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My team studies the human neural bases of cognitive functions and the associated vulnerability patterns in aging and neuropsychiatric disorders using multimodal neuroimaging and psychophysical techniques. We are interested in the large-scale brain structural and functional networks in healthy developing and aging brain and symptoms-related changes in diseases such as neurodegenerative disorders and psychosis. Statistical, computational, and machine learning methods are developed to analyze and fuse multimodal neuroimaging data. By integrating longitudinal behavior, neuroimaging, and genotype data, our long-term goal is to investigate the interactions among brain network dynamics, behavior, diseases, and genotypes to develop non-invasive biomarkers for early detection, differential diagnosis, progression monitoring, and treatment design. The current research interests in her lab include: • Detect early brain network changes in preclinical and clinical neuropsychiatric disorders such as Alzheimer’s disease and psychosis • Understand the neurophysiological signatures and behavioral relevance of time-varying brain functional connectivity • Examine the longitudinal brain network changes and its associations with cognitive and mental problems in the developing and ageing brain • Investigate the underlying neural mechanism of brain-computer interface-based intervention • Examine the influence of amyloid-beta, tau, and cerebrovascular pathology on brain functional and structural connectivity changes in ageing • Develop machine learning and statistical methods for big data analysis, brain decoding, brain-behavior associations, and disease prognosis 

Website: www.neuroimaginglab.org Twitter: @MNNDL_lab

Associations of blood cardiovascular biomarkers with brain free water and its relationship to cognitive decline: A diffusion-MRI study

Neurology – 1. Ji F, Chai YL, Liu S, … Lai MKP*, Zhou JH (2023)

101 (2); 151-163

Variations in cortical functional gradients relate to dimensions of psychopathology in preschool children

Journal of the American Academy of Child and Adolescent Psychiatry – Nguyen TT, Qian X, Ng KK, … Zhou JH (2023)

63 (1); 80-89

Brain white matter extracellular free-water increases are related to reduced neurocognitive function in systemic lupus erythematosus

Rheumatology – Qian X, Ji F, Ng, KK, Koh, AK, Loo BRY, Townsend MC, Pasternak O, Tay SH, Zhou JH, Mak A (2022)

61 (3); 1166-1174

Stage-dependent differential influence of metabolic and structural networks on memory across Alzheimer’s disease continuum

eLife – Ng KP*, Qian X*, Ng KK, Ji F, Rosa-Neto P, Gauthier S, Kandiah N, Zhou JH (2022)

11

Distinct network topology in Alzheimer's disease and behavioral variant frontotemporal dementia

Alzheimers Res Ther – Ng ASL, Wang J, Ng KK, Chong JSX, Qian X, Lim JKW, Tan YJ, Yong ACW, Chander RJ, Hameed S, Ting SKS, Kandiah N, Zhou JH (2021)

13 (1);

Amyloid and cerebrovascular burden divergently influence brain functional network changes over time

Neurology – Chong JSX*, Jang H*, Kim HJ, Ng KK, Na DL, Lee JH, Seo SW*, Zhou JH (2019)

93 (16); 1514-1525

Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder

Translational Psychiatry – Qian X, Loo BRY, Castellanos FX, Liu SW, Koh HL, Poh WXW, Krishnan R, Fung D, Chee MWL, Guan CT, Lee TS, Lim CG*, Zhou J (2018)

8 (1);

Carrying the past to the future: Distinct brain networks underlie individual differences in human spatial working memory capacity.

NeuroImage – Liu S; Poh JH; Koh HL; Ng KK; Loke YM; Lim JKW; Chong JSX; Zhou J (2018)

176 1-10

Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer’s disease.

Brain – Chong JSX; Liu SW; Loke YM; Hilal S; Ikram MK; Y Xu; Tan BY; Venketasubramanian N; Chen CLH; Zhou J (2017)

140 (11); 3012-3022 (Editor's choice)

Progression from selective to general involvement of hippocampal subfields in schizophrenia.

Molecular Psychiatry – Ho NF; Iglesias JE; Sum MY; Kuswanto CN; Sitoh YY; De Souza J; Hong Z; Fischl B; Roffman JL; Zhou J*; Sim K*; Holt DJ* (*Joint senior) (2017)

22 (1); 142-152

Large-scale network topology reveals heterogeneity in individuals with at risk mental state for psychosis: findings from the longitudinal youth-at-risk study.

Cerebral Cortex – Wang C; Lee J; Ho NF; Lim KWJ; Poh JS; Rekhi G; Krishnan R; Keefe RSE; Adcock RA; Wood SJ; Fornito A; Chee MWL; Zhou J (2017)

Oct 27 1-10

Hemispheric lateralization abnormalities of the white matter microstructure in patients with schizophrenia and bipolar disorder.

Journal of Psychiatry and Neuroscience – Ho NF*; Li Z*; Ji F; Wang M; Kuswanto CN; Sum MY; Tng HY; Sitoh YY; Sim K; Zhou J (2017)

42 (4); 242-251

Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in AD with and without cerebrovascular disease.

Alzheimer’s Research and Therapy – Ji F; Pasternak O; Liu SW; Choo BL; Hilal S; Xu X; Ikram K; Venketasubramanian N; Chen CLH; Zhou J (2017)

17 9-63

Reduced functional segregation between the default mode network and the executive control network in healthy older adults: A longitudinal study.

NeuroImage – Ng KK; Lo JC; Lim JKW; Chee MWL; Zhou J (2016)

133 321-330

Spontaneous eyelid closures link vigilance fluctuation with fMRI dynamic connectivity states.

Proceedings of the National Academy of Sciences of the United States of America – Wang C; Ong JL; Patanaik A; Zhou J*; Chee MWL* (Joint senior) (2016)

113 (34); 9653-8

Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study.

Psychological Medicine – Wang C; Ji F; Hong Z; Poh J S; Krishnan R; Lee J; Rekhi G; Keefe R S E; Adcock R A; Wood S J; Fornito A; Pasternak O; Chee M W L; Zhou J (2016)

46 (13); 2771-83

Lack of evidence for regional brain volume or cortical thickness abnormalities in youths at clinical high risk for psychosis: Findings from the longitudinal youth at risk study.

Schizophrenia Bulletin – Klauser P; Zhou J*; Lim JK; Poh JS; Zheng H; Tng HY; Krishnan R; Lee J; Keefe RS; Adcock RA; Wood SJ; Fornito A; Chee MWL (* corresponding and joint first) (2015)

41 (6); 1285-1293

Differential age-dependent associations of gray matter volume and white matter integrity with processing speed in healthy older adults.

NeuroImage – Hong Z; Ng KK; Sim SKY; Ngeow MY; Zheng H; Lo JC; Chee MWL; Zhou J (2015)

123 42-50

Network Dysfunction in Alzheimer's Disease and Frontotemporal Dementia: Implications for Psychiatry

Biological Psychiatry – Zhou J, Seeley WW (2014)

75 (7); 565-573

Predicting regional neurodegeneration from the healthy brain functional connectome.

Neuron – Zhou J; Gennatas ED; Kramer JH; Miller BL; Seeley WW (2012)

73 (6); 1216-27 (Cover article)