ABOUT THIS LECTURE:
Neurostimulation has transformed care for drug-resistant epilepsy, yet most therapies continue to rely on uniform targeting and programming strategies. This “one-size-fits-all” approach contrasts with mounting evidence that epilepsy is an individualised disorder of distributed, dynamic brain networks, with dysfunction extending beyond seizures to cognition, mood, arousal, and sleep being key determinants of quality of life. This talk will present a network-level framework that integrates cortical and subcortical approaches across responsive neurostimulation (RNS) and deep brain stimulation (DBS). Emphasis will be placed on personalisation through electrophysiology- and imaging-guided strategies, leveraging intracranial EEG, chronic neural sensing, and multimodal neuroimaging. Advances in computational modeling and adaptive stimulation will be discussed as tools to inform target selection, stimulation timing, and parameter optimisation across evolving brain states. By aligning therapy with each patient’s unique neurophysiological landscape, network-level stimulation has the potential to offer precise, meaningful outcomes in epilepsy.
HOST:
Dr Joshua J Gooley
Associate Professor
Neuroscience & Behavioural Disorders Programme
Duke-NUS Medical School
VENUE:
Duke-NUS Medical School
Amphitheatre, Level 2
CONTACT PERSON:
Ms Sherlyn Leo (sherlynleo@duke-nus.edu.sg)
Duke-NUS Research Affairs Department
Date and Time
03 Mar 2026 @ 12:00 - 03 Mar 2026 @ 13:00
Speaker
Dr Shruti Agashe
Assistant Professor
Departments of Neurology,
Neurosurgery & Biomedical Engineering
Duke University School of Medicine
Dr. Agashe is a physician–scientist at Duke University whose work integrates biomedical engineering, electrophysiology-based biomarkers and neurotechnology development. She serves as the Vice Chair for Neurotechnology and Neuroethics for the American Epilepsy Society’s 2025 meeting and as Director of Neuromodulation Workshops for the American Clinical Neurophysiology Society from 2024 to 2026. She also serves in editorial roles for Epilepsy Currents and the Journal of Clinical Neurophysiology.