei; Quek Debra Q Y; Kloss Brian; Pepe Joseph G; Parisi Giacomo; Wong Bernice H; Clarke Oliver B; Marty Michael T; Kossiakoff Anthony A; Khelashvili George; Silver David L; Mancia Filippo (2021)

595 (7866); 315-319

Deficiency in the omega-3 lysolipid transporter Mfsd2a leads to aberrant oligodendrocyte lineage development and hypomyelination.

The Journal of clinical investigation – Sengottuvel Vetrivel; Hota Monalisa; Oh Jeongah; Galam Dwight L; Wong Bernice H; Wenk Markus R; Ghosh Sujoy; Torta Federico; Silver David L (2023)

133 (12);

Blood-derived lysophospholipid sustains hepatic phospholipids and fat storage necessary for hepatoprotection in overnutrition.

The Journal of clinical investigation – Chin Cheen Fei; Galam Dwight LA; Gao Liang; Tan Bryan C; Wong Bernice H; Chua Geok-Lin; Loke Randy Yj; Lim Yen Ching; Wenk Markus R; Lim Miao-Shan; Leow Wei-Qiang; Goh George Bb; Torta Federico; Silver David L (2023)

133 (17);

Mfsd2a-mediated lysolipid transport is important for renal recovery after acute kidney injury.

Journal of lipid research – Loke Randy Y J; Chin Cheen Fei; Liang Gao; Wong Bernice H; Galam Dwight L A; Tan Bryan C; Chua Geok-Lin; Minegishi Shintaro; Morisawa Norihiko; Sidorov Iulia; Heijs Bram; Titze Jens; Wenk Markus R; Torta Federico; Silver David L (2023)

64 (8);

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma.

Cancer cell – Ooi Aikseng; Wong Jing-Chii; Petillo David; Roossien Douglas; Perrier-Trudova Victoria; Whitten Douglas; Bernice Wong Huimin; Tan Min-Han; Zhang Zhongfa; Yang Ximing J; Zhou Ming; Gardie Betty; Molinié Vincent; Richard Stéphane; Tan Puay Hoon; Teh Bin Tean; Furge Kyle A (2011)

20 (4); 511-23

Exome sequencing of liver fluke-associated cholangiocarcinoma.

Nature genetics – Ong Choon Kiat; Subimerb Chutima; Pairojkul Chawalit; Wongkham Sopit; Cutcutache Ioana; Yu Willie; McPherson John R; Allen George E; Ng Cedric Chuan Young; Wong Bernice Huimin; Myint Swe Swe; Rajasegaran Vikneswari; Heng Hong Lee; Gan Anna; Zang Zhi Jiang; Wu Yingting; Wu Jeanie; Lee Ming Hui; Huang DaChuan; Ong Pauline; Chan-on Waraporn; Cao Yun; Qian Chao-Nan; Lim Kiat Hon; Ooi Aikseng; Dykema Karl; Furge Kyle; Kukongviriyapan Veerapol; Sripa Banchob; Wongkham Chaisiri; Yongvanit Puangrat; Futreal P Andrew; Bhudhisawasdi Vajarabhongsa; Rozen Steve; Tan Patrick; Teh Bin Tean (2012)

44 (6); 690-3

Methylation subtypes and large-scale epigenetic alterations in gastric cancer.

Science translational medicine – Zouridis Hermioni; Deng Niantao; Ivanova Tatiana; Zhu Yansong; Wong Bernice; Huang Dan; Wu Yong Hui; Wu Yingting; Tan Iain Beehuat; Liem Natalia; Gopalakrishnan Veena; Luo Qin; Wu Jeanie; Lee Minghui; Yong Wei Peng; Goh Liang Kee; Teh Bin Tean; Rozen Steve; Tan Patrick (2012)

4 (156);