The human circadian clock: inputs and outputs

Start Date & Time: 
Friday, 8 March, 2013 - 12:00
End Date & Time: 
Friday, 8 March, 2013 - 13:00

Conference Room 4D, level 4
Duke-NUS Graduate Medical School

Speaker Details: 

Asst. Prof. Joshua Gooley with Ivan Ho and Chern-Pin Chua
Chronobiology and Sleep Laboratory


Part 1: Daily rhythms of behavior are driven by a circadian clock in the anterior hypothalamus. Normally, the circadian clock is entrained by exposure to the solar cycle.  In humans, it remains controversial whether rod-cone photoreceptors play a significant role in light regulation of circadian rhythms. We found that exposure to long-wavelength red light can reset circadian rhythms in some individuals, suggesting that classical visual photoreceptors can function as circadian photoreceptors.

Part 2: An important function of the circadian clock is to ensure that metabolic pathways are temporally coordinated with 24-hour cycles of rest-activity and feeding.  Using a lipidomics-based approach, we found substantial inter-individual variation in the timing and strength of lipid rhythms, suggesting that there are different circadian metabolic phenotypes in the general population. These results have potential implications for lipid metabolism disorders linked to circadian clock disruption.   


Prof Michael Chee
Duke-NUS Graduate Medical School
Neuroscience & Behavioral Disorders Program