NBD Invited Speaker Seminar

Start Date & Time: 
Monday, 19 June, 2017 - 14:00
End Date & Time: 
Monday, 19 June, 2017 - 15:00
Venue: 

Meeting Room 7C
Level 7

Speaker: 
Speaker Details: 

Dr Taejoon Kwon
Department of Biomedical Engineering,
School of Life Sciences,
Ulsan National Institute of Science and Technology (UNIST),
Republic of Korea

Studying human disease-related genes using African clawed frog, Xenopus laevis, as a new genomic model system

Synopsis: 

Recently we finished the genome project for African clawed frog, Xenopus laevis, the one of major model organisms in cell and developmental biology. By analyzing almost ten thousands highly conserved duplicated genes, we revealed the functional consequence of duplicated genes during vertebrate development. Large-scale gene dosage imbalance by chromosomal duplication causes many human diseases, including Down syndrome and various types of cancers. Although we have learned about the functional consequences of duplicated genes in several model organisms, such as yeast and plants, there was no proper model system to study their roles in vertebrate development. Here I present the allotetraploid genome of the African clawed frog Xenopus laevis that has maintained two copies of nine homologous (duplicated) chromosomes (2N=18) for over 17 million years. In addition to the insight for the genome duplication, these genomic resources would make Xenopus as an attractive model organism in genomic research to study the function of human disease-associated genes.

Host: 

Asst Prof Shawn Je
Principal Investigator
NBD