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My commitment to advancing the understanding and treatment of cardiovascular disease has been unwavering. My primary focus is on preventing heart failure by studying the impact of ischemia-reperfusion injury on the heart, with a particular emphasis on improving mitochondrial health and function. The potential of this research to revolutionize the prevention and treatment of heart failure is a beacon of hope in the field of cardiovascular medicine.

For over a decade, I have dedicated my research to testing novel therapies that protect the heart from ischemic conditions. By exploring mitochondrial mechanisms, my work aims to optimize energy production, reduce cellular stress, and enhance the heart's resilience to ischemic events.

My passion is not just a scientific pursuit, but a mission to improve the lives of patients today and shape a healthier future for those yet to be affected. This motivation underpins my current research investigating therapies targeting mitochondrial pathways involved in cell death. Such therapies have the potential to minimize cardiac cell damage during ischemic events and ultimately prevent the onset of heart failure, directly impacting the quality and longevity of patients' lives.

As I continue my journey in this captivating field, I firmly believe that every piece of knowledge we uncover brings us closer to more effective, targeted treatments for heart disease. This conviction inspires me daily and fuels my commitment to breaking new ground in cardiovascular medicine. 

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission.

Cardiovascular research – Kalkhoran Siavash Beikoghli; Kriston-Vizi Janos; Hernandez-Resendiz Sauri; Crespo-Avilan Gustavo E; Rosdah Ayeshah A; Lees Jarmon G; Costa Joana Rodrigues Simoes Da; Ling Naomi X Y; Holien Jessica K; Samangouei Parisa; Chinda Kroekkiat; Yap En Ping; Riquelme Jaime A; Ketteler Robin; Yellon Derek M; Lim Shiang Y; Hausenloy Derek J (2022)

118 (1); 282-294

Targeting mitochondrial shape: at the heart of cardioprotection.

Basic research in cardiology – Hernandez-Resendiz Sauri; Prakash Aishwarya; Loo Sze Jie; Semenzato Martina; Chinda Kroekkiat; Crespo-Avilan Gustavo E; Dam Linh Chi; Lu Shengjie; Scorrano Luca; Hausenloy Derek J (2023)

118 (1);

A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model.

Scientific reports – Schumacher David; Liehn Elisa A; Nilcham Pakhwan; Mayan David Castaño; Rattanasopa Chutima; Anand Kaviya; Crespo-Avilan Gustavo E; Hernandez-Resendiz Sauri; Singaraja Roshni R; Cook Stuart A; Hausenloy Derek J (2021)

11 (1);

Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy.

Autophagy – Tripathi Madhulika; Singh Brijesh Kumar; Liehn Elisa A; Lim Sheau Yng; Tikno Keziah; Castano-Mayan David; Rattanasopa Chutima; Nilcham Pakhwan; Abdul Ghani Siti Aishah Binte; Wu Zihao; Azhar Syaza Hazwany; Zhou Jin; Hernández-Resèndiz Sauri; Crespo-Avilan Gustavo E; Sinha Rohit Anthony; Farah Benjamin Livingston; Moe Kyaw Thu; De Silva Deidre Anne; Angeli Veronique; Singh Manvendra K; Singaraja Roshni R; Hausenloy Derek J; Yen Paul Michael (2022)

18 (9); 2150-2160

Reduction of no-reflow and reperfusion injury with the synthetic 17β-aminoestrogen compound Prolame is associated with PI3K/Akt/eNOS signaling cascade.

Basic research in cardiology – Hernández-Reséndiz Sauri; Palma-Flores Carlos; De Los Santos Sergio; Román-Anguiano Nadia G; Flores Mirthala; de la Peña Aurora; Flores Pedro L; Fernández-G Juan M; Coral-Vázquez Ramón M; Zazueta Cecilia (2015)

110 (2);

Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes.

Cardiovascular research – Ramachandra Chrishan J A; Kp Myu Mai Ja; Chua Jasper; Hernandez-Resendiz Sauri; Liehn Elisa A; Knöll Ralph; Gan Li-Ming; Michaëlsson Erik; Jonsson Malin K B; Ryden-Markinhuhta Katarina; Bhat Ratan V; Fritsche-Danielson Regina; Lin Ying-Hsi; Sadayappan Sakthivel; Tang Hak Chiaw; Wong Philip; Shim Winston; Hausenloy Derek J (2022)

118 (2); 517-530

Impact of Cardioprotective Therapies on the Edema-Based Area at Risk by CMR in Reperfused STEMI.

Journal of the American College of Cardiology – Bulluck Heerajnarain; Chan Mervyn H H; Paradies Valeria; Bryant Jennifer A; Hernández-Reséndiz Sauri; Cabrera-Fuentes Hector A; Watson Timothy J; Chan Mark Y; Tan Jack W; Hausenloy Derek J (2018)

71 (24); 2856-2858

Metabolic reprogramming of immune cells by mitochondrial division inhibitor-1 to prevent post-vascular injury neointimal hyperplasia.

Atherosclerosis – Crespo-Avilan Gustavo E; Hernandez-Resendiz Sauri; Ramachandra Chrishan J; Ungureanu Victor; Lin Ying-Hsi; Lu Shengjie; Bernhagen Jürgen; El Bounkari Omar; Preissner Klaus T; Liehn Elisa A; Hausenloy Derek J (2024)

390

Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance.

Scientific reports – Dongworth Rachel K; Campbell-Washburn Adrienne E; Cabrera-Fuentes Hector A; Bulluck Heerajnarain; Roberts Thomas; Price Anthony N; Hernández-Reséndiz Sauri; Ordidge Roger J; Thomas David L; Yellon Derek M; Lythgoe Mark F; Hausenloy Derek J (2017)

7 (1);

FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.

Arteriosclerosis, thrombosis, and vascular biology – Yakala Gopala K; Cabrera-Fuentes Hector A; Crespo-Avilan Gustavo E; Rattanasopa Chutima; Burlacu Alexandrina; George Benjamin L; Anand Kaviya; Mayan David Castaño; Corlianò Maria; Hernández-Reséndiz Sauri; Wu Zihao; Schwerk Anne M K; Tan Amberlyn L J; Trigueros-Motos Laia; Chèvre Raphael; Chua Tricia; Kleemann Robert; Liehn Elisa A; Hausenloy Derek J; Ghosh Sujoy; Singaraja Roshni R (2019)

39 (3); 387-401

(-)-Epicatechin induces physiological cardiac growth by activation of the PI3K/Akt pathway in mice.

Molecular nutrition & food research – De Los Santos Sergio; García-Pérez Viridiana; Hernández-Reséndiz Sauri; Palma-Flores Carlos; González-Gutiérrez Carlos J; Zazueta Cecilia; Canto Patricia; Coral-Vázquez Ramón M (2017)

61 (2);

Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography.

Physiological reports – Beikoghli Kalkhoran Siavash; Hall Andrew R; White Ian J; Cooper Jackie; Fan Qiao; Ong Sang-Bing; Hernández-Reséndiz Sauri; Cabrera-Fuentes Hector; Chinda Kroekkiat; Chakraborty Bibhas; Dorn Gerald W; Yellon Derek M; Hausenloy Derek J (2017)

5 (17);

IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized controlled multicenter study on the effect of ischemic preconditioning

Cardiovascular Research – Sauri Hernandez-Resendiz1,2*, Reinis Vilskersts3,4*, David Aluja5,6, Ioanna Andreadou7, Péter Bencsik8,9, Maija Dambrova3,4, Panagiotis Efentakis7, Fei Gao2,10, Zoltán Giricz9,11, Javier Inserte5,6, Roisin Kelly-Laubscher12, Attila Kiss13, Thomas Krieg14, Brenda R. Kwak15, Sandrine Lecour16, Gary Lopaschuk17, Michał Mączewski18, Michał Waszkiewicz18, Marta Oknińska18, Pasquale Pagliaro19, Bruno Podesser13, Hiran A. Prag14, Marisol Ruiz-Meana5,6, Tamara Szabados8, Coert J. Zuurbier20, Péter Ferdinandy11**, Derek J. Hausenloy1,2,21,22**  (2024)

PHO-ERK1/2 interaction with mitochondria regulates the permeability transition pore in cardioprotective signaling.

Life sciences – Hernández-Reséndiz Sauri; Zazueta Cecilia (2014)

108 (1); 13-21

Postconditioning protects against reperfusion injury in hypertensive dilated cardiomyopathy by activating MEK/ERK1/2 signaling.

Journal of cardiac failure – Hernández-Reséndiz Sauri; Roldán Francisco-Javier; Correa Francisco; Martínez-Abundis Eduardo; Osorio-Valencia Gabriel; Ruíz-de-Jesús Oscar; Alexánderson-Rosas Erick; Vigueras Rosa M; Franco Martha; Zazueta Cecilia (2013)

19 (2); 135-46

The DJ-1-derived peptide, ND-13 confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway

bioRxiv – Aishwarya Prakash, Gustavo E Crespo-Avilan,  Sze Jie Loo, En Ping Yap, Jasper Chua, Ching Jianhong, Zeng Yitong, Ying-Hsi Lin, Whendy Contreras, Fan Yu, Shuo Cong, Linh Chi Dam, Chrishan J Ramachandra, Siavash Beikoghli Kalkhoran, Shengjie Lu, Daniel Offen, Sauri Hernandez-Resendiz*, Derek J Hausenloy*.                                                                             *Joint senior authors (2024)

Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities.

Pharmacology & therapeutics – Ong Sang-Bing; Hernández-Reséndiz Sauri; Crespo-Avilan Gustavo E; Mukhametshina Regina T; Kwek Xiu-Yi; Cabrera-Fuentes Hector A; Hausenloy Derek J (2018)

186 73-87

Mitochondria in acute myocardial infarction and cardioprotection.

EBioMedicine – Ramachandra Chrishan J A; Hernandez-Resendiz Sauri; Crespo-Avilan Gustavo E; Lin Ying-Hsi; Hausenloy Derek J (2020)

57

Mitochondrial-Shaping Proteins in Cardiac Health and Disease - the Long and the Short of It!

Cardiovascular drugs and therapy – Ong Sang-Bing; Kalkhoran Siavash Beikoghli; Hernández-Reséndiz Sauri; Samangouei Parisa; Ong Sang-Ging; Hausenloy Derek John (2017)

31 (1); 87-107

Responses of Endothelial Cells Towards Ischemic Conditioning Following Acute Myocardial Infarction.

Conditioning medicine – Hernández-Reséndiz Sauri; Muñoz-Vega Mónica; Contreras Whendy E; Crespo-Avilan Gustavo E; Rodriguez-Montesinos Julian; Arias-Carrión Oscar; Pérez-Méndez Oscar; Boisvert William A; Preissner Klaus T; Cabrera-Fuentes Hector A (2018)

1 (5); 247-258